Study: Dark chocolate improves mobility in patients with peripheral arterial closure disease

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Reference Loffredo L., Perri L., Catasca E. et al. Dark chocolate acutely improves the car in patients with peripheral arterial closure disease. J am Heart Assoc. 2014 July 2; 3 (4). PII: E001072. Design This was a simply blinded, randomized crossover study. Participants followed this study 20 patients (14 men and 6 women, medium age: 69 ± 9 years), all of whom suffered from peripheral arterial closure disease (PAVK). Study intervention The participants received 40 g chocolate with either 85 % cocoa or 35 % or less cocoa. Primary result measurements The subjects were rated with regard to the middle walking distance (MWD) and the maximum walking time (MWT). In addition, ...
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Reference

Loffredo L., Perri L., Catasca E. et al. Dark chocolate acutely improves acute in patients with peripheral arterial closure disease. j am Heart Assoc. 2014 July 2; 3 (4). PII: E001072.

Design

This was a simply blind, randomized crossover study.

participant

This study followed 20 patients (14 men and 6 women, middle age: 69 ± 9 years), all of whom suffered from peripheral arterial closure disease (PAVK).

Study intervention

The participants received 40 g chocolate with either 85 % cocoa or 35 % or less cocoa.

Primary result measurements

The subjects were rated with regard to the middle walking distance (MWD) and the maximum walking time (MWT). In addition, various blood markers were measured, including epicatechin, isoprostans and nitrogen oxide-related indices. All measurements were carried out at the beginning and 2 hours after taking the chocolate.

Important findings

The consumption of dark chocolate increased the MWD significantly (+11 %; p <. 001), p <0.001) and monostritis oxides (NOX) (+57 %; p <. 001). It also lowered the isoprostan in the serum (‒23 %; p =. 01) and SNOX2-DP ( p <. 001). After eating milk chocolate, no changes in the above -mentioned variables were observed. Epicatechin and its methylated metabolite in the serum only increased significantly after taking dark chocolate.
The idea that doctors can prescribe food to a patient is certainly a great concept, but this study shows how important it is to promote the consumption of high -quality dark chocolate and not any form.
in other words, there was a significant improvement in the MWD (11 %) and MWT (15 %) as well as several blood indices in participants who consumed the darker chocolate compared to those who consumed milk chocolate. In fact, none of the participants who consumed milk chocolate showed an improvement. The use of a food product with pharmacological use in the event of a frequent illness must certainly be examined more precisely. The inclusion of chocolate in the nutrition of people with PAVK seems to be simple therapy that would have a good compliance.

practice implications

A number of studies have shown the advantages of eating dark chocolate in cardiovascular diseases; The high antioxidant activity of dark chocolate is suspected as the main reason for its effect. 1-4 The significant increase is certainly encouraging both the MWD and the MWT from such a small amount of cocoa, especially if you consider that more concentrated extracts are available. Since the study did not indicate whether the chocolate source was biological, it can be assumed that organic sources with its typically superior phytonutrient profile could have even more impact on cardiovascular health.
In the United States, there are more than 8 to 12 million people with pad. 5 A cost-effective, appetizing, non-pavk treatment The PAVK would certainly be of great benefit to you. As is well known, chocolate has a high content of polyphenols that have been shown to protect against oxidative stress and certain types of cancer as well as cardiovascular diseases. 6-9 The idea that doctors can prescribe food to a patient is certainly a great concept, but this study shows how important it is to promote the consumption of high-quality dark chocolate and not any shape. In addition, the patients must be instructed to consume chocolate in organic form, non-typical, non-biological trademarks. Some speculate that concentrated raw extracts from cocoa could prove to be more effective. If you consider that more than half of the population of the United States has high or high/normal blood pressure, this has enormous effects. More research needs to be carried out to educate the best cocoa forms and the ideal concentration.
It is noteworthy that no placebo was used in this study, since the non-dark milk chocolate used up to 35 % cocoa. For future studies I would recommend taking a placebo group with 0 % cocoa. The use of such a placebo would enable researchers to observe a linear effect and to better clarify a dose -dependent reaction. In addition, various cocoa extracts could be used, as there are indications that raw cocoa and/or organic forms can have even larger advantages.

  1. Monahan Kd. Effect of taking cocoa/chocolate on the river-mediated dilation of the brachial artery and its relevance for cardiovascular health and illness in humans. Arch Biochem Biophys. 2012; 527 (2): 90-94.
  2. Monahan KD, Feehan RP, Kunselman AR, Preston AG, Miller DL, Lott Me. Dose -dependent increase in river -mediated dilation after acute cocoa intake in healthy older adults. J Appl Physiol. 2011; 111 (6): 1568-1574.
  3. Balzer J, Rassaf T, Heiss C, et al. Persistent advantages of the vascular function by flavanol -containing cocoa in treated diabetics in a double -blind, randomized, controlled study. j am Coll Cardiol. 2008; 51 (22): 2141-2149.
  4. Farouque HM, Leung M, Hope Sa, et al. Acute and chronic effects of flavanol -rich cocoa on the vascular function in patients with coronary heart disease: a randomized, double -blind, placebo -controlled study. Clin SCI (London). 2006; 111 (1): 71-80.
  5. al mahameed A. peripheral arterial closure disease. Available around: http://www.clevelandclinicmeded.com/Medicalpubs/cardiology/peripheral--disese/ . Accessed on January 5, 2015.
  6. Meng CC, Jalil AM, Ismail A. Phenol and theobroming-based commercial dark, milk and white chocolate in the Malaysian market. molecules. 2009; 14 (1): 200-209.
  7. Andujar I, Recio Mc, Giner RM, Rios Jl. Cocoaopolyphenols and their potential advantages for human health. oxid med Cell Longev. 2012; 2012: 906252. EPUB October 24, 2012.
  8. Stoner GD, Muhktar H. Polyphenols as a chemopepentive remedy for cancer. J Cell Biochem Suppl. 1995; 22: 169-180.
  9. Galleano M, Oteiza Pi, fraga cg. Cocoa, chocolate and cardiovascular diseases. j cardiovasc pharmacol. 2009; 54 (6): 483-490.