Study: fiber, bacteria and colon cancer
Study: fiber, bacteria and colon cancer
Reference
Chen hm, yu yn, Wang jl, et al. Reduced fiber intake and structural change in the intestinal microbiota in patients with advanced colorectal adenoma. am j Clin nutr. 2013; 97: 1044-1052.
Design
observation case control study, cross-sectional study, the patients with the diagnosis of advanced intestinal cancer (A-CRA) assigned to a healthy control group (HC)
participant
For the study, 5632 consecutive patients from 5 medical centers in China who had undergone colonoscopy were selected. Of these subjects, 688 (344 each in the A-Cra- and HC group) filled out the questionnaire for food frequency and provided stool samples.
study parameters
fiber intake, short -chain fatty acids (SCFAS) and intestinal microbiota in patients with advanced colon cancer were compared with the control group.
primary result dimensions
scfas, microbiota, fiber intake in connection with the A-Cra risk
most important knowledge
In this study, several factors were identified that protect against A-Cra, including the consumption of vegetables and large amounts of acetic acid and butyric acid in the chair. A fiber-rich diet increased the number of butyrat and butyrat-producing bacteria. The A-Cra group had significantly lower SCFAS in the chair. The most important SCFA production in the HC group was acetate, followed by Butyrat and propionate.
There was also a significant difference in the intestinal microbiota between the groups. Participants with A-Cra had higher values Enterococcal , streptococcs and bacteroidetes and lower levels of Clostridium , roseburia and eubacterium SPP.
effects on practice
This study confirms what has been reported in several cell culture and epidemiological studies: the right intestinal bacteria, fiber and SCFAS can reduce the growth of colon cancer cells.
The fiber that initiates the SCFA production from the highest level is citrus pectin, soybas, sugar beet fiber, pea fiber, apple pectin and oat fiber. To increase glutathione transfer.
Although further research is required, practitioners could suggest citrus spectators that contain probiotics lactobacillus and bifidobacteria and butyrat to reduce intestinal cancer risk.
Research has also supported the use of probiotics to reduce the growth of colon cancer cells in vitro and vivo. Studies have supported lactobacillus species to reduce the invasion of colorectal cells. tribes showed a reduction in cell proliferation and an increase in the enzyme glutathione S-transferase (GST), which offers a protective advantage against colon cancer.
As far as the fiber is concerned, human data support the use of vegetable fiber, in particular to reduce the risk of developing colon polyps. Another fiber that was examined in animal models is inulin that triggered apoptosis in the food in the food.
Although further research is necessary, practitioners could suggest citrus spectators, which contains probiotics lactobacillus and bifidobacteria and butyrat to reduce intestinal cancer risk. I encourage my patients to eat rich in plant fiber to increase blood pressure bifidobacteria already present in their intestine and thus the SCFA production. These lifestyle and nutritional supplements can provide the right fiber, intestinal bacteria and SCFas to reduce the growth of colon cancer cells and to promote healthy colonocytes.
- Titgemeyer EC, Bourquin LD, Fahey GC JR, Garleb Ka. Fermentability of different fiber sources by human faeces bacteria in vitro. am j clin nutr. 1991; 53 (6): 1418-1424.
- Scharlau D, Borowicki a, Habermann n, et al. Mechanisms of primary cancer prevention by butyrats and other products that arise during the fermentation of fiber conveyed by the intestinal flora. mutat res. 2009; 682 (1): 39-53.
- Hinnebusch Bf, Meng s, Wu Jt, Archer Sy, Hodin ra. The effects of short -chain fatty acids on the phenotype of human intestinal cancer cells are associated with histone hyperacetylation. J Nutr. 2002; 132 (5): 1012-1017.
- Escamilla J, Lane Ma, Maitin V. Zell -Free Surprises of Probiotics lactobacillus Casei and lactobacillus rhamnosus GG reduces the invasion of colon cancer cells in vitro. nutr-cancer. 2012; 64 (6): 871-878.
- Friederich P, Verluur J, van Heumen BW, et al. Effects of the intervention with Sulindac and Inulin/VSL#3 on mucous membrane and lumen factors in the bag of patients with family adenomatous polyposis.