Study: green tea consumption and breast cancer risk

Study: green tea consumption and breast cancer risk
In the present study, it was examined whether the consumption of green tea influences the risk of breast cancer in Japanese women. It is a prospective study in which a total of 53,793 women were accompanied over a period of 13.6 years. The study showed that the consumption of green tea showed no statistically significant difference in the risk of breast cancer, regardless of whether the women drank more than 5 to 10 cups a day or less than one cup a day. The results contradict earlier studies that show a reduction in breast cancer risk in women who consumed a lot of green tea. However, it was pointed out that the effect can vary in various population groups and that further examinations are required.
Reference
iwasaki m, inoue m, sasazuki s, et al. Drinking green tea and the resulting breast cancer risk in a population -related cohort of Japanese women. breast cancer res. 2010; 12 (5): R88.
Design
This is a prospective study that accompanied 53,793 women in Japan. In this group of women, 581 cases of breast cancer were newly diagnosed within the first 5 years. After the first 5-year follow-up examination from 1995 to 1998, 350 further cases were newly diagnosed in 43,639 women during the 9.5-year follow-up examination. With the help of questionnaires that were carried out at the beginning of the course, the frequency of the entire consumption of green tea was determined. In the case of follow-up examinations after 5 years, the frequency of the consumption of sencha and bancha/genmaicha green tea was assessed and associated with breast cancer incidence over a period of 13.6 years.
most important knowledge
This prospective study showed no statistically significant difference in the frequency of breast cancer in women who consumed more than 5 to 10 cups of green tea (1 cup of tea = 4 ounces tea) per day, compared to women, which over a period of less than one cup per day consumed average afternoon period of 13.6 years. Compared to women who drank less than 1 cup of green tea a week, the adapted hazard ratio (HR) was 1.12 (95 %confidence interval) for women who drank 5 or more cups a day). [CI] 0.81–1.56; P for trend = 0.60) in the basic data. Compared to women who drank less than 1 cup of Sencha or Bancha/Genmaicha per week, the adapted HRS for women who drank 10 or more cups per day were 1.02 (95 %KI 0.55–1.89; p for trend = 0.48). and 0.86 (0.34–2.17; p for trend = 0.66) for Bancha/Genmaicha. Neither the hormone receptor status of breast cancer nor the menopause status influenced these results.
effects on practice
This large -scale, population -based prospective cohort study in Japan, together with two other Japanese cohort studies, 1,2 refuted the results of several prospective studies, which had previously shown a statistically significant reduction in breast cancer risk in women, the large amounts of green tea Consumed.
Even if the results of this study contradict some previous studies, there are several reasons to seriously consider this latest study. The study was prospectively designed, a strong study design. The study had the advantage that there were big differences in regular consumption of green tea - from less than 1 cup of up to more than 10 cups a day. About 12 % of women drank less than 1 cup of green tea per week in the basic data and 27 % drank 5 or more cups a day. In the 5-year follow-up data, 22 % or 30 % of women did not drank a Sencha and Bancha/Genmaicha, while 5.2 % or 2.5 % 10 or more cups per day drank. The response rate of over 80 % on the questionnaire underpinned the statistical analysis. While the self -disclosure via a questionnaire may have led to inaccurate results, the validity of the questionnaire was confirmed by a validation study. 6 In addition, these researchers previously used the same study design and the methodology and made a connection between the consumption of green tea and a lower risk for distal gastric cancer and advanced Prostate cancer. This would indicate reliable methodology. No drinking methods were controlled in the study that could possibly have had an impact on the overall availability of polyphenol. However, the researchers led a nested case control study through
It is important to recognize that other cohort studies have shown a statistically significant benefit in other population groups - especially in Chinese women who have started consuming green tea before the age of 25 and in which the risk of breast cancer is lower before menopause. In addition, Japanese women who live in the United States and who have already been diagnosed with breast cancer in the early stages and who have received final treatment, benefit from the consumption of at least 8 cups of green tea per day and thus increase their chance to survive. In a group of women who already have a relatively low risk of developing breast cancer, the frequent consumption of green tea is not an effective prevention strategy. The lack of benefits in this study could also be due to the fact that the entire polyphenol consumption of food in Japanese standard diet is quite high. This can cover up the effect of the polyphenols from green tea, even if it is consumed in relatively large quantities.
It is possible that the polyphenol from consuming green tea in women who have a diet with a low polyphenol content, such as the typical western diet, could have a greater preventive effect.
It is possible that the polyphenols from the consumption of green tea in women who have a diet with a low polyphenol content, such as the typical western diet, could have a greater preventive effect. In addition, women with a higher risk of having breast cancer in history, women with genetic polymorphisms who influence polyphenol or folk metabolism, and possibly also younger women benefit from the cancer-preventing effect of green tea.
restrictions
The relatively low incidence of breast cancer in Japanese women (the age -standardized rate per 100,000 in 2002 was 32.7 in Japan compared to 101.1 in the United States) may require a larger but significant effects. Although this study controlled a number of potentially confusing variables, other, non -identified factors could also have falsified the results.
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