Study: Bisphenol A and pregnant women

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In a case control study, the researchers measured the bisphenol A (BPA) mirror in two groups of pregnant women-those with the diagnosis of fetal malformation and those without. Surprisingly, the women with healthy fetuses showed higher rates on conjugated BPA, which could indicate that women who are poorly metabolizing the BPA have fetuses with developmental disorders. This paper is part of our special environmental medicine. Read the entire issue below. Reference Guida M., Troisi J., Ciccone C., et al. Bisphenol A and congenital developmental disorders in humans. Mutat res. April 2015; 774: 33-39. EPUB March 6, 2015. Design case control study participants one hundred and fifty pregnant women were divided into two groups: ...
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In a case-control study, the researchers measured the bisphenol A (BPA) mirror in two groups of pregnant women-those with the diagnosis of fetal malformation and those without. Surprisingly, the women with healthy fetuses showed higher rates on conjugated BPA, which could indicate that women who are poorly metabolizing the BPA have fetuses with developmental disorders.

This paper is part of our special environmental medicine. Read the entire issue below.

Reference

Guida M., Troisi J., Ciccone C., et al. Bisphenol A and congenital developmental disorders in humans. mutat res. April 2015; 774: 33-39. Epub March 6, 2015.

design

Case control study

participant

fifty -one -and -fifty women were divided into two groups: the case group (n = 101) consisted of women with a secure diagnosis of a fetal malformation and the control group (n = 50) consisted of women who visited the hospital during routine examinations.

Study intervention

The overall mirror of free and conjugated bisphenol A (BPA) was measured in the blood of the participants using gas chromatography mass spectrometry with isotropic dilution.

important knowledge

The average value of free BPA was almost three times higher in chromosome misalignments and almost twice higher in non -chromosomal malformations of the central and peripheral nervous system than in the controls. Conjugated BPA mirrors, which were higher in the control group, support the hypothesis that a reduced ability to metabolize the chemical in the mother can change to the occurrence of malformations in the fetus.

practice implications

Point out that BPA is an endocrine disruptor who disturbs the programming of complex endocrine signaling pathways during the development in the womb and in the early childhood. 1-3 This is one of the first studies carried out in humans to examine the correlation between BPA in maternal blood and fetal malformations. The most interesting observation from the study is that the control group with normally developed fetuses had higher concentrations on BPA conjugate than the case group of women with deficient fetuses. This finding reflects the ability of the control group to metabolize BPA into its inert form. The conjugated forms of BPA have no endocrine effect and do not change the biological processes of fetal development. Non -conjugated BPA binds to plasma proteins and intervenes in the endocrine system, which leads to malformations of the fetus.
one of Matsumoto et al. In 2002, BPA pharmacokinetics carried out that the end result of BPA metabolism via the kidneys is eliminated as water-soluble formation of BPA-Glucuronide, which is carried out via the hepatic glucuronosyl transferase (GT). Sulfotransferase arise, which leads to the formation of BPA sulfate. The hepatic GT activity is dependent on age and much lower for fetuses and newborns. 5 The main path of the BPA metabolism in fetuses and newborns runs via sulfate.
Another focus in the care before conception and the assessment of infertility must be placed on determining how well a woman can adequately remove toxic loads.
This study illustrates the environmental medical concept of full body load. The accumulation of the toxins over time predisposes individuals to be more susceptible to chronic diseases and diseases. Reports of reduced fertility in the past decade can be attributed to long-term BPA exposure that was associated with a decline in the percentage of oozytes that develop during Meiosis II. 8.9 The mechanism of action from BPA on OOZYTE remains unknown. Due to the results of the study, the authors create the hypothesis that the reduced ability to metabolize BPA could predispose a woman for pregnancies with fetal chromosome anomalies. These women can be classified as "bad metabolisers" that were more susceptible to the endocrine disorder of BPA. The results of the study also confirm the correlation between the blood concentrations of overall BPA in women with fetuses with chromosomal anomalies compared to women with normally developed fetuses, as from Yamada et al.
It is imperative that doctors inform patients about the sources of BPA exposure in order to reduce or eliminate exposure to potential damage. The exposure to BPA is omnipresent: The substance can be found in plastics, linings of doses for food and drinks, thermal receipts, dental seals and self -adhesive labels. 11 A significant result of this study emphasizes that those with normal biotransory processes or the ability to detoxify do not seem to show the same harmful effects of BPA Like those who cannot eliminate exogenous connections as well. Another focus in the care before conception and the assessment of infertility must be placed on determining how well a woman can adequately remove toxic loads.
nutrients that are administered before conception should concentrate on all aspects of biotransformation, in particular on the hepatic GT activity in order to improve the clearance of BPA to its non-active forms and prevent damage to the developing fetus. Another note to be emphasized is that the BPA substitutes Bisphenol-S (BPS) and Bisphenol-F (BPF) can also have the same endocrine effects as BPA, since they are just as hormonal. 12 BPS and BPF can be found in the same sources-personal care products, paper products and food.
This study is a wake-up call for the role of BPA exposure to fetal development and human reproduction. Further investigations are justified to determine their effects, if available, on male fertility and their contribution to the fetal malformation.

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