Study: Quercetin in pollen allergies

reference

yamada s, Shirai M, Inaba Y, Takara T. Effects of repeated oral intake of a quercetin-containing nutritional supplement on allergic reactions: a randomized, placebo-controlled, double-blind parallel group study. EUR REV Med Pharmacol Sci . 2022: 26 (12): 4331-4345.

design

randomized, placebo -controlled double -blind study

Key to take away

The phytosome quercetin reduced several important pollinosis symptoms during the pollen season in these inhabitants Tokios over a period of four weeks.

participant

The study included 66 subjects (at the age of 22–78) with allergic symptoms of pollinosis during a pollen season in Tokyo, Japan. Ninety adults agreed to participate in the study and 66 qualified and were included in the study. Three subjects were later excluded and another three left the study. Ultimately, 60 subjects were included in the analysis. There were 18 women and 12 men in the treatment arm, 15 women and 15 men in the placeboot. The authors state that there were no significant differences at the beginning of the course; However, the high-density lipoprotein (HDL) in the placebo group was lower compared to the treatment group ( p = 0.02).

inclusion criteria: This included those with a relatively high score in the Japanese questionnaire of the quality of life in rhinoconjunctivitis (JRQLQ).

exclusion criteria: were excluded patients with previous cancer, heart failure, myocardial infarction; Heart pacemaker or defibrillator; Treatment of cardiac arrhythmias, liver dysfunction, kidney dysfunction, cerebrovascular disorders, rheumatoid arthritis, diabetes, dyslipidemia, high blood pressure and other chronic diseases; Taking functional food or drinks; Continuous taking medication against allergic eye and nose symptoms; Use of herbs or nutritional supplements; allergic to quercetin and lecithin; unable to follow instructions; Travel planning during the course of study; Practice of nasal gurgling (nasal rinsing); Pregnant, breastfeeding or planning to become pregnant during the study period; have participated in a clinical study in the past 3 months or are planned to take part in another clinical study during the study period; and considered unsuitable by the main investigator for this process.

study parameters

The researchers assessed the JRQL questionnaire, height, weight, body mass index (BMI), body fat, blood pressure, heart frequency, large blood count (CBC), aspartateotamine outransferase (branch), alanintran saminase (old) and gamma glutayayl transferase (GGT), lipid panel, glucose, Hemoglobular A 1C (HBA 1C ), complete urine analysis (UA), virological and immunoserological tests on hepatitis C, Humanes Immundeficiency Virus (HIV) and Treponema Pallida for . The primary end point was the JRQLQ score and secondary endpoints were allergic symptoms, nose outflow and a self-created questionnaire.

intervention

The researchers called the intervention a food because the quercetin was available in the phytosome form with Lecithin, available from Indena Spa, Milan, Italy. The studio dose was 50 mg quercetin per tablet, 2 tablets twice a day for breakfast and dinner. The placebo contained the same amount of vehicles per tablet, also two tablets twice a day, for breakfast and dinner. The researchers found that it was impossible to distinguish between the test and placebo food based on the taste or the external appearance.

primary result

Changes in the JRQLQ scores

most important knowledge

The JRQLQ-VestamtCores were lower in the treatment arm after 4 weeks in the overall score ( p = 0.04), total number of quality of life ( p = 0.02) and sleep and physical values ​​( p = 0.00). In the detailed breakdown of the JRQLQ scores after 4 weeks compared to the starting value, the treatment low in the sneezing was significantly better ( p = 0.04), mental focus ( p = 0.01), ability to participate in outdoor activities ( p = 0.01), improved sleep ( p = 0.01), reduction of fatigue ( p = 0.02); and facial swelling ( p = 0.03).

transparency

The authors stated that there are no conflicts of interest. Financing of the study according to the authors: "This study was carried out on behalf of Indena Japan Co., Ltd. and Indena Spa at the expense of the clients." Indena Spa is the manufacturer of the quercetin phytosome.

effects on practice

rhinitis is an allergic reaction of type 1 that is associated with the degranulation of mast cells due to an excessive immunoglobulin e (ige) reaction to the allergen, histamine release, mucus release, eye conjunctionitis, hives and eczema, asthma and even anaphylaxis. Incidence of anaphylaxis in the population can be up to 2 %, increases in younger population groups and can be up to 20 % to 30 % in North America. ^{2 In Tokyo, the main causes of Japanese cedar, Cryptomeria japonica pollen are (48.8 % of the population), other allergens, other allergens, other allergens) Air pollution and infections.}

quercetin, a bioflavonoid with extensive research, has an effect by inhibiting mast cell activation, reduction in histamine release and the resulting inflammation by eosinophil activation, inhibition of lipopolysaccharide-induced tumor necrosis alpha (TNF-α) and inhibition of lipid peroxidation, Blood platelet aggregation and capillary perpetration are one of its diverse effects. The stimulation of mitochondrial biogenesis. ^{3 In 1957 it was identified using oaks ( quercus ) and is yellow. Oral bioavailability is only 2 to 17 %. 3 vitamin C, folic acid and the simultaneous use of other flavonoids can increase the absorption rates. Half -life studies show an range of 3.5 to 28 hours, whereby the excretion is mainly via the kidneys.}

vitamin C, folic acid and the simultaneous use of other flavonoids can increase the absorption rates.

The phytosome formulation was querycetin of sophora japonica and sunflower lecithin in a ratio of 1: 1, standardized on 40 % quercetin. 5 in a single -dose attempt on healthy adults aged 18 to 50 years, based on 12 blood samples from the starting value to 24 hours after taking and 3 cans of either 500 mg Quercetin, 250 mg quercetin phytosome or 500 mg quercetin phytosome, the area was 4,774.9 ng/ml, 50.401.5 ng/ml or 96,163.8 ng/ml, which is a 105-fold increase between 500 mg quercetin and 500 mg quercetin-phytosome corresponds.

In a three-month study on the prevention of Covid-19 for 120 health care staff (60 placebo, 60 treatment), which used 250 mg quercetin phytosome twice a day, there were fewer covid-19 and faster recovery. After 5 months, the COVID-Free survival was 99.8 % in the treatment group compared to 96.5 % in the control group, which is a 14 % higher protection factor for non-inserting with a SARS-COV-2 infection. Employees in the healthcare sector showed that 1 employees in the treatment group on Covid-19, while 9 out of 42 (21.4 %) in the control group on Covid-19 affected group has become infected with the SARS-COV-2 infection. ^{7 In these experiments, immune cinema is probably one of the possible mechanisms. Aging cells.}

My clinical experience with quercetin usually includes 500 mg quercetin with 500 mg vitamin C in a two or three daily prescription for allergies and early infections with good success, especially if treatment is started 7 to 14 days before the outbreak of local allergy. Pollen season, which confirms the above results. Since I had no access to the quercetin phytosome, I cannot say how it does in comparison, although it may seem more effective. The decisive factor for my use in patients will be the costs compared to the suspected greater benefit.