Study: nutrition for prostate cancer survivors
![Referenz Wilson KM, Mucci LA, Drake BF, et al. Verzehr von Fleisch, Fisch, Geflügel und Eiern bei Diagnose und Risiko des Fortschreitens von Prostatakrebs. Krebs Prev Res (Phila). 2016;9(12):933-941. Studienziel Es sollte der Zusammenhang zwischen dem Wiederauftreten von Prostatakrebs und dem Verzehr von rotem Fleisch, verarbeitetem und unverarbeitetem rotem Fleisch, Geflügel, Fisch und Eiern insgesamt untersucht werden Teilnehmer Die Studie umfasste 971 Männer, die wegen Prostatakrebs und der Erkrankung im klinischen Stadium T1 (81 %) oder T2 (19 %) mit radikaler Prostatektomie behandelt wurden (mittleres prostataspezifisches Antigen [PSA]=5,9 ng/ml); Männer nahmen an der Washington University Genetics Study teil, einer Kohorte …](https://natur.wiki/cache/images/SIBO-and-Anti-Inflammatories-Boswellia-Curcumin-jpg-webp-1100.webp)
Study: nutrition for prostate cancer survivors
Reference
Wilson KM, MUCCI LA, Drake Bf, et al. Consumption of meat, fish, poultry and eggs at diagnosis and risk of progression of prostate cancer. Krebs Prev Res (Phila) . 2016; 9 (12): 933-941.
Study goal
The connection between the recurrence of prostate cancer and the consumption of red meat, processed and unprocessed red meat, poultry, fish and eggs as a whole should be examined
participant
The study included 971 men who were treated with radical prostate -specific antigen [PSA] = 5.9 ng/ml) because of prostate cancer and the clinical stage T1 (81 %) or T2 (19 %); Men took part in the Washington University Genetics Study, a cohort of men with prostate cancer diagnosed by biopsy, which were treated in St. Louis between 2003 and 2010.
target parameter
Details of diagnosis, initial treatment and follow -up examinations were collected from medical records. After diagnosis and before treatment, the men filled a questionnaire with demographic information, smoking and health information as well as a questionnaire for the frequency of food (FFQ). The logistical regression was used to examine the connection between nutrition and high -grade or advanced illness for all 971 participants. Only participants with the pathological stage T3N0M0 (n = 940) were included in the recurrence analysis cohort. The median post -observation period was 3.0 years (area: 1 month to 7 years, 8 months).
medication and dosage study
The FFQ evaluated the frequency of consumption of 137 individual foods, 77 with questions about the usual portion size and fraud, in the year before the diagnosis. Additional questions about preparation methods, including the frequency of eating fried food and preferences for the cooking degree of meat.
important knowledge
The consumption of fried and fried red meat was associated with an advanced disease at the time of the diagnosis (odds ratio [or] upper vs. lower quartile: 1.74; 95% confidence interval [CI]: 1.05-2.90; p for trend = 0.01). Less cooked meat and the general meat intake were not associated with advanced disease. There was no connection with other nutritional parameters.
The total absorption of red meat was associated with high grade (Gleason 4+3) prostate cancer (hazard ratio [HR]: 1.66; KI: 0.93-2.97; p for trend = 0.05) at the time of the diagnosis. At the time of the diagnosis, no other nutritional parameters were associated with high -grade prostate cancer.
of the 940 men in the pathological stage T3N0M0 or lower had a recurrence of prostate cancer (10 %), which due to an increasing PSA value (n = 79), the beginning of a new treatment (n = 12) or signs of metastases (n = 3). When comparing quintile, the consumption of red meat, fish, poultry or eggs was not associated with a new occurrence.
Using a substitution model, the authors calculated that the replacement of 30 grams of red meat per day would lead to a significantly lower risk of recurrence through 30 grams of poultry or fish (HR: 0.79; 95 %KI: 0.66–0.94). This calculation applied to unprocessed red meat (HR: 0.76; 95 % AI: 0.63–0.92), but not for processed red meat (HR: 1.05; 95 % AI: 0.67–1.64). No other nutritional categories or substitutions achieved a statistical significance when comparing the upper quartile of consumption with the lower quartile.
Neither the overall absorption of red meat nor eggs was significantly associated with the risk of illness.
practice implications
While we are excited about all data that men can inform men with prostate cancer about which lifestyle decisions slow down the progression of their illness, this study contributes little to our knowledge basis.
The authors explain: "Our results speak for men with prostate cancer, replace red meat and eggs in diet with poultry or fish. This is associated with a reduced risk of recurrence regardless of the stage and severity when diagnosing and is in accordance with earlier findings on nutrition and prostate-crift survival rate."
The authors of this study imply associations between food components and disease risk, but these associations did not achieve statistical significance. They entered several almost plausible word elections to make these implications, such as the following:
- "We have found a positive association with a progression after radical prostatectomy for eating eggs."
- "Total absorption of red meat was a marginal connected with the risk of a high degree of illness."
- "We have seen a proposal of a positive association for fried poultry and reverse association for non -fried poultry and repetition."
- "This study opens up the possibility that the replacement of red meat and eggs by poultry or fish could slow the progression in men who were treated in surgically due to prostate cancer."
suggestive associations, marginal associations, possibilities and other twists do not correspond to a statistically significant association.
The authors also resorted to creative comparisons. In an attempt to find a high absorption of eggs in connection with diseases, they compared the top Decil consumption against the soil quartile and were able to report an OR of 1.98 with an 95 % AI from 1.08 to 3.63, and a p value for trend of 0.08. Note the p value for the trend is larger than 0.05. Similar statistical manipulation was used to imply that a very high poultry consumption was associated with a progression (hr top decil vs. lower quartile: 0.19; 95 % KI: 0.06–0.63; p for trend = 0.02).
suggestive associations, marginal associations, possibilities and other twists do not correspond to a statistically significant association.
Comparisons are usually not carried out in these studies. Equivalent segments of a data record should be used for comparison; For example upper quartile vs. lower quartile. All of these examples describe trends that have not achieved statistical significance and should have been reported as "no association" or "no significant association".
While advocates of precise reporting prefer that authors only report results that are statistically significant, there may be more generous readers who would like to be informed about strong trends that bounds of statistical significance. Nevertheless, you expect the choice of language to make it clear that such trends were not significant.
This inaccurate spelling confuses the average reader. The study closes with information that we already suspected:
"In summary, our results support the advice for men with prostate cancer, red meat and eggs in diet with poultry or fish. This is associated with a lower risk of recurrence regardless of stage and severity in diagnosis and is in accordance with earlier knowledge of nutrition and survival of Prostate cancer. “
What should we men with prostate cancer now say about nutrition and lifestyle?
The most informative study so far is the study by Kenfield et al. from 2015 via the lifestyle score. On the basis of data from the Health Professionals Follow-Up Study (HPFS; N = 42.701), Kenfield and colleagues developed a "lifestyle score" to classify characteristics that influence prostate cancer. They addressed this evaluation method for the HPFS cohort and the 20,324 men in the Physicians' Health Study (PHS). One point was awarded for each of these properties:
- currently not smoking or stopped 10 or more years ago
- Body-Mass index below 30 kg/m
2 - High strong activity
- high intake of tomatoes and fat fish
- low intake of processed meat
- don't smoke.
- keep a BMI below 30 kg/m
2 . - train vigorously.
- eat a lot of tomatoes and fat fish.
- limit the consumption of processed meat.
- Avoid fried and fried meat.
- replace red meat in diet with poultry or fish.
- avoid poultry skin and eggs.
- replace some carbohydrates and animal fat with vegetable fat.
men with 5 to 6 vs. 0 to 1 points had a 68 % reduced risk of fatal prostate cancer (HR: 0.32; KI: 0.19–0.52) in the HPFS and a not significantly reduced risk (HR: 0.62; 95 % CI: 0.30-1.26) in the pH. Only for nutritional factors had men with 3 vs. 0 points a 46 % reduced risk (HR: 0.54; 95 %-KI: 0.30–0.96) in the HPFS and a not significantly reduced risk (HR: 0.70; 95 % KI: 0.40). -1.23) in the phs.
Based on the Kenfield study, the current study, a study by Richman from 2010, 2 and a study by 2013 by Kenfield and Richman together,
- Kenfield SA, Batista JL, Jahn JL, et al. Development and application of a lifestyle scor for the prevention of fatal prostate cancer. J National Cancer Inst . 2015; 108 (3). PII: DJV329.
- Richman el, stamper MJ, Pacierek A, Broering JM, Carroll PR, Chan JM. Acceptance of meat, fish, poultry and eggs and risk of progression of prostate cancer. am j clin nutr . 2010; 91 (3): 712-721.
- Richman El, Kenfield SA, Chavarro Je, et al. Fating after the diagnosis and risk of fatal prostate cancer and overall mortality. Jama internal med . 2013; 173 (14): 1318-1326.
Kommentare (0)