Study: probiotic treatment of sensitive skin

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Referenz Gueniche A, Philippe D, Bastien P, et al. Randomisierte, doppelblinde, placebokontrollierte Studie zur Wirkung von Lactobacillus paracasei NCC 2461 zur Hautreaktivität. Nutzen Sie Mikroben. 2014;5(2):137-145. Design Es handelte sich um eine randomisierte, doppelblinde, placebokontrollierte Studie. Die Hälfte der Teilnehmer erhielt einen Beutel mit Pulver Lactobacillus paracasei, 1×10^10 KBE. Die andere Gruppe erhielt ein Placebo-Beutel mit dem Lebensmittelzusatzstoff Maltodextrin. Die Studiendauer betrug 2 Monate. Teilnehmer An der Studie nahmen 64 kaukasische Frauen im Alter von 18 bis 40 Jahren teil, die anhand zweier Kriterien aufgrund ihrer empfindlichen Haut ausgewählt wurden: einem validierten Fragebogen und einer positiven Reaktion auf Capsaicin in …
Reference Gueniche A, Philippe D, Bastien P, et al. Randomized, double -blind, placebo -controlled study on the effect of Lactobacillus Paracasei NCC 2461 on skin reactivity. Use microbes. 2014; 5 (2): 137-145. Design it was a randomized, double -blind, placebo -controlled study. Half of the participants received a bag with powder lactobacillus paracasei, 1 × 10^10 kbe. The other group received a placebo bag with the food additive Maltodextrin. The duration of studies was 2 months. Participants in the study took part in 64 Caucasian women between the ages of 18 and 40, who were selected based on two criteria based on their sensitive skin: a validated questionnaire and a positive reaction to capsaicin in ... (Symbolbild/natur.wiki)

Reference

GUENICHE A, Philippe D, Bastien P, et al. Randomized, double -blind, placebo -controlled study on the effect of lactobacillus paracasei NCC 2461 on skin reactivity. use microbes . 2014; 5 (2): 137-145.

Design

It was a randomized, double -blind, placebo -controlled study. Half of the participants received a bag with powder lactobacillus paracasei , 1 × 10^10 kbe. The other group received a placebo bag with the food additive Maltodextrin. The duration of studies was 2 months.

participant

64 Caucasian women aged 18 to 40, which were selected based on two criteria based on their sensitive skin: a validated questionnaire and a positive reaction to capsaicin in low concentration.

study parameters

The capsaicin-inhalation test, the trans-epidermal water loss, clinical scores, self-assessment, marker of skin moisture (e.g. sodium lactate and urea), microbiological stool analysis, interleukin (IL) -10, IL-12 and transforming growth factor were assessed (TGF-Beta).

primary result dimensions

The effects of lactobacillus paracase i for sensitivity to skin and to restore the skin barrier function were the primary endpoints.

most important knowledge

General trends were shown lactobacillus paracasei positively on the skin sensitivity, the restoration of the skin barrier function and important physiological parameters. The intervention group had higher concentrations of lactobacillus at the end of the study (day 57). There was a statistically significant improvement in the perceived skin convenience in the intervention group compared to the placebo group ( p = 0.006).

effects on practice

skin reactivity is not a common term in the dermatological technical language in the United States. In Europe it is used to describe patients with "sensitive skin" who call US doctors. People with sensitive skin report symptoms such as heat, burning, stinging or itching if they are exposed to physical (heat, cold, wind) or chemical (external product use).
sensitive skin is also characterized by an impaired restoration of the skin barrier function. A barrier disorder leads to an increased penetration of irritating substances and a transverse water loss (TEWL). 2
sensitive skin often occurs in diseases such as neurodermatitis, contact dermatitis, psoriasis, rosacea and urticaria. Therefore, every intervention that could reduce the sensitivity of the skin in people with these diseases would be welcome. The use of a certain probiotic trunk is a new approach to relieving sensitive skin. This study builds on earlier examinations that were carried out by two of the authors (Gueniche and Philippe) at their respective positions in the research laboratories of L’Oréal in France and Nestlé in Switzerland. They worked on this study, which was carried out on the laboratoryatoire Dermscan in Lyon, France.
This had shown earlier studies lactobacillus paracasei ncc 2461 (ST11) modulates the immunehomöostasis and regulates immune -related disorders. 3 GUENIE had shown that a medium conditioned by substance p had been caused by substance, ingema Degranulation of mast cells and the release of tumor necrosis factors significantly reduced and also promoted the restoration and maintenance of the skin barrier function. 4 Philippe had confirmed this finding in vivo .
The present study showed that in the course of participants who were administered, a slight but significant decrease in skin sensitivity occurred to capsaicin over the course of the treatment period. The restoration of the barrier function, measured as a reduced TEWL, was much faster in the subjects supplemented with ST11 compared to the placebo group. These results indicate three possible mechanisms that are based on the effect of this probiotic on skin sensitivity:
  1. inhibition of the release of neuromediators,
  2. reduced neurogenic inflammation and
  3. Improvement of the skin barrier function.
    4. A fourth mechanism could be an interaction between the probiotic and the intestinal mucosa-associated immune system. 6 This includes the release of cytokines (e.g. TGF-Beta) in the blood that can increase or restore the homeostasis and integrity of the skin.
    We stand on the threshold of a much more sophisticated understanding of the therapeutic applications of probiotics, not only for skin diseases, but with a variety of immune -mediated diseases.
    Markers of some components of the natural moisture factor of the skin were measured (e.g. sodium lactate and urea). These markers remained unchanged by the subjects under ST11 and sank under the subjects at the subjects. These results correlated with a significant improvement in the roughness of the facial skin ( p = 0.006) and a similar trend ( p = 0.08) for dry fold in participants, to which ST11 was administered, compared to those who have been given placebo. With ST11 supplemented subjects, compared to the control group, also showed significantly higher TGF beta values.
    The stool analysis showed that ST11 was only found in 10 % of the test subjects a week after the study was completed, which indicates that ST11 had only a very limited ability to persist in the intestine.
    In a recently published overview article, the positive effects of described lactobacillus paracasei subsp. paracasei ntu 101, including the treatment of hyperlipidemia, high blood pressure, protection of the gastric mucosa, allergic diseases, osteoporosis and obesity.
    In recent years there has been a strong research interest in the use of probiotics in many diseases, including skin diseases such as atopic dermatitis, psoriasis, acne and rosacea. 8-11 There are also many questions left, including the question of dosage. A current overview summarizes the current level of knowledge for the effective dosage of different probiotic tribes that are used in various diseases.
    This study by Gueniche and Philippe is an important memory for doctors of the contribution of intestinal health to skin diseases. Their results underpin the concept of an approach to treatment that is directed from the inside to the outside and from the outside and from the outside in frequent skin diseases such as atopic dermatitis, psoriasis and acne. In order to provide comprehensive care for patients with sensitive skin, probiotic trunks with proven benefits should be selected for these diseases and ideally prescribed in demonstrably effective doses. We stand on the threshold of a much more sophisticated understanding of the therapeutic applications of probiotics not only for skin diseases, but also with a variety of immune -mediated diseases, which are closely linked to the fact that the majority of our immune system is in them.
    Despite the consideration of many potentially confusing variables -such as fermented dairy products, systemic drugs that could influence inflammatory reactions, intestinal operations, vegetarian nutrition and nutritional supplements -it would have been interesting to see whether an adaptation to nutritional behavior and/or habits would have been influenced by the results of this study (especially with regard to other fermented foods such as sauerkraut, Cheese, cucumbers, tofu, tempeh, miso and kombucha).

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    3. ibnou-zekri n, Blum S, Schiffrin EJ, from the Weid T. Divergent patterns of colonization and immune response, caused by two intestinal lactobacillus tribes that have similar properties in vitro. immune infect. 2003; 71 (1): 428-436.
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