Study: blueberries reduce insulin resistance

Reference

Stull AJ, Cash KC, Johnson WD, Champagne CM, Cefalu WT. Bioactive substances in blueberries improve insulin sensitivity in overweight, insulin -resistant men and women. j nutr. 2010; 140 (10): 1764-1768.

Design

double -blind, randomized and placebo -controlled clinical study.

participant

32 Odipöse, non -diabetic and insulin -resistant subjects of middle -aged both sexes.

evaluation

an 18 units were used for the relative Mediterranean diet, which rated 9 key components of the Mediterranean diet and made it possible to estimate a scor for the relative compliance with the Mediterranean diet.

study medication and dosage

The participants were randomized and consumed for 6 weeks either a smoothie with 22.5 g bioactive blueberry fabrics (n = 15) or a smoothie with the same nutritional value without additives bioactive blueberry substances (n = 17). The blueberry bioactants used were "made from a 50/50 mix of two types of high-bush blueberries, Tifblue (Vaccinium Ashei) and ruble (Vaccinium Corymbosum)." The whole blueberries were freezing, [and] "ground" into a powder. The daily dose corresponded to about 2 cups of fresh whole blueberries.

primary result dimensions

The main indicator was the insulin sensitivity, with hyperinulineemic-euglycemic brackets being used after a 10-hour fasting and standard protocols were followed at the beginning of the study, in the middle and end of the study. Inflammation biomarkers and lipids were measured in the serum before each bracket intervention. The inflammatory markers in the serum included the highly sensitive C-reactive protein (HSCRP), the tumor necrosis factor-A (TNFA) and the monocyte-chemoattractive protein1 (MCP-1).

most important knowledge

daily doses of freezer -dried blueberry powder improved insulin sensitivity to the end of the study, without significant changes in obesity, energy intake or inflammatory biomarkers. The average change in insulin sensitivity improved in the blueberry group [1.7 +/- 0.5 mg.kg ffm (-1) .min (-1)] compared to the placebo group [0.4 +/- 0.4 mg.kg ffm (-1)] (p = 0.04).

effects on practice

blueberries are a new and attractive addition to our current range of things that improve insulin sensitivity. The most proven and safest methods for increasing insulin sensitivity are still movement and weight loss. Weight reduction reduces insulin resistance in both children and adults, especially in combination with movement. 1, 2, 3

The addition of large amounts of grain fibers to nutrition also increases insulin sensitivity. In an experiment, a little more than 1 ounces of oats per day led to significant changes in insulin sensitivity after only three days. 4 Fill -rich rye bread has a similarly positive effect and has been shown to reduce cholesterol levels. ^{5, 6 Every weight gain during these experiments destroys the benefits. 6}

A low vitamin D level affects insulin sensitivity. ^{8 A study published in April 2010 questions whether vitamin D will be useful for the general population; Low vitamin D levels were only associated with insulin sensitivity in African-American women, not with Caucasian women. 9 Apparently there is no reason not to add vitamin D to all patients, but in part of the patient it can prove to be negative in insulin sensitivity.}

Apparently there is no reason not to add vitamin D for all patients, but in some of the patients it can prove to be negative on insulin sensitivity.

The same could also apply to chrome. For years we have been giving patients with blood sugar problems. A double -blind, placebo -controlled study published by researchers at Yale University in July 2009 questions this practice. After a 6-month supplementation with either 500 or 1,000 µg/day, insulin sensitivity was no different from those who had taken placebo. The authors came to the conclusion: "A chrome supplement does not seem to improve the insulin resistance or the impaired glucose metabolism in patients with a risk of type 2 diabetes, and it is therefore unlikely that they will reduce the risk of diabetes." Chrome react. In this study, a clinical improvement was "more likely with insulin-resistant subjects who had an increased sober glucose and A (1c) mirror." 11 The participants of the Yale study only had a high risk of type 2 diabetes. Those in the Louisiana study who answered already had diabetes, and the worse their illness was, the better the reaction.

Until the proof of the opposite, we assume that fresh or frozen blueberries improve insulin sensitivity as effectively as the powder used in the current study. Since it is assumed that blueberries help with a variety of health disorders, it makes sense to recommend a large number of patients, especially those with reduced insulin sensitivity, the daily consumption of blueberries.