Study: nutrition for prostate cancer survivors

Reference

Wilson KM, MUCCI LA, Drake Bf, et al. Consumption of meat, fish, poultry and eggs at diagnosis and risk of progression of prostate cancer. Krebs Prev Res (Phila) . 2016; 9 (12): 933-941.

Study goal

The connection between the recurrence of prostate cancer and the consumption of red meat, processed and unprocessed red meat, poultry, fish and eggs as a whole should be examined

participant

The study included 971 men who were treated with radical prostate -specific antigen [PSA] = 5.9 ng/ml) because of prostate cancer and the clinical stage T1 (81 %) or T2 (19 %); Men took part in the Washington University Genetics Study, a cohort of men with prostate cancer diagnosed by biopsy, which were treated in St. Louis between 2003 and 2010.

target parameter

Details of diagnosis, initial treatment and follow -up examinations were collected from medical records. After diagnosis and before treatment, the men filled a questionnaire with demographic information, smoking and health information as well as a questionnaire for the frequency of food (FFQ). The logistical regression was used to examine the connection between nutrition and high -grade or advanced illness for all 971 participants. Only participants with the pathological stage T3N0M0 (n = 940) were included in the recurrence analysis cohort. The median post -observation period was 3.0 years (area: 1 month to 7 years, 8 months).

medication and dosage study

The FFQ evaluated the frequency of consumption of 137 individual foods, 77 with questions about the usual portion size and fraud, in the year before the diagnosis. Additional questions about preparation methods, including the frequency of eating fried food and preferences for the cooking degree of meat.

important knowledge

The consumption of fried and fried red meat was associated with an advanced disease at the time of the diagnosis (odds ratio [or] upper vs. lower quartile: 1.74; 95% confidence interval [CI]: 1.05-2.90; p for trend = 0.01). Less cooked meat and the general meat intake were not associated with advanced disease. There was no connection with other nutritional parameters.

The total absorption of red meat was associated with high grade (Gleason 4+3) prostate cancer (hazard ratio [HR]: 1.66; KI: 0.93-2.97; p for trend = 0.05) at the time of the diagnosis. At the time of the diagnosis, no other nutritional parameters were associated with high -grade prostate cancer.

of the 940 men in the pathological stage T3N0M0 or lower had a recurrence of prostate cancer (10 %), which due to an increasing PSA value (n = 79), the beginning of a new treatment (n = 12) or signs of metastases (n = 3). When comparing quintile, the consumption of red meat, fish, poultry or eggs was not associated with a new occurrence.

Using a substitution model, the authors calculated that the replacement of 30 grams of red meat per day would lead to a significantly lower risk of recurrence through 30 grams of poultry or fish (HR: 0.79; 95 %KI: 0.66–0.94). This calculation applied to unprocessed red meat (HR: 0.76; 95 % AI: 0.63–0.92), but not for processed red meat (HR: 1.05; 95 % AI: 0.67–1.64). No other nutritional categories or substitutions achieved a statistical significance when comparing the upper quartile of consumption with the lower quartile.

Neither the overall absorption of red meat nor eggs was significantly associated with the risk of illness.

practice implications

While we are excited about all data that men can inform men with prostate cancer about which lifestyle decisions slow down the progression of their illness, this study contributes little to our knowledge basis.

The authors explain: "Our results speak for men with prostate cancer, replace red meat and eggs in diet with poultry or fish. This is associated with a reduced risk of recurrence regardless of the stage and severity when diagnosing and is in accordance with earlier findings on nutrition and prostate-crift survival rate."

The authors of this study imply associations between food components and disease risk, but these associations did not achieve statistical significance. They entered several almost plausible word elections to make these implications, such as the following:

• "We have found a positive association with a progression after radical prostatectomy for eating eggs."
• "Total absorption of red meat was a marginal connected with the risk of a high degree of illness."
• "We have seen a proposal of a positive association for fried poultry and reverse association for non -fried poultry and repetition."
• "This study opens up the possibility that the replacement of red meat and eggs by poultry or fish could slow the progression in men who were treated in surgically due to prostate cancer."