Trojanian horse nanoparticles kill cancer cells without medication

Trojanian horse nanoparticles kill cancer cells without medication

Efficient cancer treatment: Scientists develop groundbreaking “Trojan Horse” mechanism

Scientists looking for more efficient methods of cancer treatment recently achieved a remarkable breakthrough. They have developed a new mechanism to inhibit cancer nanoparticles in cancer cells. This mechanism is based on the principle of "Trojan horse" from ancient Greek mythology, in which the nanoparticles camouflage themselves as supposedly harmless amino acid and thus cause the cancer cells to destroy themselves.

This innovative method is nano-paam, a nanoparticle with a diameter of only 30 nanometers. These ultra-small particles are impregnated with a certain amino acid called L-Phenylalanine, which is crucial for the growth of cancer cells. The cancer cells unknowingly absorb these amino acid and let the nanoparticles penetrate their structure. This ultimately leads to the self -destruction of the cancer cells.

The effectiveness of nano-pawam was extensively tested in the laboratory. About 80 percent of breast, skin and stomach cancer cells were killed, a rate comparable to some of the currently used cancer medication. In addition, it was observed that tumor growth in mice, which humanly triple negative breast cancer cells were implanted, was reduced by about 60 percent.

Assistant Professor Dalton Tay from Nanyang Technological University Singapore (NTU Singapore), which was involved in the study, emphasizes the importance of this new approach: "Our approach was to use the nanomaterial as a medicine instead of as medicinal products. The amino acid L-Phenylalanin acts as a 'Trojan horse' that mask the nanotherapeutics inside.

This innovative approach offers promising opportunities for the treatment of cancer species that do not respond to conventional therapies such as chemotherapy. Cancer types that have developed resistance to the currently available medication could continue to be susceptible to the "Trojan horse" approach, since it has a different mechanism of action

The NTU Singapore researchers now have the goal of further optimizing the design of Nano-Ppaam in order to tailor it to certain types of cancer and to increase efficiency in combating tumors. Although further refinements and tests are necessary, the preliminary results show the considerable potential of this method to improve cancer treatment and give hope for those who fight with this disease.

progress such as this underlines the importance of continuous research and innovation. The innovative approach of the NTU Singapur could be a paradigm shift in cancer treatment and possibly initiate a new era more efficient, more targeted cancer therapies.

sources:
- Nanyang Technological University Singapore (NTU Singapore): "Trojan Horse" Nanomedicine Could Destroy Cancer Cells Without Using Drugs
- IFL Science: "Trojan Horse" Nanoparticles Can Kill Cancer Cells