Study: Curcumin reduces PMS symptoms
Study: Curcumin reduces PMS symptoms
Reference
khayat s, fanaei h, kheirkhah a, et al. Curcumin alleviates the severity of the symptoms of the premenstrual syndrome: a randomized, double -blind, placebo -controlled study. Supplement Ther Med . 2015; 23: 318-324.
Design
randomized, double -blind, placebo -controlled clinical study
participant
The study included 70 healthy premenopausal women with regular menstruation, which suffered from symptoms of the pre -trial syndrome (PMS) and received curcumin (n = 35) or placebo (n = 35).
Intervention
Every participant received 7 days before menstruation and 3 days after the start of the menstruation for 3 consecutive cycles every 12 hours every 12 hours (a total of 200 mg/day curcumin or identical placebo) and recorded the severity of their symptoms by a daily questionnaire.
target parameter
The questionnaire evaluated the severity of PMS based on 3 categories: mood symptoms, physical symptoms and behavioral features. The mood symptoms included unrest, irritability, fear, depression, sadness, crying and feelings of isolation. The physical symptoms included back pain, headache, breast tension, weight gain, abdominal pain, swelling of the extremities, muscle stiffness, gastrointestinal symptoms and nausea. The behavioral features assessed included fatigue, lack of energy, insomnia, concentration disorders and appetite changes. The severity of the symptoms was evaluated with (0) freedom of symptoms, (1) mild symptom that does not affect daily activity, (2) moderate symptom, which affects daily activity, and (3) severe symptoms that hinder daily activity. PMS was diagnosed in women with at least 5 symptoms.
important knowledge
of 70 participants could not complete 4 women in the placebo group and 3 in the curcumin group.
The curcumin group experienced a significant reduction in behavior (22.8 ± 17.4 to 9.1 ± 5.49, p <00001), physically (41.4 ± 21.6 to 18.13 ± 10.92, p <0.0001) and mood (37,8 ± 18.3 to 15.13 ± 7.48, p <0.0001) points after the intervention. The placebo group experienced a significant reduction in physical symptoms (46.7 ± 26.8 to 38.50 ± 20.27, p <0.0425), but no significant difference in behavioral and mood values. Overall, the total PMS score in the intervention group had dropped significantly from 102.06 ± 39.64 to 42.47 ± 16.37 ( p <0.0001), while this value did not change significantly in the placebo graduate.
practice implications
This article is the first to be known to this author to examine curcumin on PMS, which is surprising in view of the known effects of curcumin on neurotransmitter levels and inflammation, both of which are involved in the pathophysiology of PMS. Summarize the release of neurotransmitters and inflammation, as well as the studies in which the effects of curcumin are measured on both.
Physical symptoms of PMS are very strongly associated with pain and inflammation channels.
PMS has a variety of symptoms and several underlying mechanisms through which these are created. It has been shown that many of the mood and behavioral symptoms are related to changes in neurotransmitter, including a decrease in noradrenaline, dopamine and serotonin. It is believed that some of these changes are stimulated by the pre -trial decrease in estrogen and progesterone, such as: B. at dopamine, while others have not yet been explained. 2 It was shown in vivo and vitro that curcumin norepinephrin, dopamine and serotonin increased, which could be one of the mechanisms of its positive effect on PMS behavioral and mood symptoms.
Physical symptoms of PMS are very strongly associated with pain and inflammation channels. For example, the Cyclooxygenase-2-Ezym (COX-2) is responsible for the production of Prostaglandin E2, which is known that it plays a role in PMS pathophysiology. Animal studies showed that curcumin regulates the COX-2 gene expression and thereby inhibits prostaglandin production.
naturopathic doctors often turn to the use of phytotherapies, vitamin B6 and magnesium to treat PMS depending on the symptoms available. The addition of curcumin to the treatment protocol in a dose of 100 mg twice a day seems to offer a certain benefit without reported side effects, regardless of the symptom image, and should be considered.
restrictions
The design of this study as randomized, double -blind, controlled study is a strength, even though it had a relatively small sample size and the study participants were limited to students. Larger studies should be carried out to confirm the results. It can also be worthwhile to consider studies that use a consistent dosage compared to acute dosage around the premenstrual time.
- WHelan am, Jurgens TM, Naylor H. Herbs, Vitamins and Minerals in the treatment of premenstrual syndrome: a systematic review. can jlin pharmacol . 2009; 9: 1233-1241.
- Blum I1, Lerman M, Misrachi I, et al. A lack of plasma-norepinephrin cyclicality: increased estradiol during the follicular phase and progesterone and gonadotropins in ovulation in women with a pre-truly syndrome. neuropsychobiology . 2004; 50 (1): 10-15.
- Kulkarni SK, Dhir A. An overview of curcumin in neurological diseases. Indian J. Pharm. Sci . 2010; 72 (2): 149-154.
- Budoff Pw. The use of prostaglandin inhibitors for pre-trial syndrome. j. Reprod. Med . 1983; 28 (7): 469-478.
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