Suche
Mein Konto
reference
McCann SE, Thompson LU, Nie J, et al. Dietary lignan intake in relation to survival in women with breast cancer: the Western New York Exposures and Breast Cancer (WEB) Study.Breast cancer treatment.2010;122(1):229-235.
design
Statistical analysis of the data collected on the dietary habits of women with breast cancer. Diet in the 12–24 months before diagnosis was assessed using a comprehensive food frequency questionnaire, and confounding factors were identified using an epidemiological interview and abstracted clinical data. Lignan intake was calculated using published food composition data.
Participants: 1,122 women aged 35–79 years diagnosed with breast cancer between 1996 and 2001. The data were collected as part of a study on lifelong alcohol consumption and breast cancer (WEB study).
Study methodology
The relationship between dietary lignan intake and survival was analyzed. Vital status was followed until the end of 2006. Comprehensive food questionnaires were used to track diet for one to two years prior to initial diagnosis. Lignan intake was calculated using current food composition tables. Hazard ratios (HR) for dietary lignan intake with all-cause mortality and breast cancer mortality were calculated.
Result measure
Vital status (alive or deceased)
Key findings
Postmenopausal women who consumed the most lignans had a significantly lower risk of dying from any cause, particularly breast cancer, than women who consumed only small amounts of foods containing lignans. Comparing the upper and lower quartiles of lignan intake, there was a 51% reduction in all-cause mortality (HR 0.49, 95% CI: 0.26-0.91) in those who consumed the higher amounts of lignan. These women had a 71% lower risk of dying from breast cancer (HR 0.29, 95% CI: 0.11-0.76). A high intake of dried beans (HR 0.61, 95% CI: 0.36-1.03) may also have reduced the risk of all-cause and breast cancer mortality (HR 0.53, 95% CI: 0.24-1.14), although these numbers did not reach statistical significance.
Effects on practice
This is the first work to examine the association between lignan intake before breast cancer diagnosis and the risk of death. These results suggest that we should actively promote the consumption of lignan-containing foods, especially in postmenopausal women.
However, if incorporating some specific foods high in lignans into the diet can reduce breast cancer mortality by even a fraction of the amount shown in these data, it is definitely worth a try.
Since data from the Women's Healthy Eating and Living (WHEL) study was published suggesting that a diet high in fruits and vegetables and low in fat has little impact on breast cancer prognosis, researchers and clinicians have tried to define what is "good." The diet should be intended for patients at risk of breast cancer or who have been diagnosed with breast cancer became."1Promoting high lignan intake is easier said than done because few patients understand what a lignan is and what foods contain it. For the women participating in this study, the main dietary sources of lignans were brown bread, peaches, coffee, broccoli, and winter squash. Other foods are far better sources. While coffee can contain up to 30 µg/100 ml, 100 grams of kale contains several thousand µg of lignans. Flax seeds contain over 300,000 µg/100 grams and sesame seeds contain almost 40,000 µg/100 grams.2
In McCann's study, average lignan intake was 244 µg/day. In postmenopausal women, consumption of <155 mcg/day resulted in an HR for all-cause and breast cancer mortality of 1.00. As consumption increased, heart rate decreased; The lowest risk of death was found in women who consumed more than 318 mcg per day. Achieving these values should be relatively easy to achieve. Doctors and patients may find a useful table of lignan content in foods at: www.dietaryfiberfood.com/lignan.php
This study was not a clinical trial; Maybe that's why these results seem almost too good to be true. However, if incorporating some specific foods high in lignans into the diet can reduce breast cancer mortality by even a fraction of the amount shown in these data, it is definitely worth a try.
For more research on integrative oncology, click here Here.