Coffee in connection with better results in colon cancer

Coffee in connection with better results in colon cancer
reference
hu y, King M, Yuan C, et al. Association between coffee consumption after the diagnosis of colon cancer and reduced mortality. gastroenterology . 2018; 154 (4): 916-926.
draft
prospective observation study
objective
The connection between coffee consumption should be examined after the diagnosis of colon cancer (CRC) and mortality.
participant
Participants (n = 1,599) of the Nurses ’Health Study (1984-2012) and the Professionals Follow-Up Study (1986-2012), in which CRC was diagnosed during the study period.
target parameter
semi -quantitative questionnaires on the frequency of food (SFFQ), which were collected at least 6 months, but no more than 4 years after the diagnosis. The starting point before the diagnosis was estimated from the last SFFQ completed before diagnosis.
important knowledge
During a median after -observation period of 7.8 years there were a total of 803 deaths, including 188 due to CRC. Participants who consumed at least 4 cups of coffee a day had a 52 % lower risk of CRC-specific death compared to non-drinkers (Hazard Ratio [HR]: 0.48; 95 % confidence interval [CI]: 0.28-0.83; p for trend = 0.003). Those who consumed more than 4 cups a day also had a 30 % reduced risk of deaths of any cause (HR: 0.70; 95 % KI: 0.54–0.91; p for trend <0.001). When assessing coffee consumption before and after the diagnosis, those who consumed more than 2 cups per day before and after the diagnosis had a 37 % reduced risk of CRC-specific death (HR: 0.63; 95 % KI: 0.44-0.89) and a 29 % reduced risk of death (Mr.: 0.71; 95 % AI: 0.60-0.85) compared to those who consistently drank less than 2 cups every day.
practice implications
In this study, the consumption of coffee after the diagnosis of CRC was associated with a lower risk of CRC-specific mortality and overall mortality.
Remarkably, both caffeinated and decaffeinated coffee were associated with improved results. This is in contrast to another recently carried out study with CRC patients in stage III, which resulted in a significantly reduced risk of CRC-related deaths and overall deaths with exclusively consumption of coffin (> 4 cups/day). 1 Studies with breast cancer have also found relationships between decaffeinated coffee and less cancer incidence or recurrence. 2.3 Some of the other compounds that may be responsible for the obvious advantages of coffee include phenolic compounds (e.g. chlorogenic acids), lipid (Kahweol, cafestol), polysaccharide) (e.g. Galactomannane, acemannane), phytoestrogens (e.g. trigonnellin) and countless other secondary plant substances that directly influence the characteristic license plates of cancer.
If we look back and evaluate how coffee as food can influence the gastrointestinal function as a whole, its effects on the intestinal microbiota and the intestinalotility possible mechanisms. 5 In addition, it was found that coffee improves the glucose control, and its physiological net parts with metabolic syndrome or fatty Mechanisms proposed.
As with all observation studies, associations can be a replacement for other behaviors that lead to benefits. The choice of lifestyle seems to be particularly demonstrably influenced by the results of the survivors of colon cancer. 6 On this basis, there are many confusing alternatives to lifestyle that are plausible for this study. Perhaps those who drink more coffee do this instead of a sugar -containing drink. Perhaps people who are very fearful will by nature to drink less coffee. Maybe those who don't drink coffee tend to sleep too bad. Perhaps coffee drinkers move more or are at least less sedentary than non -drinkers. These surrogates can be combined as an excess energy weight weight, circadian disorders and higher concentrations of endogenous catecholamines that can affect all of the results. Certainly we will not know whether the coffee itself will benefit until there are intervention studies with randomized participants. Nevertheless, the observation of a dose-effect relationship, in which a higher recording correlates with better results, gives the hypothesis that coffee itself offers protection against CRC and its recurrence. Most of them can be attributed to a lower cardiovascular risk.
coffee is not only associated with a lower recurrence of CRC, but also with a lower incidence of different types of cancer, which means that it contains components with cancer -inhibiting effect. The most consistent is the evidence for the association of coffee consumption with lower first diagnosis of colon, cervix and liver cancer. 10-13 since metabolomics is used to decipher the role of genetic and microbiota influences on the metabolism of its components win from coffee. In the meantime, it is clear from a clinical point of view that coffee consumption does not have to be stopped as part of cancer prevention. When a patient enjoys coffee, it is important that we honor this ritual and let him know that the data is on his side. For some patients, the guilt -free involvement of what they thought was a truck can already be therapeutic.
- Guercio BJ, Sato K, Niedzwiecki D, et al. Coffee consumption, recurrence and mortality in colon cancer in stage III: Results from CalGB 89803 (Alliance). j clin oncol . 2015; 33 (31): 3598-3607.
- Lowcock EC, Cotterchio M, Anderson LN, Boucher BA, EL-SOHEMY A. High coffee consumption, but no caffeine, is associated with a reduced estrogen receptor-negative and postmenopausal risk of breast cancer without effect modification by CYP1A2 genotype. Nutr cancer . 2013; 65 (3): 398-409.
- Bøhn SK, Blomhoff R, PAUR I. Coffee and cancer risk, epidemiological evidence and molecular mechanisms. mol nutr food res . 2014; 58 (5): 915-930.
- gaascht f, dicato m, diederich M. Coffee offers a natural multitarget medicine book against the license plates of cancer. gene Nutr . 2015; 10 (6): 51.
- VitAglione P, Fogliano V, Pellegrini N. Coffee, colon function and colon cancer. food function . 2012; 3 (9): 916.
- van Zutphen M, Kampman e, Giovannucci el, van duijnhoven fjb. Lifestyle after the diagnosis of colon cancer in relation to survival and recurrence: an overview of the literature. Curr colon cancer rep . 2017; 13 (5): 370-401. DOI: 10.1007/S11888-017-0386-1.
- Schmit SL, Rennert HS, Rennert G, Gruber SB. Coffee consumption and colon cancer risk. biomarker for crab epidemics PREV . 2016; 25 (4): 634-639.
- thing M, Satija A, Bhupathiraju Sn, et al. Association of coffee consumption with the overall mortality and the cause -specific mortality in 3 large prospective cohorts. Clinical perspective. traffic . 2015; 132 (24): 2305-2315. DOI: 10.1161/Circulationaha.115.017341.
- Zhao Y, Wu K, Zheng J, Zuo R, Li D. Association of coffee with total mortality: a systematic review and meta -analysis. public health nutr . 2015; 18 (7): 1282-1291. Doi: 10.1017/S1368980014001438.
- sang LX, Chang B, Li XH, Jiang M. Coffee consumption in connection with a reduced risk of liver cancer: a meta -analysis. BMC Gastroenterol . 2013; 13 (1): 34.
- Sinha R, Cross AJ, Daniel Cr, et al. Caffeine-containing and decaffeinated coffee and tea consumption and the colon cancer risk in a large prospective study. am j clin nutr . 2012; 96 (2): 374-381.
- je y, Giovannucci E. Coffee consumption and risk of endometrial carcinoma: results of a large current meta -analysis. intj cancer . 2012; 131 (7): 1700-1710.
- Arab L. Epidemiological evidence of coffee and cancer. Nutr cancer . 2010; 62 (3): 271-283.
- Guertin Ka, Loftfield e, Boca Sm, et al. Serum biomarkers of habitual coffee consumption can give an insight into the mechanism, which is based on the connection between coffee consumption and colon cancer. am j clin nutr . 2015; 101 (5): 1000-1011.