Study: Effects of hyperthermia on severe depressive disorders

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<+>0.001) und zeigten eine signifikante Korrelation mit der Abnahme der MDD-Symptome im Verlauf der Studie (P<0.05). Es wurde auch festgestellt, dass die Veränderungen anderer Zytokine, einschließlich IFN-gamma, IL-1-alpha, IL-1-beta, IL-4, IL-8, IL-10 und TNF, nicht signifikant mit den Veränderungen der Körpertemperatur oder der MDD-Symptome in Zusammenhang standen.<+> Die Studie deutet darauf hin, dass die antidepressive Wirkung der Ganzkörperhyperthermie bei Patienten mit schwerer depressiver Störung mit einer erhöhten Produktion von IL-6 zusammenhängt, was auf eine mögliche Rolle dieses Zytokins bei der Behandlung von Stimmungsstörungen hinweist. Details der Studie: Referenz Flux MC, Smith DG, Allen JJB, et al. Zusammenhang zwischen Plasmazytokinen und …
<+> 0.001) and showed a significant correlation with the decrease in MDD symptoms in the course of the study (p <0.05). It was also found that the changes from other cytokines, including IFN-Gamma, IL-1-Alpha, Il-1-Beta, Il-4, IL-8, IL-10 and TNF, were not significantly related to the changes in body temperature or MDD symptoms. All-body hyperthermia in patients with severe depressive disorder is related to increased production of IL-6, which indicates a possible role of this cytokine in the treatment of mood disorders. Details of the study: Reference Flux MC, Smith DG, Allen JJB, et al. Connection between plasma cytokines and ... (Symbolbild/natur.wiki)

<+> 0.001) and showed a significant correlation with the acceptance of the MDD symptoms in the course of the study (p <0.05). It was also found that the changes from other cytokines, including IFN-Gamma, IL-1-Alpha, Il-1-Beta, Il-4, IL-8, IL-10 and TNF, were not significantly related to the changes in body temperature or MDD symptoms. All-body hyperthermia in patients with severe depressive disorder is related to increased production of IL-6, which indicates a possible role of this cytokine in the treatment of mood disorders.

Details of the study:

Reference

Flux Mc, Smith DG, Allen JJB, et al. Connection between plasma cytokines and antidepressant reaction according to mild full -body hyperthermia with severe depressive disorder. Transl. Psychiatry . 2023; 13 (1): 132.

Study goal

Determination of the effects of the full body hyperthermia (WBHT) on immun parameter and depressive symptoms in patients with severe depressive disorder (MDD)

Key to take

The antidepressant effects of WBHT in the fever area correlate with the induction of interleukin 6 (IL-6) in patients with MDD, which indicates a more complex role of IL-6 in mood disorders.

design

randomized, simply blinded, sham -controlled study

Participant

took part in the study 30 participants aged 18 to 65, who were medically healthy and met the criteria for a serious depressive disorder (Diagnostic and Statistical Manual of Mental Disorders, 4 Th Edition, Textrevision (DSM-IV-TR)) and reached at least 4 weeks before the inscription in the study long a value of 16 or more on the Hamilton Depression Rating Scale (HDRS). The participants did not have to take psychotropic drugs before and during the study.

Intervention

The participants were randomized and received either a single WBHT treatment or a sham treatment. The participants of the study group were heated with a full body hyperthermal device Heckel HT3000 until their inner body core temperature reached 38.5 0 c; Then they were granted a one -hour coincidence. The participants of the false group used the same device, but the session consisted of a mild heating coil, fan sounds and colored lights to simulate WBHT treatment.

rated study parameters

The researchers gave the participants the 17-point HDRS at the beginning of the pretreatment and 1, 2, 4 and 6 weeks after the WBHT/Fein treatment.

The researchers measured cytokines, including interferon (IFN) -Gamma, interleukin (il) 1-alpha, Il-1-Beta, Il-4, IL-6, IL-8, IL-12P70 (heterodimer) and tumor necrosis (tnf; active trimer), in in Plasma at 8:30 a.m. on treatment morning, 30 minutes in study intervention and 1 and 4 weeks after the interventions.

Primary result

The study should examine whether changes in body temperature during WBHT treatment correlate with changes in the MDD symptoms and cytokine levels.

most important findings

In this study correlated WBHT-induced increases in body temperature directly with an increased production of IL-6 after treatment ( p < 0.001). An increased IL-6 production correlated directly with a reduction in the HDRS values ​​( p <0.01).

Transparency

The authors announced their complete sources of financing and affiliation in the first publication of the clinical study.

The funding of this study was carried out by the Brain & Behavior Research Foundation (Independent Investigator Award), the Depressive and Bipolar Disorder Alternative Treatation, the Institute for Mental Health Research, the Braun Foundation as well as Barry and Janet Lang and Arch and Laura Brown. The information from the authors contained no connection with the device used in the study.

Effects on the practice

This study by Michael Flux and his team was the first to try to evaluate the effects of WBHT on the immune function in relation to the symptoms of MDD. The design of the study was unique in that she tried to carry out a sham/placebo treatment in order to minimize the bias of the participants. Early studies on WBHT and depression showed encouraging results in reducing the symptoms of MDD, but were criticized because of the low sample size and the lack of controls.

The researchers of this study had already published the results of the most important results of the clinical study and showed that WBHT significantly reduced the symptoms of MDD. 1 In this publication, the connection between changes in the MDD symptoms and changes in immunological parameters was examined. Specifically, the researchers wanted to find out whether WBHT could reduce inflammatory cytokin markers and, if so, whether they correlate with a symptomatic improvement.

Other studies in the areas of aging and chronic/degenerative diseases have shown that a disorder of the immune hythm is the key to mis -regulation.

Studies on the role of immune function and inflammation at MDD have led to the knowledge that MDD is associated with chronic inflammation. In meta-analysis reviews, an increased mirror of depression was determined in patients with depression TNF-6, IL-13, IL-18, IL-1 receptor antagonist and serum-soluble TNF receptor 2 (StNFR2), together with reduced mirroring of the prointflammatory cytocins Ifn-γ. 3 It has been shown that immunodled therapies such as anti-il-6 and anti-TNF active ingredients improve the symptoms of depression and fatigue in patients. 4 Research the effect of pharmacological active ingredients such as selective serotonin reuptake inhibitors (SSRIS) and serotonin-noradrenalin reuptake inhibitor (SNRIS) on inflammatory cytokines had mixed results. In a meta-analysis of human studies it was found that researchers found that antidepressant il-1 reduce β , il> il-6 and il-10 although the effects across the medication classes are not uniform are.

In this study, most of the inflammatory cytokines were not influenced by WBHT. Only IL-6 showed a significant increase immediately after the WBHT treatment, but normalized in future measurements. It was even more interesting that these observed changes in the IL 6 concentrations correlate directly with improvements in the HDRS scores of the participants. Improving the symptoms was maximum 2 weeks after the WBHT treatment. This was not what the researchers expected, and the results led them to the assumption that acute changes from IL-6 could still have an impact on the mood. A plausible explanation is that the temporary increase in IL-6 is more like an increase in IL-6 caused by physical activity, which is known that it has unique cellular effects compared to chronically high IL-6 effects. The researchers admit that some changes in the inflammatory cytokines may have been overlooked compared to the control group, since the patients in the control group received a sham treatment consisting of mild warming. This mild heating served as a low-temperature WBHT and was ultimately not a real zero treatment control.

This study shows us that we have to think differently about inflammation and chronic diseases such as MDD, which have long been associated with low, chronic, unproductive inflammation. In this study, Flux and his team showed that the MDD symptoms were positively influenced by WBHT by temporary increases in IL-6, while there were no reduction in other inflammatory mediators.

Other examinations in the areas of aging and chronic/degenerative diseases have shown that a disorder of the immune hythm is the key to mis -regulation. A current overview on this topic by Keyu Su et al. summarized the evidence that the loss of the circadian immunehythm is caused by a variety of genetic, epigenetic and metabolic mechanisms and is connected to depression and changed inflammatory cytokin patterns. 7 FUTE FURSTIONS In this area, methods for restoration of productive immune/inflammation channels should concentrate. WBHT and other temporary fever -triggering therapies can be useful clinical aids not only in the treatment of depression, but also in other chronic inflammatory diseases by contributing to the restoration of this important biological function.

  1. janssen cw, lowry ca, flour mr, et al. All -body hyperthermia for the treatment of serious depressive disorders: a randomized clinical study. Jama Psychiatry . 2016; 73 (8): 789-795.

  2. Hanusch ku, janssen cw. The effects of full-body hyperthermia intervention on mood and depression-are we ready for recommendations for clinical application? intj hyperthermia . 2019; 36 (1): 573-581.

  3. lee ch, giuliani f. the role of inflammation in depression and tiredness. Frontimmunol . 2019; 10 (July): 1696.

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