Study: Melatonin treats H-pylori and stomach ulcers
Study: Melatonin treats H-pylori and stomach ulcers
Reference
Osadchuk Ma, Sibriaev aa, Kireeva NV, Kvetno im. The influence of melatonin in the combined treatment with antibelic material therapy on the immunohistochemical properties of gastric epitheliocytes of patients with duodenum ulcers. Klin Med (Moscow). 2012; 90 (12): 48-52.
Design
An open clinical study that added melatonin to a standard treatment protocol Helicobacter pylori infection: The clinical results were compared with that comparable controls.
participant
100 patients with ulcus duodeni (du), 30 with chronic non -Atrophic gastritis (CNAG), 30 with chronic atrophic gastritis (CAG) and 12 healthy subjects. All patients with DU and CNAG were morphologically confirmed Helicobacter pylori infection. The patients with DU were divided into two groups, each of the age -appropriate subjects with endoscopic, morphological and immunohistochemically identical characteristics.
study medication and dosage
Patients of group 1 received a conventional 7-day treatment Helicobacter pylori included omeprazole (20 mg 2x/day), Clarithromycin (500 mg 2x/day) and amoxicillin (1000 mg 2x/day). Group 2 received the same treatment with the addition of melatonin (3 mg before going to bed). Patients in Group 1 continued Omeprazole and those in group 2 Omeprazole plus melatonin for a total of 2 months. Healthy subjects and patients with Cag.
target parameter
All patients were subjected to fibrogastroduodenoscopy (FGDS) in weeks 2 and 4. Immunohistochemical studies for endotheline 1 and melatonin-positive cells were carried out. The apoptotic activity of the mucosal epitheliocytes from the antrum of the stomach was measured before and 6 weeks after the start of therapy.
most important knowledge
The addition of melatonin to the standard treatment protocol for Helicobacter pylori increases the effectiveness of Helicobacter pylori elimination and accelerates the DU healing. A two -month therapy with omeprazole plus melatonin normalizes the healing markers more effectively than treatment with omeprazole alone.
effects on practice
melatonin should now be considered during treatment Helicobacter pylori stomach and duodenum ulcers as well as gastrointestinal reflux disease.
Many patients know that melatonin can alleviate insomnia, but only a few are aware of its positive effect on the gastrointestinal tract. We only mean the hormone by melatonin that is produced by the pineal gland in the brain, but far more melatonin is actually produced by the enteroendocrine cells that line the digestive tract.
The stool habits follow a clear circadian rhythm, and melatonin regulates this time. Food intake of L-tryptophan increases the melatonin level in the blood, even in animals to which the pineal gland has been removed. L-tryptophan is converted into serotonin, which in turn is converted into melatonin. The nightly increase in melatonin comes from the pineal gland, but the gastrointestinal tract maintains the basic values. The melatonin level in the intestine is 10 to 100 times higher than in the blood. 1
This is not the first study that reports on the benefit of melatonin in the treatment Helicobacter pylori . In two studies published in 2011, Celinski et al. They gave all patients 20 mg omeprazole twice a day and then added either melatonin (5 mg 2x/day) or tryptophan (250 mg 2x/day). Both melatonin and tryptophan accelerated the healing compared to Omeprazole alone.
A number of reports indicate that melatonin could be useful in the treatment of gastroesophageal reflux disease (Gerd). For the first time, De Souza Pereira drew us aware of this, who in May 2006 in a letter to the publisher of the magazine for pineal gland research described a 64-year-old woman whose Gerd gut to a formula with melatonin (6 mg). Later in the same year, de Souza Pereira reported on the results of a clinical study in which 176 patients received this melatonin -containing product and 175 Omeprazole (20 mg). All patients who received melatonin preparations "reported a complete regression of the symptoms after 40 days of treatment." Only 65.7 % of those who received Omeprazole reported a similar improvement.
Madalinski suggested in 2011 that melatonin could protect against the development of "erosive esophagitis". . "Esophageal rectory, barrett esophagus and damage outside the esophagus (including lungs, throat, sinuses, middle ears and teeth)", which are all "main risk factors for esophageal carcinoma".
The advantages of melatonin are not only limited to the esophagus and the stomach, but also extend to the pancreas and liver.
melatonin prevents various forms of gastritis and pancreatitis by activating specific MT2 receptors and absorbs reactive oxygen species (ROS). Melatonin counteracts the increase in ROS-induced lipid peroxidation and at least partially preserves the activity of important antioxidant enzymes such as superoxiddismmutase.
In a study from 2011 with 75 patients with acute pancreatitis, high amounts of endogenous melatonin played a protective role and were associated with a milder course of illness.
melatonin can also protect from the formation of gallstones. It lowers the cholesterol in the bile by inhibiting the cholesterol absorption over the intestinal epithelium and increasing cholesterol into bile acids. 8 In a study with 45 patients with steatohepatitis, melatonin led to a "statistically significant reduction in the GGTP, triglyceride and Proinflammatory cytokine levels ”. 9
The conclusion is simple: with melatonin we have an effective means of protecting and healing the gastrointestinal tract. This study only adds further evidence that support its use.
- Bubenik ga. 34 years since the discovery of gastrointestinal melatonin. j Physiol Pharmacol. 2008; 59 Suppl 2: 33-51.
- Celinski K, Konturek PC, Konturek SJ, et al. Effects of melatonin and tryptophan on the healing of gastrointestinal and duodenum ulcers with Helicobacter pylori infection in humans. J Physiol Pharmacol. 2011; 62 (5): 521-526.
- Celinski K, Konturek SJ, Konturek PC, et al. Melatonin or L-tryptophan accelerate the healing of gastroduodenal ulcers in patients treated with omeprazole. j Pineal res. 2011; 50 (4): 389-394.
- Pereira RDE S. Returning of the symptoms of gastroesophageal reflux disease due to dietary supplements with melatonin, vitamins and amino acids: comparison with omeprazole. j Pineal res. 2006; 41 (3): 195-200.
- Madalinski Mh. Does a melatonin supplement change the course of a gastroesophageal reflux disease? world J Gastrointest pharmacol Ther. 2011; 2 (6): 50-51.
- JWOWEK J, Brzozowski t, Konturek SJ. Melatonin as an organ protector in the stomach and in the pancreas. j Pineal res. 2005; 38 (2): 73-83.
- Beryaev O, Herzog T, Munding J, et al. Protection function of endogenous melatonin in the early course of acute pancreatitis in humans. j Pineal res. 2011; 50 (1): 71-77.
- Koppisetti S., Jenigiri B., Terron MP, et al. Reactive oxygen species and the hypomotility of the gallbladder as destinations for the treatment of gallstones with melatonin: an overview. Dig Dis Sci. 2008; 53 (10): 2592-2603.
- Cichoz-Lach H, Celinski K, Konturek PC, Konturek SJ, Slomka M. The effects of L-tryptophan and melatonin on selected biochemical parameters in patients with steatohepatitis. j Physiol Pharmacol. 2010; 61 (5): 577-580.