Study: Bisphenol A in beverage computers can increase blood pressure

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Reference Bae S, Hong Yc. Exposure to Bisphenol A by drinking can drinks increases blood pressure: randomized crossover study. Hypertension. 2015; 65 (2): 313-319. EPUB December 8, 2014. Designed crossover study participants in the study took 60 volunteers from a community center in Seoul, South Korea. The participants were older than 60 years, the average age was 73.1+4.2 years. The participants were mainly women with only 4 male participants. The study excluded people with a history of heart disease, cancer, liver diseases or endocrine diseases. Among the participants reported 27 of high blood pressure and 9 of diabetes mellitus. From the patients with high blood pressure, 1 ...
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Reference

Bae S, Hong Yc. Exposure to bisphenol A by drinking can drinks increases blood pressure: randomized crossover study. hypertension. 2015; 65 (2): 313-319. EPUB December 8, 2014.

Design

randomized crossover study

participant

60 volunteers from a community center in Seoul, South Korea, took part in the study. The participants were older than 60 years, the average age was 73.1+4.2 years. The participants were mainly women with only 4 male participants. The study excluded people with a history of heart disease, cancer, liver diseases or endocrine diseases. Among the participants reported 27 of high blood pressure and 9 of diabetes mellitus. 1 participant received medication from the patients with high blood pressure. All diabetics were treated for this disease.

Study intervention

The participants visited the study center on 3 different occasions with more than 1-week intervals between every visit. All participants fasted more than 8 hours before visiting the place of study at 9:00 a.m. They were randomized to drink soy milk every time in 1 of 3 different container combinations: 2 glass bottles, 2 cans or 1 can and 1 glass bottle. The participants ate or drink no other food for 2 hours after eating the soy milk. Bisphenol A (BPA) concentration in urine, blood pressure and heart rate variability were measured 2 hours after each intake.

important knowledge

The study showed that participants who drank with BPA doses, compared to participants who drank from glass bottles, had an increased BPA concentration in the urine of more than 1600 % and a systolic blood pressure increased by 4.5 mmHg. There was no statistically significant difference in heart rate variability between the study groups.

practice implications

This study claims that a one-time BPA exposure increases systolic blood pressure acutely. This is in accordance with earlier epidemiological studies that have shown a positive connection between BPA concentration and blood pressure. 1-3 The BPA concentration measured in the doses was 8.22 + 0.82 µg/l compared to 0.31 + 0.01 µg/l in the glass bottles. In earlier epidemiological studies, cumulative BPA exposure-longer than 1 week in a study and over 5 consecutive days in another-an increased BPA concentration in urine with cardiovascular diseases (CVD).
In patients with increased blood pressure, doctors must take bisphenol A into account as the underlying factor and inquire about sources of exposure.
The results of the present study have considerable clinical implications, since BPA could be an underlying factor for high blood pressure. BPA is generally not considered or evaluated as a risk factor for cardiovascular diseases in the clinical environment. A one-off contact with a BPA-containing drink increased the blood pressure significantly, which means that patients who have repeatedly drunk from several doses and plastic bottles or eaten in the course of time may unintentionally increase their risk of heart disease and peripheral arterial disease. Despite the fast metabolism and the quick clearance of BPA, it is a well -known endocrine disruptor whose accumulation has a disadvantageous effects on the reproductive and/or endocrine system.
In patients with increased blood pressure, clinicians must take BPA into account as an underlying factor and inquire about sources of exposure. Studies about whether patients eat dosens soups, drink from plastic or polycarbonate containers, consume packaged food or handle the cladding with BPA can reveal an underlying contribution to blood pressure. 7.8 The reduction in exposure to BPA and the promotion of its avoidance can improve results in patients with high blood pressure and cardiovascular disorders lead.

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