A new study shows that replica of 14-day embryo models from stem cells could revolutionize the view of early human development

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Eine neue wegweisende Studie hat das Potenzial, die Möglichkeiten der Erforschung der menschlichen post-Implantationsentwicklung zu revolutionieren. Bisher waren aufgrund ethischer und technischer Herausforderungen nur begrenzte Erkenntnisse über die Entwicklung nach der Einnistung in die Gebärmutter möglich. Es fehlten Modelle, die die räumlich organisierte Morphogenese aller definierten embryonalen und extraembryonalen Gewebe des post-Implantationskonzeptus des Menschen nachstellen konnten, wie der embryonale Diskus, der bilaminare Diskus, der Dottersack und der Chorionsack samt umgebenden Trophoblasten. All dies ändert sich nun dank der neuesten Forschungsergebnisse, die zeigten, dass naive embryonale Stammzellen von Mäusen embryonale und extraembryonale Stammzellen hervorbringen können. Diese Zellen waren in der Lage, …
A new pioneering study has the potential to revolutionize the possibilities of researching human post-implantation development. So far, due to ethical and technical challenges, limited knowledge about the development in the uterus was possible. There were no models that were able to reproduce the spatially organized morphogenesis of all defined embryonic and extraembryonal tissues of the man's post-implantal concept, such as the embryonic discus, the bilaminar disc, the yolk sack and the chorionack including surrounding trophoblasts. All of this is now changing thanks to the latest research results, which showed that naive embryonic stem cells from mice can produce embryonic and extra -embryonic stem cells. These cells were able to ... (Symbolbild/natur.wiki)

A new pioneering study has the potential to revolutionize the possibilities of researching human post-implantation development. So far, due to ethical and technical challenges, limited knowledge about the development in the uterus was possible. There were no models that were able to reproduce the spatially organized morphogenesis of all defined embryonic and extraembryonal tissue of the man's post-implantal concept, such as the embryonic discus, the bilaminar disc, the yolk sac and the chorionack and surrounding trophoblasts.

All of this is now changing thanks to the latest research results, which showed that naive embryonic stem cells of mice can produce embryonic and extraembryonal stem cells. These cells were able to form themselves to make themselves too morphogenetically structured embryonic models, known as the Structured Stem Cell-Based Embryo Models (SEMS), which were able to imitate the postgastrular condition.

These groundbreaking results have now been transferred to humans, and the special thing is that only genetically unchanged naive embryonic stem cells were used. These outstanding SEMS of humans represent the organization of almost all known lines and compartments post-implant stages of the human embryo, including the epiclast, the hypoblast, the extraemryonal mesoderm and the trophoblast that surrounds these tissue layers.

It is exciting that these fully integrated sems of humans also reflect growth and dynamics of development in post-implantation development up to 13-14 days after fertilization, i.e. the Carnegie stage 6a. This includes the formation of the embryonic discus and the bilaminar discus, the lumenogenesis of the epiblast, the polarized amnion formation, the asymmetrical division in anterior posterior direction, the specification of primordial germ cells, the polarized formation of the yield sac with visceral and parietal, the spread of the extraemryonal Mesoderms that defines the formation of a chorion cavity and a connecting stole, and finally a trophoblast with syncytium and lacuna formation.

Thanks to this SEM platform, it will now be possible to experimentally research inaccessible sections of early human post-implantation development. This opens up completely new possibilities in the field of naturopathy and gives us insights into the processes that were previously in the dark.

The study to which this article refers was published in the renowned journal "Nature". For further information and for deepening we recommend the original source:

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