Study: Bio -available curcumin supports healthy patients in taking iron preparations
Study: Bio -available curcumin supports healthy patients in taking iron preparations
This study was about examining the effects of the simultaneous administration of iron and bio -availability curcumin for systemic inflammation and gastrointestinal side effects. The researchers recruited healthy participants and carried out a double -blind, placebo -controlled, randomized study. The participants received different combinations of iron and curcumin, and various markers for inflammation and oxidative stress were measured. The results showed that the combination of high -dose iron and curcumin led to a significant reduction in certain systemic inflammatory markers. However, a connection between the use of high -dose iron and darker chair was also observed, which could be compensated for by curcumin. This study provides indications that a combination of iron and curcumin may have anti -inflammatory properties and can reduce gastrointestinal side effects.
Details of the study:
reference
tiekou Lorinczova H, Begum G, Temouri L, Renshaw D, Zariwala Mg. The simultaneous administration of iron and bioavailable curcumin reduced the values of systemic markers for inflammation and oxidative stress in a placebo -controlled, randomized study. nutrients . 2022; 14 (3): 712.
study goal
to determine whether the simultaneous administration of iron (iron sulfate) with an bio -available form of curcumin systemic inflammation and/or gastrointestinal (GI) Side effects reduces
Key to take away
Highly dose of iron can lead to darker bowel movements and curcumin can compensate for this known effect.
design
double -blind, placebo -controlled, randomized study
participant
The researchers recruited participants who were generally healthy and whose ferritine levels were in the normal area (> 15 ng/ml). They recruited 155 healthy participants (79 men, 26.42 years ± 0.55; and 76 women, 25.82 years ± 0.54).
The ethnic data of the participants include: Caucasian 64.3 %, Asians 22.1 %, Africans 3.2 %, middle or South Americans 2.6 %and other 7.8 %.
The researchers exclude people with low hemoglobin value, known diseases, taking dietary supplements or medication, excessive alcohol consumption or chronic gastrointestinal symptoms, eating disorders, mental illnesses or hypo/hypertensive blood pressure measurements. A participant was excluded from the data analysis due to a high body mass index (> 40 kg/m).
interventions
The process consisted of 5 parts:
- iron placebo and curcumin-placebo
- low-dosed (18 mg) iron and curcumin-placebo
- low -dosed iron and curcumin
- High-dose (65 mg) iron and curcumin-placebo
- High -dose iron and curcumin
The researchers used iron sulfate as a form of iron and administered curcumin (hydrocurc) in a dosage of 500 mg/day. The instructions included carrying out the intervention at least 1 hour before or 2 hours after eating food. The duration of studies was 6 weeks.
study parameters
The biochemical assessment included hemoglobin, serum feritin, C-reactive protein (CRP), serum iron (FE), total iron binding capacity (TIBC), transfer-saturation (TS) and unsaturated iron binding capacity (UIBC), interleukin 6 (IL). -6), interleukin 10 (IL-10), interleukin 1 beta (IL-1b), tumor necrosis factor (TNF) and Thiobarbituric acid-reactive substances (TBARS).
The subjective assessment included the Fatigue Severity Scale (FSS), the fatigue visual analog scale (F-VAS) and the questionnaire for assessing the gastrointestinal symptoms about oral iron supplement as well as a question in connection with dark or black chair.
The ratings were carried out at the beginning of the course, in the middle and at the end point and the participants filled out the GI questionnaire online every day.
primary result
The primary endpoints were markers for systemic inflammation: IL-1, IL-6, TNF and TBARS. All other measurements, both subjective and lenses, were secondary.
most important knowledge
There was a significant reduction in the middle TNF plasma level (0.65 pg/ml ± 0.17). p = 0.0018) When comparing the middle values with the middle end point values in the high-dose iron and curcumin arm. A significant reduction in the middle plasma TNF (0.35 pg/ml ± 0.13, p = 0.0288) also occurred in the arm with low dose-dose iron and curcumin as well as in the arm with high-dose iron and placebo (0.39 pg/ml ± 0.15, p = 0.0363).
When comparing the double placebo group with the group, which took 65 mg of iron and a curcumin placebo, there was a significant connection with a darker chair ( p = 0.002, exact fisher test).
Eventually there was a significant reduction in IL-6 (0.06 pg/ml ± 0.02, p = 0.0073).transparency
The donor, gencor pacific Ltd., Whoever produces hydrocurc was involved in the study design process, but not in data acquisition or analysis. The authors do not indicate any further conflict of interest.
effects and restrictions for practice
The examination of healthy subjects plays a role in determining the security of interventions and the recognition of subtle changes. However, this makes it difficult to recognize changes. A technique that the researchers used included the implementation of a subgroup analysis of participants with low ferritin mirrors, which were either below 30 ng/ml or below 50 ng/ml. The reason for these limit values is to achieve a greater sensitivity than the recommendation of the World Health Organization of 15 ng/ml. 3-4 For values under 50 ng/ml, there may be reduced bone marrow stores or a latent iron deficiency. Colloquially referred to as suboptimal values.
From a practical perspective, this study has significant restrictions because young, healthy and non -obese participants are recruited with normal iron status. In clinical practice, a higher -dose iron supplement without objective needs is rare. In essence, the researchers were concerned with investigating the inflammation in patients who do not show any obvious signs or symptoms of inflammation.
One of the most common objective inflammatory markers in clinical practice is the C-reactive protein, an acute-phase protein made by the liver. CRP increases in relation to IL-6 and is often increased due to systemic inflammation or infection. The Marker may not be sensitive enough if the inflammatory cascade is already normal in a healthy population.
However, changes in the plasma-il-6 were observed in the arm with high-dose iron and curcumin ( p = 0.0073) in the subgroup analysis of people with ferritin mirrors over 30 ng/ml. Similar effects were observed with a circulating TNF. IL-1B and IL-10 were not influenced by the intervention. While these cytokines and inflammatory indicators in research are helpful, they are not often assessed in clinical practice.
The serum iron level, which is routinely measured in practice, remained unchanged during this intervention; This is not surprising in view of the population examined. However, the ferritin levels were influenced both in the curcumin placebo arm and in the curcumin-active arm, but in an inconsistent way. In the arm with high -dose iron and curcumin and placebo, Ferritin increased more significantly than in the arm with high -dose iron and curcumin. This could tempt the reader to assume that bioavailable curcumin could inhibit iron absorption or storage; In the arms with low-dosed iron and analysis with low normal ferritin (> 30 ng/ml), however, the arm reacted more with active curcumin than the placebo arm. In addition, no inhibitory effect could be determined in an earlier study with the same material.
From the point of view of the practical application, this study has significant restrictions because young, healthy and non -obese participants are recruited with normal iron status. ” The subjective fatigue assessments did not differ significantly during the entire study between the poor. Perhaps the most convincing and clinically useful consideration of this study was the change in the darker chair. For patients who need a higher dose or a longer treatment period or reports about darker stool at a lower iron dose, bio -available curcumin seems to be a promising additional recommendation. Since an iron supplement can cause inflammatory side effects, the use of a recognized anti -inflammatory measure makes sense. The curcumin used in this study was Hydrocurc, which is described as an bio -available curcumin product with 85 % curcuminoids. The administration system is patented and can contain processes or materials that are offensive to some patients and/or doctors. Several attempts to improve the pharmacokinetic profile of curcumin and its starting material turmeric were commercialized. Some questions that remain open after this study concern the question of whether other curcumin products have the same or a similar effect as to whether the dose used in this study is best suited and whether the duration of the study is long enough to identify clinically relevant effects. The author is employed by a company that sells turmeric products, but not the product that is the subject of this study, and otherwise does not indicate a conflict of interest. (link removed) disclosure of conflicts of interest
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