Metformin and diabetic neuropathy: Think of B12

Metformin and diabetic neuropathy: Think of B12
reference
Alvarez M, Sierra Or, Saavedra G, Moreno S. Vitamin B
objective
This study evaluated the prevalence of vitamin B
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In this cross -sectional study, the researchers used a linear regression model to evaluate variables that correlated with vitamin B 12 mirror and the correlation between the changed vitamin B The researchers checked the clinical records of endocrinology patients who visited an endocrinology service from a hospital in Bogota, Colombia in 2017. They identified patients who have been treated with metformin for more than 3 months and identified retrospectively patients with diagnosed diabetes mellitus or prediabetes who have been treated longer than 3 months. The study included a total of 162 patients (72 men and 90 women) and the average age was 64 years. The average daily dose of metformin was 1,536 mg and the average duration of taking metformin was 108 months. researchers have measured vitamin B Overall, little vitamin B vitamin B vitamin B This raises the question of what else could reduce B A survey at PubMed using the mesh terms "Diabetes and Metformin" delivered 95 publications on this topic from 1971. In 1971 Tomkin pointed out that the deficiency in B This low defect prevalence implies that the remaining 93 % of the participants do not close enough to B celiac disease, which the absorption of B In addition, many doctors, including this expert, have observed that non -identified, uncontrolled diabetics can have diabetic peripheral neuropathy. This is the symptom through which some are initially identified. This does not mean that these diabetics may not be a b In the conclusion discussed here, the authors state in their conclusion: "The association between diabetic neuropathy and vitamin b 12 deficiency is of great importance, since diabetic or predicative patients, in whom diabetic neuropathy was diagnosed, can have neuropathy due to vitamin B deficiency." While this appears true, the publication of the idea seems to be dedicated that B This expert is convinced that doctors should assess the entire intestinal absorption in all of our patients, not only from those who receive metformin. Nevertheless, this publication is a timely reminder, on B NOTE: Vitamin B participant
study parameters evaluated
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- Berchtold P., Bolli P., Arbenz U., Keizer G. [Disturbance of Intestinal Absorption Following Metformin Therapy (Observations on the Mode of Action of Biguanides)] [Article in German]. diabetology . 1969; 5 (6): 405-412.
- Tomkin GH, Hadden Dr, Weaver yes, Montgomery there. Vitamin B12 status of patients under Metformin long-term therapy. br med j . 1971; 2 (5763): 685-687.
- Kizilgul, M., Ozcelik, O., Beysel, S., et al. Screening on celiac disease with poorly set diabetes mellitus type 2: is it worth it or not? BMC endocr disord . 2017; 17 (1): 62.