Study: Effects of DHEA and movement on strength and function in older, frail women
Study: Effects of DHEA and movement on strength and function in older, frail women
The study examines the effects of dehydroepiandrosterone (DHEA) supplementation in combination with movement on muscle strength and physical function in frail older women. 99 women took part in the double-blind, randomized, placebo-controlled study who had low DHEA levels, low bone mass and frailty. The participants received 50 mg/day dhea or placebo either for 6 months and also took 630 mg/day calcium and 400 IE cholecalciferol. All women took part in a training program twice a week. The results showed that the combination of DHEA supplementation and movement improved the muscle strength of the lower extremities and physical performance. However, no significant change in the bone mass was found. The authors of the study come to the conclusion that a DHEA supplementation in combination with gentle movement in frail older women improves muscle function, but has no sole impact on performance. Further studies are required to assess the exact contribution of the DHEA supplementation compared to the advantages of movement alone.
Reference
Kenny am, Boxer RS, Klepinger A, Brindisi J, Feinn R, Burleson yes. In combination with movement, dehydroepiandrosterone improves muscle strength and physical function in frail older women. j bin Geriatr Soc . 2010; 58: 1707-1714.
Design
double -blind, randomized, placebo -controlled study
participant
nine -nine women (average age 76.6 ± 6.0 years) with low sulfated dhea (DHEAS), low bone mass and frailty
Intervention
The participants received 50 mg/day dhea or placebo for 6 months; All received 630 mg/day calcium and 400 ie cholecalciferol. Women took part in a training program for 90 minutes twice a week.
primary result dimensions
Before and after the study, hormone levels, bone mineral density (BMD), bone sales markers, body composition, power of the upper and lower extremities as well as physical performance were measured.
most important knowledge
87 women (88 %) completed 6 months. No significant change in the BMD or bone sales marker was found. Those who received a DHEA supplement together with physical activities recorded growth in the power of the lower extremities and an improvement in the short physical performance battery score, which focuses on the function of the lower extremities). DHEA was associated with significant changes in all hormone levels, including DHEAS, estradiol, estrone and testosterone, as well as a decline in gender -binding globulin levels.
effects on practice
This study again confirms that a DHEA supplementation does not improve the BMD or bone sales markers. The authors come to the conclusion that a DHEA supplementation improves the power and function of the lower extremities in older, frail women, which do gentle exercises, although in reality it cannot be proven that the DHEA supplementation had a significant influence on performance. Other studies have shown no effect from DHEA on training groups. 1 is well documented that physical activity leads to positive improvements in many ways, including the measurement of biophysical markers as well as strength, flexibility and functionality. However, this study does not provide any clear evidence that a DHEA supplementation can lead to performance improvements solely. In this study it was found that a DHEA supplementation in combination with movement in women who were selected due to low DHEAS values improved the muscle strength of the lower extremities, which was reflected in an improvement in the physical performance of the lower extremities.
A DHEA supplementation does not improve the BMD consistently at all points of the skeleton or in the body composition.
A DHEA supplementation does not consistently improve the BMD at all points of the skeleton or in the body composition. 2.3,4 A sole DHEA supplementation over a period of two years had no significant physiological influence on the body composition. -strength. 7.8 In fact, a study has shown that an improvement in strength and physical function only occurred when groups that also took DHEA also completed training with high resistance.
Further studies must be completed in order to assess the actual contribution of the DHEA supplementation to strength and physical performance compared to the known advantages of movement alone.
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