Study: Antiabetic effect of ginseng extract

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Reference Park SH, OH MR, Choi EK, et al. An 8-week, randomized, double-blind, placebo-controlled clinical study on the antidiabetic effect of hydrolyzed ginseng extract. J GINSENG Res. Epub May 26, 2014. Study design randomized, double -blind, placebo -controlled clinical study for patients with limited sober -lens level participants with impaired sober glucose values ​​between 5.6 and 6.9 mmol/l (101–124 mg/dl) and without diagnosis of another disease were selected for participation in the study. One hundred patients were examined for inclusion and 77 were excluded. The exclusion criteria included other abnormal laboratory tests; Cardiovascular, gastrointestinal or kidney diseases; a history of the use of antipsychotic drugs; Taking corticosteroids or lipid -reducing medication; Alcohol ...
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Reference

Park SH, Oh Mr, Choi Ek, et al. An 8-week, randomized, double-blind, placebo-controlled clinical study on the antidiabetic effect of hydrolyzed ginseng extract. J Ginseng res. Epub May 26, 2014.

study design

randomized, double -blind, placebo -controlled clinical study for patients with limited sober glucose level

participant

adults with impaired sober glucose values ​​between 5.6 and 6.9 mmol/L (101–124 mg/dl) and without diagnosis of another disease were selected for participation in the study. One hundred patients were examined for inclusion and 77 were excluded. The exclusion criteria included other abnormal laboratory tests; Cardiovascular, gastrointestinal or kidney diseases; a history of the use of antipsychotic drugs; Taking corticosteroids or lipid -reducing medication; Alcohol or drug abuse; Acute or chronic inflammation; Allergy or hypersensitivity to one of the ingredients of the test products; Pregnancy or breastfeeding. Double-free participants were randomized either a hydrolyzed ginseng extract or placebo. Three participants left for personal reasons, so that 20 people had to end the process.

Intervention

Hydrolyzed ginsensgextract (HGE; ILHWA CO LTD, Guri, South Korea) was used. The ginseng was hydrolyzed by pectinase and contained 7.54 mg/g of the ginsenoside RG1; 1.87 mg/g re; 5.42 mg/g RB1; 0.29 mg/g RC; 0.36 mg/g RB2; and 0.70 mg/g Rd. The content of connection k (another ginsenoside metabolite) in the HGE was 6.3 mg/g. Both the placebo and the ginseng preparation contained pumpkin seed oil, refined palm oil and a yellow wax. It was administered as a capsule (480 mg/capsule 2x/day).

target parameter

The rating parameters included the sober plas maglucose level (FPG) and the postprandial glucose test (ppg; also known as an oral glucose tolerance test). [Ogtt]), sober-plasma insulin (FPI) and postprandial insulin (PPI). The insulin resistance is assessed using the homeostasis model (homeostatic model evaluation). [HOMA] -IR) and beta-stazed sensitivity (Homa β) were also followed. The measurements of the circulating end products of glycosylation were glycated albumin, fructosamine and hemoglobin A1C (HBA1C). Finally, the kinetics of the glucose and insulin changes based on the incremental area under the curve (aauc) and the maximum concentration (c) was evaluated by each.
In this study, FPG, plasmaglukose during PPG/OGTT, glucose iauc and glucose c were evaluated max max

most important knowledge

After the 8-week intervention with 480 mg twice a day, statistically significant differences in the FPG were found ( p = 0.017) and ppg60min ( p = 0.01). PPG30min ( p = 0.059), FPI ( p = 0.063) and PPI60min ( p = 0.077) showed a tendency to improve a somewhat stronger improvement than the placebo group, although the results did not achieve statistical significance.

effects on practice

The health effects that are associated with poor glucose control have increased, in particular the occurrence of non-insulin-dependent diabetes and cardiovascular diseases. According to estimates by the World Health Organization, 347 million people suffer from diabetes worldwide, and by 2030, diabetes will be the most seventh cause of death. 1 While it is important to tackle the many decisive factors that are involved in this insidious disease, researchers continue to look for different types of medication, including plant -based extracts.
While research is still being carried out, which ginsenosides are best suited in which doses, doctors can recommend ginseng without hesitation as an adaptogen and to improve physical endurance, which has been in its traditional role for thousands of years
Panax ginseng may be one of the most famous and best researched vegetable drugs in the world. In China, it has long been used to strengthen Qi and to support the airways and digestive system and is becoming increasingly popular in North America as adaptogen. The latest preclinical examinations have supported the use of ginseng in abnormal metabolic parameters such as glucose intolerance, metabolic syndrome and non-insulin-dependent diabetes mellitus (NIDDM). However, attempts with human interventions are still in the early stages and have mixed results. While this current study has shown a slight improvement in FPG and PPG, the researchers did not provide any information on randomization or blindness, which means that this study cannot be included in a systematic analysis. After 8 weeks, they did not give any specific results on the laboratory results when fasting. Instead, the study is based on a graphic presentation of the standard deviation of the Iauc, and although this becomes standard, it is of the opinion of this author that more details should be included in order to really assess the validity of this study.
A systematic review of red ginseng and NIDDM from 2011 analyzed four randomized clinical studies and showed that there was most likely in at least three of the studies. Many of the smaller studies, such as these, come from Korea, where the majority of the red ginseng is grown and most likely subsidized by the government. Another problem discussed in the 2011 review, which is also available in our example, is the small number of participants.
A special factor that can be important when evaluating the literature and the consideration of whether Ginseng should be used in patients is important. Korean red ginseng has certain parameters for processing: it must be harvested if the root is 6 years old, and correctly steamed or heated to increase the saponing content. According to Chen and Chen in their book Chinese Medical Herbology and Pharmacology, red ginseng is warmer in the unprocessed state and is best used for Qi and Yang deficiency. Wild bred red ginseng is the most expensive resource reserved for severe cases of Qi deficiency.
In this special study, the ginseng was hydrolyzed using pectinase. The composition of the ginsenosides changes due to hydrolysis, so that more active metabolites are created. Ginsenosides were the subject of extensive preclinical research. In vivo studies with the ginsenosids RB2, RG1, RH2 and RE showed an activation of adenosine monophosphate kinase (AMPK), which has been shown to improve insulin sensitivity, reduces glucose production in the liver.
Another option to process ginseng is the fermentation using β-glucosidase-producing microorganisms 6 or the gypenoside path in the human intestine. For example, the ginsenoside Protopanaxadiole RB1, RB2 and RC are converted into connection by deglycosylation reactions of intestinal bacteria. 7.8 It was shown that it suppresses the NF-κB activation 9 and induce autoptosis. 10 (TB1 can also be found in Panax Quinquefolius American ginseng.
There are other secondary factors that can support the use by a doctor Panax-Ginseng . One example is the use in patients who need support in correction of a hypothalamus-hypophysen-nine-native axis that has been made from balance from balance. Another option could be to alleviate inflammation. Another reason is to improve the energy so that the patient can start or increase a training plan. Panax ginseng can be used to tonize a system, and yet it can certainly be used for very specific purposes, such as the stimulation of the AMPK and NF-κB signal paths.
The evidence in this study complement extensive research on this topic Panax-ginseng . While research is still being carried out which ginsenosides are best suited in which doses, doctors ginseng can recommend use that has been in its traditional role for years.
This article was part of the special of August 2014 Journal of Natural Medicine Topic on Endocrinology. To see the rest of the special edition, click (link removed).

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