Study: maternal bisphenol A and miscarriage risk
Study: maternal bisphenol A and miscarriage risk
Reference
lathi rb, Liebert Ca, Brookfield KF, et al. Conjugated bisphenol A in the maternal serum in connection with the risk of miscarriage. fertilize sterile. 2014; 102 (1): 123-128.
Design
retrospective cohort prospectively collected serum samples.
participant
A total of 115 pregnant women were examined who could be treated at Stanford Fertility and Reproductive Medicine Clinic in Palo Alto, California, due to infertility or repeated loss of pregnancy; 47 had live births and 68 experienced a miscarriage in the first trimester. The women were similar in terms of age, body mass index, mirror of the follicle-stimulating hormone on day 3 and smoking status. In order to evaluate the frequency of unexplained miscarriages, women with abnormal karyotype, uterine anomalies, thrombophilia, autoimmune diseases and uncontrolled diabetes were excluded.
Study intervention
Serum samples from the 4th to 5th week of pregnancy stored were analyzed on the concentration of conjugated serum bisphenol A (BPA)primary result dimensions
Living birth rate, miscarriage rate in the first trimester and karyotype of the embryo in the event of miscarriage.
most important knowledge
of the 115 women included in the study had 47 living births and 68 suffered a miscarriage (46 aneuploids and 22 euploids). The middle conjugated BPA values were higher (0.101 ng/ml) in women who had suffered miscarriage than in women who had a livelihood (0.075 ng/ml). p = 0.014). Women whose serum BPA level was in the highest quartile had a 83 % higher risk of miscarriage in the first trimester than women with a serum BPA level in the lowest quartile.
effects on practice
In this study, conjugated BPA was associated with a higher risk of miscarriage in the first trimester. BPA is an endocrine-acting chemical that can affect the production, metabolism and the effect of hormones that are involved in reproduction and embryonic development. 1 BPA occurs in the lining of food doses made of metal, thermobon paper, food and beverage adhesive made of plastic, dental sealing agents and medical devices. The National Health and Nutrition Examination Survey collected urine samples of 2517 people over 6 years and found detectable BPA values in 93 % of the samples, which indicates widespread BPA exposure. Brought. 3.4 Earlier animal studies have shown that a low-dose BPA exposure can increase meiiotic errors in ripening ovary foils of mice. 5 as well as a changed expression of the endometrial progesterone receptor for non-human primates.
In previous studies on determining the BPA levels in the serum, concerns have been expressed that the process of taking blood itself caused a BPA contamination; However, this study deals with the concerns of contamination by measures conjugated BPA, which was subjected to glucoronidation in the human liver. Since earlier animal studies have shown that periconceptual BPA exposure has a negative impact on the health of the endometrium and follicle development, another strength of this study is that they measured the serum BPA levels during the early pregnancy to determine the effects of the peri-implantive BPA exposure on the miscarriages.
Future studies should examine the connection between embryo quality and miscarriage rate in relation to male BPA exposure. Naturopathic doctors who offer prenatal care and treat patients with repeated loss of pregnancy should consider how important it is to avoid environmental pollution such as BPA and other endocrine disruptors in order to improve the health of the embryo and reduce the risk of miscarriage.
- Vandenberg LN, Colborn T., Hayes TB, et al. Hormones and endocrin -looking chemicals: low -dose effects and non -monotonous dose reactions. endocr rev. 2012 (3): 378-455.
- National Institute for Environmental Health Sciences. National toxicology program. Bisphenol A (BPA). Available around: (link removed). Access on September 8, 2014.
- Maffini MV, Rubin BS, sunshine C, Soto Am. Endocrine disruptors and reproductive health: the case of bisphenol-a. mol cellendocrinol. 25. July 2006; 254-255: 179-186.
- Rochester jr. Bisphenol A and human health: a review of literature. Reprod toxicol. 2013 Dec; 42: 132-155.
- Susiarojo M, Hassold TJ, Freeman E, Hunt Pa. Bisphenol A-exposure in the uterus disturbs the early oogenesis on the mouse. Plos Genet. 2007; 3 (1): E5.
- Aldad TS, Rahmani N, Leranth C, Taylor HS. Bisphenol-A exposure changes endometrial progesterone receptor expression in non-human primates. fertilize sterile. 2011; 96 (1): 175-179.