Exercise for glucose control in diabetes and prediabetes

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Bezug Sjoros TJ, Heiskanen MA, Motiani KK, et al. Erhöhte insulinstimulierte Glukoseaufnahme in beiden Bein- und Armmuskeln nach Sprintintervallen und Training mittlerer Intensität bei Patienten mit Typ-2-Diabetes oder Prädiabetes [published online ahead of print March 13, 2017]. Scand J Med Sci Sports. 2017;1-11. Studienziel Es sollten die Auswirkungen von Sprint-Intervalltraining (SIT) und kontinuierlichem Training mittlerer Intensität (MICT) auf die Aufnahme von Glukose und Fettsäuren in periphere Muskeln der Arme und Beine bewertet werden, einschließlich der Auswirkungen auf die Insulinsensitivität in diesen Muskeln. Entwurf Randomisierte, kontrollierte Studie; Die Teilnehmer wurden nach dem Zufallsprinzip entweder SIT oder MICT unterzogen, um die Auswirkungen …
Relation Sjoros TJ, Heikanen MA, Motiani KK, et al. Increased insulin-stimulated glucose absorption in both leg and arm muscles after sprinting intervals and training of medium intensity in patients with type 2 diabetes or prediabetes [published online Ahead of Print March 13, 2017]. Scand J med sci sports. 2017; 1-11. The aim of the effects of sprint interval training (sit) and continuous training of medium intensity (MICT) on the absorption of glucose and fatty acids in peripheral muscles of the arms and legs, including the effects on insulin sensitivity in these muscles. Draft randomized, controlled study; According to the random, the participants were either subjected to SIT or MICT to the effects ... (Symbolbild/natur.wiki)

reference

Sjoros TJ, Heikanen MA, Motiani KK, et al. Increased insulin-stimulated glucose absorption in both leg and arm muscles after sprinting intervals and training of medium intensity in patients with type 2 diabetes or prediabetes [published online Ahead of Print March 13, 2017]. Scand J med sci sports . 2017; 1-11.

Study goal

The effects of sprint interval training (sit) and continuous training of medium intensity (MICT) on the absorption of glucose and fatty acids in peripheral muscles of the arms and legs should be assessed, including the effects on insulin sensitivity in these muscles.

draft

randomized, controlled study; The participants were subjected to either SIT or MICT in order to compare the effects of physical activity on glucose and insulin parameters.

participant

26 sedentary people aged 40 to 55 years with the diagnosis of diabetes mellitus type 2 or prediabetes. Based on the exclusion criteria, none of the participants smoked, used narcotics, had a chronic illness or a defect that disabled daily life, had a history of anorexia nervosa/bulimia or asthma, currently or earlier exercised or had a maximum oxygen consumption (VO 2spitze )> 40 ml/kg/min (Vo 2spitze positively correlated with physical fitness). The SIT group comprised 9 men and 4 women; The MICT group comprised 7 men and 6 women.

study parameters evaluated

Both SIT and MICT groups trained 6 sessions within 2 weeks under controlled laboratory conditions. The sprint interval training comprised 4 to 6 rounds with full cycling for 30 seconds, followed by a 4-minute recovery phase (either do nothing or very light cycling). The training started with 4 fights per session and was increased to a maximum of 6 after each second session.

These results indicate that regular movement can help reduce the glucose level in patients with limited glucose control in a relatively short time (2 weeks).

Each MICT session consisted of 40 to 60 minutes of cycling with an intensity of 60 % of the maximum VO 2 . The training started at 40 minutes per session and was increased by 10 minutes to a maximum of 60 minutes after each second session. Both training modes also included a 5-minute warm-up and cooling phase with low intensity before and after each session.

Before and after the study, a hyperinsulinemic euglycemic clamp study (participants received insulin and glucose infusions for measuring insulin sensitivity) and an oral glucose tolerance test (OGTT). Positron emission tomography (PET) analysis with marked tracers was used to measure the absorption of glucose and free fatty acids (FFA) in the thigh and arm muscles.

primary result measurements

The following parameters were measured before and after the training sessions: weight, body mass index (BMI), fat (%), fat-free mass, vo glycosylated hemoglobin (HBA 1C ), hemoglobin, hematocrit, sober-glucose, sober-fold 2-hour glucose, OGTT 2-hour insulin, glucose surface under the curve (AUC) in OGTT, insulin-aucle in Ogt.

important knowledge

Both SIT and MICT training units led to a 25%increase in the insulin-stimulated glucose intake throughout the body. There was a significantly increased insulin-stimulated glucose absorption in all thigh and upper arm muscles. Two weeks Sit or Mict led to dramatic 138 % ( p <0.001) and 93 % ( p <0.001) increases the glucose recording of the quadriceps femoris (QF).

In both groups, the fatty acid intake in the QF muscle was increased, but not in the leg flies or biceps and triceps brachii.

peak-vo 2 improved by 5% ( p = 0.013) in the SIT group, without significant improvement in the MICT group.

practice implications

This study shows that both sit and MICT can improve measures to check glucose control in patients with diabetes or prediabetes. Both interval and continuous training improved the overall insulin sensitivity and increased the glucose and FFA absorption in QF significantly; The glucose absorption was also increased in other muscles. These results indicate that regular exercise can help reduce the glucose level in patients with limited glucose control in a relatively short time (2 weeks). Regular training trains the muscles to react better to insulin, and promotes the absorption of glucose and fatty acids from the serum. 1 If we recommend our patients with prediabetes or type 2-diabetes mellitus, we can encourage them to either complete continuous or interval training, depending on the form that is more pleasant (or more pleasant) Is, and let them know that both can help control their control condition.

Although sober glucose does not deviate from the values ​​before and after the study, the HBA 1C was decreased in the analysis according to the study. The acceptance of the HBA 1C is probably related to a postprandial decrease in the glucose mirror, since it was shown that physical activity lowers the postprandial glucose level depending on the duration and intensity for up to 24 hours.

This study only included a very small number of participants and took into account no possible effects of the female menstrual cycle or hormone therapy in menopause, two important restrictions. Estrogen hormones can influence the insulin resistance of some women: Preimenstrual insulin resistance can occur, 4 and hormone replacement therapy for postmenopausal women can reduce insulin resistance. Incorporate.

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