Vitamin D and calcium can reduce the risk of early menopause

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Von: Natur.wiki Autoren-Team

Bezug Purdue-Smithe AC, Whitcomb BW, Szegda KL, et al. Vitamin-D- und Kalziumaufnahme und Risiko einer frühen Menopause. AJCN. 2017;105(6):1493-1501. Entwurf Beobachtungsstudie basierend auf Daten der prospektiven Nurses‘ Health Study II; Informationen zur Kalzium- und Vitamin-D-Aufnahme wurden aus Fragebögen zur Häufigkeit von Nahrungsmitteln (FFQ) gesammelt, die in der Studie verwendet wurden. Studienpopulation und Bewertung Die Nurses‘ Health Study II umfasste 1989 (als die prospektive Studie begann) 116.430 Frauen im Alter von 25 bis 42 Jahren. Grundlegende Informationen zu Alter, Größe, ethnischer Zugehörigkeit, Menarchealter und Bildungsniveau von Mutter und Vater wurden 1989 gesammelt; Follow-up-Informationen wurden 1991, 1995, 1999, 2003, 2007 und 2011 …
Cover Purdue-Smithe AC, Whitcomb BW, Szegda Kl, et al. Vitamin D and calcium intake and risk of early menopause. AJCN. 2017; 105 (6): 1493-1501. Design observation study based on data from the prospective Nurses' Health Study II; Information on calcium and vitamin D recording was collected from questionnaires on the frequency of food (FFQ) that were used in the study. Study population and evaluation The Nurses' Health Study II comprised 116,430 women aged 25 to 42 in 1989 (when the prospective study began). Basic information on age, size, ethnic belonging, menarching age and level of education of mother and father were collected in 1989; Follow-up information was in 1991, 1995, 1999, 2003, 2007 and 2011 ... (Symbolbild/natur.wiki)

reference

Purdue-Smithe AC, Whitcomb BW, Szegda Kl, et al. vitamin D and calcium intake and risk of early menopause. ajcn . 2017; 105 (6): 1493-1501.

draft

Observatory Study based on data from the prospective Nurses' Health Study II; Information on calcium and vitamin D recording was collected from questionnaires on the frequency of food (FFQ) that were used in the study.

study population and evaluation

The Nurses' Health Study II included 116,430 women aged 25 to 42 in 1989 (when the prospective study began). Basic information on age, size, ethnic belonging, menarching age and level of education of mother and father were collected in 1989; Follow-up information was collected in 1991, 1995, 1999, 2003, 2007 and 2011 with a follow-up rate of ≥ 89 %. The FFQs evaluated the inclusion of 131 foods, drinks and nutritional supplements last year. Covariates such as BMI and physical activity were also identified in every follow -up examination.

women who were diagnosed with cancer before the first follow -up examination in 1991 were excluded (n = 391). After this and other exclusions were applied, 86,234 women remained in the study.

study parameters evaluated

Vitamin D recording, calcium intake and age at the beginning of menopause

important knowledge

After taking into account age, years of packing, BMI, parity, lifelong breastfeeding, age in menarche, physical activity, percentage of the overall calories from herbal protein, alcohol intake and calcium intake, women in the highest quintile of the food intake of vitamin D (median intake of 528 IE/D) had a 17 % lower risk for a prehistoric Menopause as women with the lowest recording (median intake of 148 IE/D) ( p = 0.03). There was also a 13 % lower risk of premature menopause in women who took most of the calcium out of food compared to women with the lowest calcium intake.

When a woman comes to menopause before the age of 45, there is an increased risk of osteoporosis, cardiovascular problems, cognitive decay and premature mortality.

Conversely, additional vitamin D was not associated with a reduced risk of early menopause, and additional calcium intake was positive with an early menopause.

women with the highest absorption of vitamin D and calcium were also younger and more physically active, had a lower BMI, drank less alcohol and smoked less frequently.

clinical implications

According to the Centers for Disease Control and Prevention, most women experience menopause between the ages of 45 and 55. 1 If a woman comes to menopause before the age of 45, there is an increased risk of osteoporosis, cardiovascular problems, cognitive decay and premature mortality. Today we know that genetic factors are the most important factors for the age of the start of menopause is that nutrition and lifestyle can also play a role.

This study deals especially with 2 important food nutrients - vitamin D and calcium. Both nutrients influence the female reproductive organs. For example, the ovaries are crammed with vitamin D receptors. A lack of vitamin D and calcium is associated with gynecological and reproductive diseases such as polycystic ovarian syndrome (PCOS) and endometriosis.

In this study, food vitamin D and food calcium were each associated with a lower risk of early menopause. This makes sense because both vitamin D and calcium influence the health of the ovaries. For example, vitamin D increases the messenger-RNA expression of the anti-müller hormone (AMH), a paracrine regulator of the ovarian follicle development. 8.9 An increase in AMH is connected to a reduction in the accelerated aging of the ovaries. And colleagues out that a one-time supplement with high-dose (50,000 IE) vitamin D3 led to an average increase of 12.9 ± 3.7 % of AMH the following week. 11 with regard to the lack of vitamin D supplementation on the early menopause in this present study of purdue-Smith et al. If the authors speculated that the number of women who took vitamin D preparations was too low to see a connection. Of the 86,234 women in the study, only 40 vitamin D preparations took over 600 IE per day.

The other relevant aspect of this study is that it was not possible to completely distinguish the effect of vitamin D from the effect of calcium. Food with high amounts of vitamin D also have high amounts of calcium, which makes it impossible to precisely adjust the effect of each nutrient without the other. Overall, it cannot be assumed that the effect of dietary vitamin D is on the premature ovarian failure regardless of calcium and vice

This is the first study known to us to deal especially with vitamin D and calcium in connection with the risk of early menopause. It builds on a solid collection of studies that associated these nutrients with improved fertility, 12.13 presumably due to the same underlying effect of an increase in AMH. Women with humiliated AMH have an increased risk of infertility and premature menopause. In view of the influence of vitamin D and calcium from food on the increase in the AMH increase, this study underlines the association of modifiable factors of lifestyle with premature aging of the ovaries. Reducing the risk of early menopause also lowers the risk of comorbidities such as cognitive decay, osteoporosis, cardiovascular problems and premature death.

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