Dissolve mediators & inflammation

Dissolve mediators & inflammation

Dissolve mediators & inflammation

By Gene Bruno, MS, MHS, RH(AHG)

Huntington College for Health Sciences

Inflammation are an important mechanism that is involved in many human diseases. Since longer inflammation for the host is harmful, higher organisms have developed protective mechanisms to ensure the dissolution of the inflammatory reaction to a limited and specific period and space. Once intended as a purely passive process of dilution of inflammation, the resolution is now regarded as a highly orchestrated process that is coordinated by a complex regulatory network of cells and mediators. 1

Dissolve mediators
Among the molecules that facilitate dissolution, the lipid mediators that have attracted the most attention are resolvins, protectins, and maresins, which are generated from omega-3 fatty acids. These endogenous anti-inflammatory anddissolving mediatorscounteract the effects of pro-inflammatory signaling systems and act as “brake signals” on the ongoing vicious circle that leads to unstoppable inflammation.

In fact, the same pro-inflammatory factors that initially trigger the inflammatory response also signal the termination of inflammation by stimulating the biosynthesis of pro-inflammatory mediators. Resolvins, Protectins and Maresins have been shown to reduce respiratory inflammation, skin inflammation, colitis, arthritis and post-operative pain. Studies have shown that these mediators increase over time during the inflammatory process.2-4

Dha
While all omega-3 fatty acids can contribute to the formation of resolvins, docosapentaenic acid (dpa), an intermediate in the biosynthesis of DHA from EPA, is a particularly effective forerunner of four different resolvins, namely RVT1 (2), RVT3 (3) and RVT4.5 Nevertheless dpa is not always in Omega-3 fatty acid products found. However, it can be found in some liver trans products.

References:

Professor Gene Bruno, MS, MHS, provost for Huntington College of Health Sciences, is a nutritionist, herbalist, author and educator. For more than 37 years, he has educated and trained natural products retailers and healthcare professionals, researched and formulated natural products for dozens of dietary supplement companies, and authored articles on nutrition, herbal medicine, nutraceuticals, and integrative health topics for trade and consumer magazines and peer-reviewed publications. He can be reached at gbruno@hchs.edu.

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