Natural eggshell membrane improves pain and stiffness after training

reference

RUFF K, Morrison D, Duncan S, Back M, Aydogan C, Theodosakis J. Advantageous effects of the natural eggshell membrane compared to placebo with stress -induced joint pain, stiffness and cartilage turnover in healthy postmenopausal women. clin interv aging . 2018; 13: 285-295. (Link removed)

objective

to determine whether the eggshell membrane (ESM) reduces the stress -induced cartilage turnover, joint pain relieves or relieves joint stiffness.

draft

randomized, double blind, placebo -controlled study

participant

From an initial group of 172 -screen postmenopausal women, 60 women aged 44 to 74 were recorded and randomized either the treatment group (n = 30) or the placebo group (n = 30). The women included in the study had no history of osteoarthritis (OA), rheumatoid arthritis (RA) or other confusing inflammatory joint or connective tissue diseases (e.g. gout, lupus) and were not allowed to use prescription or over-the-counter medication -counter (OTC) pain, joint support supplements and Non -steroidal anti -inflammatory medication (NSAIDS). All participants were assessed as sufficiently healthy by a medical examination to carry out moderate exercises.

Intervention

The treatment group was instructed to take a single 500 mg capsule of Natural Eggshell Membrane (a brand of ESM) every morning before breakfast; The placebo group took a capsule with a similar look, smell and taste according to the same schedule.

The training consisted of 50 to 100 steps per leg on a 6-inch aerobic step on alternating days for 2 consecutive weeks. The number of steps was tailored to the tolerance of every patient who was determined during screening in the clinical center.

study parameters evaluated

The participants were examined in peace on C-terminal networked telopeptide of the type II collages (UCTX-II) in the urine, after 1 week of training and then again after 2 weeks of training.

The change in the stress-induced joint pain or stiffness was assessed daily by a participant questionnaire, with the symptoms being rated on a 10-point scale. The ratings were carried out immediately after training and 12 hours after training, in peace (average from the previous 7 days) and at the start of the study (immediately after the initial training screening).

primary result measurements

The primary endpoint measured for the study was the change in the stress-induced cartilage turnover and degradation, as evaluated by the CTX-II biomarker.

important knowledge

Supplementation with NEM led to a significant response to treatment compared to placebo after 1 week (–17.2 %) and after 2 weeks (–9 %). The pain of recovery (pain 12 hours after training) differed from day 8 to day 14 significantly from placebo, while the immediate pain does not differ significantly. Both the immediate and recreational joint stiffness showed significantly different overall trends compared to placebo; However, these effects were only observed on certain days during the two -week study period. In the treatment group, both the pain of relaxation and the stiffness had almost returned to the resting level by the 14th day, and both were significantly lower than in the placebo group.

practice implications

This special clinical study is based on a handful of previous studies that have proposed mechanisms for the chondroprotective effects of ESM. Previous studies have shown a reduction in cartilage constraints CTX-II in dogs, while other studies have the effects of ESM on the nuclear factor (NF) -CT (NF) and the pro-inflammatory cytokines interleukin (IL) -1β and the tumor necrosis factor (TNF) α, which is an immunomodulatory mechanism of cartilage protection suggested. ^{1-3 An earlier study also found that ESM had a positive effect on pain and stiffness in knee-OA; However, the effects observed in this latest study seem to be the first evidence that indicates benefits in healthy people. In view of the enormous advantages that result from compliance with a consistent training program, therapeutic support for the increased burden on the joint integrity and the associated complaints in the clinical environment in the immediate and short -term time after the training is resumed.}

Despite the statistically significant differences in the CTX II levels compared to placebo in the present study, it is difficult to say whether this result is clinically relevant. CTX-II, a well-known biomarker for cartilage sales, is associated with the appearance and progression of OA and structural damage to RA; In healthy populations, however, it was very variable.

movement is a well -known preventive instrument and a treatment method for the health of joints and cartilage and for almost all other diseases that occur in the clinical environment. ^{9.10 In the event of a long -standing lack of movement, increasing age and reduced functionality, the resumption of training can lead to complaints and pain.}

The advantageous effects of movement on the articular cartilage are known and movement is essential for the preservation of joint health throughout life. However, there is indications that movement can affect the integrity of the articular cartilage - either in the event of excessive loads or in the case of weakened joints. For people who have been settled over a longer period of time, these short -term symptoms can be deterrent enough to get them completely. In view of the enormous advantages that result from compliance with a consistent training program, therapeutic support for the increased stress on the joint integrity and the associated complaints in the clinical environment in the immediate and short -term period after the training is resolved.

In view of the limited duration of study (2 weeks), it is difficult to draw conclusions about the effectiveness of a longer period. As discussed above, exercise can cause short -term symptoms and pain as well as increased articular cartilage when the activity is resumed after long phases of sitting. However, these effects tend to be self -limiting, since cartilage, like other tissues, adapts to the load. 9

In addition, the long -term effects of movement on the articular cartilage, especially in a postmenopausal cohort, are not well understood. The long -term use of a NEM has also not yet been examined, nor did the mechanisms that have been proposed for their advantageous effects on joint pain and stiffness. In view of this, the most useful therapeutic application of a short -term resumption of physical activity in patients who were sedentary over a longer period of time seems to be in the short -term resumption of physical activity. The natural egg shell membrane seems to effectively reduce pain and stiffness in both healthy and OA-affected joints and can therefore show a benefit for both groups. The acceptance of immediate and recovery pain and stiffness during the early phases of the resumption of the training can help improve compliance with a training plan and to reduce the relapse into a state of lack of movement.

If future research is able to continue to validate a clinically relevant role in the direct treatment of CTX II levels, the use of an exciting and potentially very useful can become the treatment and prevention of degenerative and inflammatory joint diseases.