Study: Coffee lowers brain tumor risk

Veröffentlicht: 27. Juni 2023, 07:31 Uhr

Von: Natur.wiki Autoren-Team

In der Studie „Kaffee- und Teekonsum und Risiko für Hirntumoren in der Kohortenstudie European Prospective Investigation into Cancer and Nutrition (EPIC)“ analysierten die Forscher den Zusammenhang zwischen dem Konsum von Kaffee und Tee und dem Risiko für Hirntumore. Daten zum Kaffee- und Teekonsum wurden aus 9 Ländern analysiert und mithilfe von statistischen Modellen untersucht. Es wurde ein signifikanter umgekehrter Zusammenhang für das Gliomrisiko bei Personen beobachtet, die ≥ 100 ml Kaffee und Tee pro Tag konsumierten, im Vergleich zu Personen, die < 100 ml/Tag konsumierten. Die Ergebnisse deuten darauf hin, dass Kaffee möglicherweise einen schützenden Effekt gegen Gliome haben könnte … — In the study "Coffee and Tea Consum and Risk for Brain Tumors in the Cohe Orient Study European Prospective Investigation Into Cancer and Nutrition (EPIC)", the researchers analyzed the connection between the consumption of coffee and tea and the risk of brain tumors. Data on coffee and tea consumption were analyzed from 9 countries and examined using statistical models. A significant reverse connection for the gliomal risk of people who consumed ≥ 100 ml coffee and tea a day was observed compared to people who consumed <100 ml/day. The results indicate that coffee could possibly have a protective effect against gliomas ... (Symbolbild/natur.wiki)

In the study "Coffee and tea consumption and risk of brain tumors in the cohort study European Prospective Investigation Into Cancer and Nutrition (EPIC)" analyzed the connection between the consumption of coffee and tea and the risk of brain tumors. Data on coffee and tea consumption were analyzed from 9 countries and examined using statistical models. A significant reverse connection for the gliomal risk of people who consumed ≥ 100 ml coffee and tea a day was observed compared to people who consumed <100 ml/day. The results indicate that coffee could possibly have a protective effect against gliomas and that patients with a malignant gliom should not give up their coffee consumption. It is also pointed out to other studies that point out that coffee and caffeine may have a therapeutic effect in the treatment of gliomas.

Reference

Michaud DS, Gallo V, Schlehofer B, et al. Coffee and tea consumption and risk of brain tumors in the cohort study European Prospective Investigation into Cancer and Nutrition (EPIC). bin J clin nutr. 2010 Nov; 92 (5): 1145-1150.

Design

Data on coffee and tea consumption were analyzed using COX proportional hazard models to determine a connection with the risk of brain tumor.

participant

Nutrition data of 343 cases of gliomas and 245 cases of meningooma from 9 countries were analyzed.
Study "Medicines": reported consumption of coffee or tea.

primary measures

Change of relative risk for gliomas or meningeome with increased coffee and tea consumption.

most important knowledge

A significant reverse connection for the gliomal risk was observed in people who consumed ≥ 100 ml coffee and tea per day, compared to people who consumed <100 ml/day (risk ratio: 0.66; 95 %KI: 0.44; 0.97; p = 0.03). The connection in men (Hazard Ratio: 0.59; 95 %-KI: 0.34, 1.01) was somewhat stronger than in women (Hazard Ratio: 0.74; 95 %-KI: 0.42, 1.31); However, neither of these two later connections achieved statistical significance.

effects on practice

This new data is in line with a number of earlier publications that indicate a strong protective effect as well as possibly a useful therapeutic effect of coffee or caffeine against gliomas. Coffee is often seen negatively in the population and often "abandoned" after a cancer diagnosis. At least in the case of gliomas, coffee can be an advantage and these patients should be prevented from setting their coffee consumption.

Holick et al. already reported in January 2010 that coffee reduced the gliomal risk. In this earlier work, data from three prospective cohort studies were combined to determine 335 gli bums. The consumption of 5 or more cups of coffee and tea per day significantly reduced the risk compared to no consumption (RR: 0.60; 95 %-KI: 0.41–0.87; p (trend) = 0.04). The reverse connection was stronger for men (RR: 0.46; 95 %-KI: 0.26–0.81; p (trend) = 0.03).

other recent studies indicate that coffee, especially caffeine, may protect more than just from gliomas and that both may have a therapeutic value in the treatment of gliomas.

In February 2010, Kang et al. reported that caffeine could be a useful additional therapy against invasive gliomas. After the researchers had shown in various in-vitro tests that caffeine inhibited the migration of glioblastoma cells, they showed in Vivo using a mouse-xenotransplantat model of glioblastomas that caffeine increased the mean survival rate significantly.

caffeine sensitizes gliom cells both compared to ionizing radiation and compared to chemotherapy.

caffeine sensitizes gliom cells from both ionizing radiation and compared to chemotherapy. In February 2010, Sinn et al. will.

A possible explanation for these advantages is that coffee is a gamma agonist of the peroxisoma proliferator-activated receptor (PPR). ^{5 ppar-gamma agonists not only inhibit the growth of brain tumors, 6 You can also brain tumor stem cells inhibit. ⁷}

Interestingly, a number of synthetic PPAR-Gamma agonists are already examined for the treatment of brain tumors. Ciglitazon and Troglitazon, both synthetic PPAR-Gamma agonists, are examined and show promising results. ^{8.9 Apart from all these interesting details, our conclusion should be that gliomatents should drink coffee in which caffeine is still contained. The next time a patient tells you with a malignant glioma that he has given up coffee for health reasons, explain it to him better to drink more than less coffee.
For further research on integrative oncology, click here here.}