Study: Night fasting improves the breast cancer forecast
Study: Night fasting improves the breast cancer forecast
reference
Marinac Cr, Nelson Sh, Breen Ci, et al. Longy night fasting and breast Cancer forecast. Jama oncol . 2016; 2 (8): 1049-1055
objective
It should be examined whether the duration of the nightly fasting will recover and the mortality of women with breast cancer predicted in the early stages and, if so, whether this was associated with risk factors for poor results
design and participant
The researchers collected and analyzed data from 2,413 women with breast cancer who took part in the Women’s Healthy Eating and Living (Whhel) between March 1, 1995 and May 3, 2007. The women were between 27 and 70 (average age 52.5 years). ) in the diagnosis. None of the participants had diabetes mellitus. The average follow -up period of the study was 7.3 years; Breast cancer or mortality of any cause was followed for 11.4 years. The data analysis was carried out from May 18 to October 5, 2015.
medication and dosage study
The duration of the nightly fasting was estimated using 24-hour nutritional memories that were collected at the start of the course, year 1 and year 4 of the study.
target parameter
clinical results were the recurrence of invasive breast cancer and new primary tumors during the 7.3-year follow-up and death from breast cancer or any cause during the 11.4-year surveillance. The output sleep time was specified and archived blood samples were used to determine the concentrations of hemoglobin A 1C (HBA 1C ) and C reactive protein (CRP). The body mass index (BMI) was calculated based on data that was collected during the study.
important knowledge
women in this cohort fasted for an average (SD) duration of 12.5 (1.7) hours per night. Less than 13 hours of fasting per night (lower 2 tertile distribution at night) was associated with a 36%increase in breast cancer recurrence risk, compared to a fasting of 13 or more hours per night [Hazard Ratio (HR): 1.36; 95% Confidence Interval (CI): 1.05-1.76] In analysis by COX-Proportal-Hazards regression models (with repeated measurements). Nocturnal fasting for less than 13 hours was associated with a less than significant trend on a higher risk of breast cancer mortality (HR: 1.21; 95 %-KI: 0.91–1.60) and total mortality (HR: 1.22; 95 %-KI: 0.95–1.56)).
This seems to be the first study on humans who were looking for a direct connection between night fasting and the outcome of breast cancer.
In multivariables linear regression models, every extension of the nighttime fasting time was associated with a significantly lower HBA 1c (β = -0.37; 95 %-KI: -0.72 to -0.01) and a longer night sleep time (β = 0.20 %-KI: 0.14-0,26).
practice implications
As a practitioner of naturopathy, we always look for simple changes in the lifestyle that improve Health. In patients with breast cancer in history, strategies to improve health often focus on reducing the risk of relapse. This study suggests an elegantly simple intervention that could have a significant benefit: the extension of the period in which women do without food at night - Lent between dinner and breakfast. In this cohort of women in whom the average Lent was 12.5 hours, those who fasted less than 13 hours a night had a 36 % higher risk of recurring breast cancer.
This seems to be the first study on people who sought a direct connection between night fasting and the outcome of breast cancer. In animals, calorie restriction is an effective means of reducing the risk of cancer. 1 Interestingly, intermittent calorie restriction prevents the development of breast cancer just as well or even better than chronic calorie restriction. Has tumor progression in mice. Mice, the feeding times of which were limited, had smaller tumors than mice that were fed ad libitum. 3 strangely, the feeding of mice in light was also associated with less tumor growth.
In this group of women who were part of the well-known Whel-Studienkohlorte, long-term fasting was associated with a lower HBA 1C level, a result that resembled what was in 2010 by Giovanucci et al. It was reported that the data from the National Health and Nutrition Examination Survey (Nhanes) analyzed. 4 It may be that longer fasting reduces both blood sugar and insulin production, two measures that can restrict the growth of breast cancer cells. Erickson et al. in 2011 reported in another analysis of data from the Whel cohort that women with a HBA 1C > 7.0 % had an HR for the overall mortality of 2.35 (95 % AI: 1.56–3.54) compared to women with a HBA
In an analysis of Nhanes data in August 2015, Marinac et al.
In this current work, longer fasting was not correlated with the BMI. Longer fasting was associated with a long sleeping time. Late food disturbs the circadian rhythm. The numerous studies by Eva Schernhammer with night shift workers have provided convincing evidence that a circadian misalignment is associated with an increased risk of cancer, including increased breast cancer risk.
Although these results are the result of a retrospective analysis of data that was collected two decades ago, the results are fascinating. There are those who will suggest that we are waiting for more definitive data from a prospective randomized study before we bring this practice into clinical use. I am not part of this group because there is currently no evidence that longer fasting at night is associated with increased risk. In the worst case, it can prove to be ineffective. Since this study indicates an almost 40%postponement of the cancer relapse rates, longer fasting can have a considerable value.
The obvious question that we do not know and will not know is whether the connection revealed by this data is causal or not. It could be that women who produce more insulin do without long nightly fasting because they become more hypoglycemic. It could turn out that this eating behavior serves as a biomarker than an intervention.
On our already simple recipes for daily movement, a healthy Mediterranean diet and sufficient sleep, we should add this recommendation for our breast cancer patients: "Eat dinner early and have breakfast late." It sounds almost too simple.
- Parisa MW. Calorial restriction, feeding at will and cancer. Proc Soc Exp. Biol. Med . 1986; 183 (3): 293-298.
- rogozina op, nkhata KJ, Nagle EJ, Grande JP, Cleary Mp. The protective effect of an intermittent calorie restriction on the development of mammatumors is not affected by consuming a high -fat diet while the food intake is resumed. breast cancer treatment . 2013; 138 (2): 395-406.
- Wu MW, Li XM, Xian LJ, Lévi F. Effects of food stiming on tumor progression in mice. life science . 2004; 75 (10): 1181-1193.
- Giovannucci e, Harlan DM, Archer Mc, et al. Diabetes and cancer: a consensus report. diabetes treatment . 2010; 33 (7): 1674-1685.
- Erickson K., Patterson Re, Flatt SW, et al. Clinically defined diabetes mellitus type 2 and forecast for breast cancer in early stages. j clin oncol . 2011; 29 (1): 54-60.
- Marinac Cr, Sears DD, Natarajan L., Gallo Lc, Breen Ci, Patterson Re. The frequency and the circadian at the time of the food can affect biomarkers for inflammation and insulin resistance that are associated with the risk of breast cancer. plus one . 2015; 10 (8): E0136240.
- Schernhammer it, shop f, Speizer Fe, et al. Rotating night shifts and breast cancer risk in women who took part in the health study of the nurses. J National Cancer Inst . 2001; 93 (20): 1563-1568.
Kommentare (0)