Could quercetin help with polycystic ovarian syndrome (PCOS)?

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Reference N. Rezvan, A. Moini, L. Janani et al. Effects of quercetin on the obesity-mediated insulin sensitivity in polycystic ovarian syndrome: a randomized placebo-controlled double-blind clinical study. Horm Metab Res. 2017; 49: 115-121. Design A 12-week randomized placebo-controlled double-blind clinical study was carried out to determine the effect of quercetin supplementation on serum adiponectin levels in women with polycystic ovarian syndrome (PCOS). Participants with a total of 84 women with PCOS who were diagnosed according to the Rotterdam criteria, between the ages of 20 and 40, with a BMI between 25 and 40 kg/m2 were included in the study. People with accompanying endocrine or metabolic diseases (hypothyroidism, hyperthyroidism, androgen secretive tumors, diabetes mellitus, ...
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reference

n. Rezvan, A. Moini, L. Janani et al. Effects of quercetin on the obesity-mediated insulin sensitivity in polycystic ovarian syndrome: a randomized placebo-controlled double-blind clinical study. horm metab res . 2017; 49: 115-121.

draft

A 12-week randomized placebo-controlled double-blind clinical study was carried out to determine the effect of quercetin supplementation on serum adiponectin levels in women with polycystic ovary syndrome (PCOS).

participant

A total of 84 women with PCOS who were diagnosed according to the Rotterdam criteria, between the ages of 20 and 40, with a BMI between 25 and 40 kg/m 2 were included in the study. People with accompanying endocrine or metabolic diseases (hypothyroidism, hyperthyroidism, androgen secretive tumors, diabetes mellitus, adrenal hyperplasia, cushing syndrome) and people who earn disruptive medication (metformin, contraceptives, antihypertensiva, fatty stabs, inflammation inhibitors) excluded.

Intervention

The participants of the test group (n = 42) received a total of 1 g of quercetin (Jarrow, USA) every day, with a 500 mg capsule being taken orally after breakfast and lunch. The control group (n = 42) followed the same dosage scheme, but with placebo capsules that contained strength. The adherence was monitored every 2 weeks through weekly telephone controls and by counting the number of capsules returned.

target parameter

The primary target parameters were changes to the serum levels of total and high molecular (HMW) oboneectine. In addition, the following anthropometric, metabolic and hormonal measurements were evaluated: weight, BMI, ratio of waist to hip (WHR), serum testosterone, luteinizing hormone (LH), sex hormone-binding globulin (SHBG) and homeostatic model evaluation of insulin resistance (Homa-IR). The reviews were carried out at the beginning of the course and in week 12.

important knowledge

of the 84 registered participants could not complete only 2 participants, both in the control group. One broke the intervention due to reported diarrhea and the other was lost for aftercare.

While the results of this study have informed the role of obelinity in the insulin resistance, it is still unclear whether and how the PCOS symptoms are influenced by increasing values.

In the experimental group, the total and HMW adiponeect insects were significantly higher (8.6 % and 7.4 %; p <0.001 for both) at the end of the study compared to the initial value. Remarkable and significant improvements in Homa-IR (17.5 %; p <0.001), serum testosterone and LH were also observed. Quercetin had a marginal effect on SHBG. Placebo did not bring any therapeutic benefits regarding these measures. Changes in weight, BMI and WHR were not significantly different between the two groups. An inverse correlation between oboneect insect and Homa-IR, BMI and WC was found and considered statistically significant.

practice implications

Insulin resistance and subsequent hyperinsulinemia are common clinical features of PCOS. With an estimated prevalence of 50 % to 70 %, insulin resistance is an essential factor that contributes to the pathophysiology of the disease. 1 An proposed mechanism of PCOS contains the stimulation of the ovaries by insulin, which leads to testosterone production and finally an androgen surplus leads. 1 treatment protocols for PCOS, both conventional and naturopathic, typically include insulin sensitization as the primary goal. At least the reduction in insulin level reduces the risk of type 2 diabetes mellitus and cardiovascular diseases. At most, it can also help control the symptoms.

The gold standard for the diagnosis of insulin resistance is hyperinsulinemic-egglycemic terminals, although it is not used frequently. Instead, diagnosis and management are usually based on the clinical appearance and sober -blood sugar and hemoglobin a 1c 2 In contrast to other obokines, its effects are protecting (anti -inflammatory, antiabetic, antia -diabetical, card conductive) and the mirrors are related to a metabolic dysregulation. 3

The first clinical study on the examination of oboneectin and his role in PCOS-related metabolic syndrome was published in 2003. She identified a direct correlation between the oboneect insect and the glucose abbreuers ( p = 0.043) and an inverse correlation with WHR ( p = 0.024). It also recognized the oboneect insert as a valid indicator of the belly fat.

trolle et al. confirmed the reverse correlation between oboneect insect mirrors and WHR and found that the same applies to insulin and homa-i-IR. Metformin was also tested as part of this study to determine its ability to increase the oboneect insect mirror. 5 No significant changes were observed, and several other work documented the same result. Pioglitazon, 8 Rosiglitazon, 9 and the combination of flutamide plus metformin. 10

In the studies with the medication mentioned above, the researchers also reported significantly lower adiponectin output values ​​in patients with PCOS compared to people without PCOS with the same weight. The results indicate that obesity leads to changes in the values ​​even without obesity. However, depending on the body composition, slim PCOS patients may still have a risk of low oboneectin and insulin resistance.

This study was the first to evaluate the effect of quercetin on PCOS, although previous research showed therapeutic benefits for numerous diseases and emphasize the antioxidant effect of quercetin 11 and anti -inflammatory 12 . A study published in September 2017 showed that women with PCOS suffer more from oxidative stress and inflammation than women without PCOS. It is therefore not surprising that quercetin is currently of interest to researchers. 13 It is also worth noting that PCOS can expose women to a higher risk of ovarian cancer. can. fifteen

While the results of this study have informed the role of oboneectin in insulin resistance, it is still unclear whether and how the PCOS symptoms are influenced by increasing values. Further research to investigate the long -term results of the nutritional supplement is required to better understand your use in the treatment of PCOS. Until then, Quercetin is a low -risk intervention that can serve as an advantageous additional treatment.

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