Cattle colostrum for the prevention and treatment of infectious diarrhea in children
Cattle colostrum for the prevention and treatment of infectious diarrhea in children
reference
Li J, XU YW, Jiang JJ, Song Qk. Cattle colostrum and product intervention in connection with the relief of infectious diarrhea in children. Scientific Rep . 2019; 9 (1): 3093.
Study goal
Assessment of the effectiveness of beef colostrum in the prevention and treatment of infectious diarrhea in childhood
draft
meta analysis of 5 randomized controlled studies (RCTS)
participant
The meta analysis comprised 324 children from 5 RCTs. 97 of the children were healthy infants; 120 children were hospitalized with Rotavirus diarrhea; In 27 inpatient children, diagnosis was diagnosed e coli ; and 80 were outpatient children in which Rotavirus diagnosis was diagnosed.
study parameters evaluated
The researchers searched the literature on beef colostrum and found 5 RCTs that met the inclusion criteria and examined the use of beef colostrum as a therapeutic means of preventing or treating infectious diarrhea in children.
primary result measurements
COUNTRY, PLATION IDED in the stool and number of patients with diarrhea at the end of the study
important knowledge
The pooled results of these studies showed some different results, depending on which result was used. Overall, children with infectious diarrhea reducing the frequency of stool by 1.42 stool ducts per day and a 77%reduction in the pathogens found in the stool. When children used beef colostrum as a preventive agent, the probability that they became symptomatic was significantly lower with a pooled OR.
practice implications
research that expands our instrument against infectious diseases, especially in pediatrics, is always exciting. Since infectious diarrhea causes 2 to 3 million deaths in young children, new treatments are welcome.
First, none of the RCTs used in stores. Everyone had their colostrum created especially for the study. Most were processed into a standardized end product, although 1 study made the colostrum directly without processing. In addition, 4 of the 5 studies used colostrum of hyperimmune cows (cows that were vaccinated against certain tribes by both e coli or rotavirus at the end of pregnancy). This is hardly comparable to the commercial colostrum products to which most of us have access.
Since infectious diarrhea causes 2 to 3 million deaths in young children, new treatments are welcome.
With a lack of standardization in preparation, a lack of standardization in dosage was associated. A study used a total of 10 g colostrum per day; another used 7 g 3 times a day; And another with a dosage of 0.5 g/kg, which would bring a child of 20 lb (9.07 kg) a dose of about 4.5 g a day.
Thirdly, this study summarized data for both prevention and treatment and bundled significant differences in terms of patient type and patient age. While this led to a more robust sample size (n = 324), the non -specificity in relation to timing and populations makes the conclusions less clinically useful.In addition, we have to take ethical and ecological effects into account when using products of animal origin. We would like to be very specific when procuring beef colostrum to ensure that it comes from human and environmentally conscious producers.
Now about the good news: colostrum is considered pretty safe - technically more food than medicinal products. Despite the restrictions of the meta -analysis checked here, colostrum seems to have potential to prevent and treat diarrhea in children. However, the question remains whether products available in the trade lead to favorable results. Further studies are required.
While human studies are still missing, there are some convincing in-vivo and animal experiments that indicate that commercially available colostrum can be helpful when binding to viruses and bacteria, the modulation of immune activity and the reduction of lipopolysaccharide (LPS) damage. Risks and side effects seem to be quite low, curious doctors could be inclined to subject this intervention to a clinical test.
However, we would also be carelessly forgotten our 2 most important treatments to prevent infectious diarrhea in small children: breastfeeding and the redvirus vaccination, both of which are effective in primary prevention.
- Dennehy Ph. Viral gastroenteritis in children. Pediatr Infect Dis J . 2011; 30 (1): 63-4.
- Ulfman LH, Leusen JHW, Savelkoul HfJ, Warner Jo, van Nerven RJJ. Effects of cattle immunogloclobulins on immune function, allergies and infections. front Nutr . 2018; 5: 52.
- Turin CG, Ochoa TJ. The role of maternal breast milk in the prevention of childish diarrhea in developing countries. Curr Trop Med Rep . 2014; 1 (2): 97-105.
- immunization, vaccines and biologicals: rotavirus. World Health Organization. https://www.who.int/immunization/diseases/rotavirus/en/. Last updated in December 2018. Access on January 30, 2020.
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