Study: urban air pollution and insulin resistance, type 2 diabetes and obesity

Von Natur.wiki Autoren-Team

Bezug Alderete TL, Habre R, Toledo-Corral CM, et al. Longitudinale Assoziationen zwischen Luftverschmutzung und Insulinsensitivität, β-Zellfunktion und Adipositas bei Latino-Kindern in Los Angeles [published online ahead of print January 30, 2017]. Diabetes. Zielsetzung Bestätigung der epidemiologischen Erkenntnis, dass Luftschadstoffe mit einem höheren Risiko für Typ-2-Diabetes mellitus (T2DM) verbunden sind Entwurf Längsschnittversuch Teilnehmer 314 Latino-Jugendliche im Alter zwischen 8 und 15 Jahren in der Gegend von Los Angeles, die an der Luftstudie des Childhood Obesity Research Center teilgenommen haben; Alle Teilnehmer waren entweder übergewichtig oder fettleibig. Diese Kinder wurden zwischen 2001 und 2012 rekrutiert und durchschnittlich 3,4 Jahre lang beobachtet. Keiner …
Cover Alderete TL, Habre R, Toledo Corral CM, et al. Longitudinal Associations between air pollution and insulin sensitivity, β-cell function and obesity with Los Angeles in Los Angeles [Published Online Ahead of Print January 30, 2017]. Diabetes. Objective confirmation of epidemiological knowledge that air pollutants are associated with a higher risk of type 2 diabetes mellitus (T2DM) Design Longitudinal attempt participants 314 Latino youth between the ages of 8 and 15 in the area of ​​Los Angeles, who took part in the air study of the Childhood Research Center; All participants were either overweight or obese. These children were recruited between 2001 and 2012 and observed for an average of 3.4 years. None ... (Symbolbild/natur.wiki)

reference

Alderete TL, Habre R, Toledo Corral CM, et al. Longitudinal Associations between air pollution and insulin sensitivity, β-cell function and obesity with Los Angeles in Los Angeles [Published Online Ahead of Print January 30, 2017]. diabetes .

objective

Confirmation of epidemiological knowledge that air pollutants are associated with a higher risk of type 2 diabetes mellitus (T2DM)

draft

longitudinal attempt

participant

314 Latino youth between the ages of 8 and 15 in the Los Angeles area who took part in the air study of the Childhood Obesity Research Center; All participants were either overweight or obese. These children were recruited between 2001 and 2012 and observed for an average of 3.4 years. None of the people included in the study was diabetic (judged by an oral glucose tolerance test) or took medication that would influence the insulin or glucose tolerance.

study parameters evaluated

pollutant values ​​in the ambient air, including nitrogen monoxide, nitrogen dioxide (no 2 ) and fine dust of less than 2.5 microns (pm2.5) were estimated on the basis of data collected by surveillance stations in the Los Angeles area. Monthly average exposure values ​​were calculated from daily values ​​and based on the removal of the measurement stations (using a distance square weighting algorithm).

doctors have to start paying attention to the countless harmful effects of simple inhaling of air in all metropolitan areas.

Insulin sensitivity was assessed with an insulin-modified frequently carried out intravenous glucose tolerance test with 13 samples. The data from this test provided an evaluation for the full body insulin sensitivity (Si), the acute insulin reaction to glucose (Airg) and the evaluation of the beta zell function (disposition index [di])). The body mass index (BMI) was also measured during the entire study.

primary result measurements

one of the primary result measurements:

  • full body insulin sensitivity
  • acute insulin reaction to glucose
  • beta cell function
  • obesitas

important knowledge

Both PM2.5 and No 2 were associated with a statistically significant reduction in insulin sensitivity; No 2 was associated with a statistically significant decrease in beta -tale function. Both PM2.5 and No 2 were connected to a statistically significant increase in the BMI.

practice implications

lifestyle approaches to prevention and treatment of insulin resistance, metabolic syndrome and T2DM typically focus on nutrition and movement in order to reduce the number of calories absorbed and increase the number of calories burned. Nevertheless, a number of environmental pollutants were clearly associated with an increased risk for T2DM, including persistent organic pollutants and arsenic.

In the past ten years, articles have started to connect vehicle gases - the air pollution of the surroundings, which is generally increased in all urban areas around the world - with metabolic anomalies. In the past 7 years, several studies have shown that adults and adolescents who are exposed to higher concentrations of nitrogen monoxide, no, 2 , and PM2.5 had higher installments of T2DM. Three studies have shown that children and adults with increased exposure to vehicle gases had a higher calculated insulin resistance (using the homeostatic model evaluation of insulin resistance [HOMA-IR]). 1-3 Da Homa-I-I-IR results are not always confirmed by glucose tolerance tests.

This new study contributes to the evidence that urban air pollution is associated with insulin resistance, beta zell function and obesity. Doctors have to start paying attention to the countless harmful effects of simple inhaling of air in all metropolitan areas. Air purification devices for at home that push air through a series of filters to remove particles up to a size of 1 micron should be on the list of "must-havees" for all patients, right next to water filters, organic variants of the "dirty dozen" (most toxic fruits and vegetables) and movement.

  1. chen Z, Salam Mt, Toledo Corral C, et al. Pollutants in the ambient air have adverse effects on the insulin and glucose high-homoostasis in Mexican Americans. diabetes treatment . 2016; 39 (4): 547-54.
  2. Toledo Corral CM R, Berhane K, et al. Effects of exposure to air pollution on the glucose metabolism in Los Angeles minority alike on this work. Pediatr Obes . 2016. DOI: 10.1111/IJPO.12188. [Epub Ahead of Print]
  3. Thiering E., Cyrys J., Kratzsch J. et al. Long-term pollution from traffic-related air pollution and insulin resistance in children: results of the Giniplus and Lisaplus birthday cohorts. Diabetology 2013; 56 (8): 1696-1704.