The effect of the mixture of mulberry leaf and extract made of white kidney beans on postprandial glucose control in predicament patients
The effect of the mixture of mulberry leaf and extract made of white kidney beans on postprandial glucose control in predicament patients
reference
Liu Y., Zhang J., Guo H., et al. Effects of a mixture of mulberry leaves and extract from white kidney beans on postprandial glycemic control in predicative persons aged 45-65 years: a randomized controlled study. j funct foods . 2020; 73: 104117.
Study goal
The acute and chronic effects of 2 plants - mulberry leaf and white kidney bean - with different antihyperglycemic components on glucose control in patients with prediabetes should be determined
draft
A randomized, simply blinded control study at the Department of Nutrition and Food Hygiene, School of Public Health, in Beijing
participant
The study comprised 66 participants aged 45 to 65, all with prediabetes. One person was excluded because they could not participate in part of the study. The researchers recruited participants via flyers, posters and the Internet and selected them during a period of one month between July and August 2018.
The researchers examined the participants based on 2 methods of criteria: a questionnaire and laboratory tests.
The researchers took over the prediabetes diagnosis criteria of American Diabetes Association (ADA): Glycohemoglobin (i.e. hemoglobin a
subjects were excluded if they had one of the 5 following criteria:
- existing diagnosis of a disease that could influence the glucose metabolism. This included diabetes, digestive disorders, thyroid problems, kidney diseases, liver diseases or cancer
- Long -term use of nutritional supplements or drugs that influence the glucose metabolism
- Allergic reactions to study products
- inability to participate in the interview due to problems in connection with visual, hearing or intellectual disabilities
- pregnancy or breastfeeding
study parameters evaluated
The researchers carried out the laboratory tests 2 weeks before the start of the study, including tests to sober blood sugar and hemoglobin a
The participants were divided into 2 groups with 33 participants, one acted as a control group and the other as an intervention group.
The researchers used 3 levels to evaluate the acute and chronic effects of the mixture of mulberry leaf and extract from white kidney beans on the glucose control after eating.
level 1 (baseline)
level 1 is the basic line for the study. The researchers took a sober venous blood sample and asked the participants to eat 100 grams of white bread and drink 200 ml of water within 10 minutes. Blood was removed 30, 60 and 120 minutes after consumption.
level 2 (acute effect test)
A week after the basic bleeding, both the test group and the control group again consumed 100 grams of white bread and 200 ml of water within 10 minutes. With this test meal, the test group also received a mixture of mulberry leaf and white kidney bean extract (1.5 grams). The control group received nothing. Again, blood was removed 30, 60 and 120 minutes after consumption.
level 3 (chronic effects test)
According to level 2, the test group consumed 1.5 grams of mulberry leaves and extract from white kidney beans every meal, 3 times a day with its normal diet over a period of 4 weeks. Therefore, the participants of the test group received a total of 4.5 grams of the dietary supplement every day. The control group received no nutritional supplement and also took its normal nutrition.
The researchers contacted the participants three times a week to help them comply with the protocols for the study. Twice during phase 3 (on day 15 and day 29), the participants received a meal with 100 grams of white bread and 200 ml clear water, which they should eat in 10 minutes, and their blood sugar levels were 30, 60 and 120 minutes later checked to eat.
It is assumed that the common use of both substances has greater potential to reduce the postprandial glucose mirror by combining active antiglycemic active ingredients in every plant.
The participants were asked during the entire study to avoid mulberry leaves, white kidney beans and all substances that contained mulberry leaves or white kidney beans, as well as avoid everything that could change their glucose metabolism. The participants were asked to maintain their normal movement and eating habits.
Two days before each visit to take a blood, the participants received instructions to avoid strenuous exercises, severe meals, caffeine, alcohol and tobacco; to consume the same meal each time before they went to take blood; And fast 10 to 14 hours before they came in. They were asked to come in on the morning of blood acceptance before 9:00 a.m. and received instructions on the examination process.
primary result measurements
level 2 (acute effects)
- The postprandial glucose levels were lowered after 30 minutes compared to the starting value ( p <0.001) and after 60 minutes ( p = 0.006).
- The postprandial insulin levels were humiliated after 30 minutes compared to the starting value ( p = 0.002) and after 60 minutes ( p = 0.010).
- The postprandial C-peptide levels were humiliated after 30 minutes compared to the starting value ( p = 0.010) and after 60 minutes ( p = 0.002).
The last measurement looked at the area under the curve, which was 120 minutes after taking the mixture of mulberry leaves and extract from white kidney beans, and showed significant decreases from the baseline for glucose, insulin and c-peptide.
level 3 (chronic effects)
The nutritional supplement with a mixture of mulberry leaves and extract made of white kidney beans did not lead to significant changes, measured by the area under the curve (120 minutes) for the glucose, insulin or C peptide levels on the days 15 and 29.
The homeostatic model evaluation-insulin resistance (Homa-IR), the hemoglobin a
important knowledge
for phase 1, the basic phase of the study, there was no significant difference between the test group and the control group, even after adjusting the body mass index (BMI).
In the acute phase of the study, however, the test group had significantly lower postprandial glucose, postprandial insulin and postprandial C peptide values in the 30-minute and 60-minute periods. These measures were also lower after they were adjusted for the BMI. In the 120-minute time frame, the percentage change in the intervention group for postprandial glucose, postprandial insulin and postprandial C-peptide was significant (compared to the initial value) than in the 30- and 60-minute time frame.In the chronic phase of the study, the test group showed no significant effects.
practice implications
This is the first study that examined the combination of mulberry leaves and extract from white kidney beans to reduce the glucose mirror.
It is assumed that the common use of both substances has greater potential to reduce the postprandial glucose mirror by combining active antiglycemic active ingredients in every plant. White kidney beans contain an active α-amylase inhibitor, and the 1-desoxynojirimycin (DNJ) contained in mulberry leaves also blocks α-amylase activity. The flavonoids and polysaccharides in the mixed extract also show alpha-glucosidase-inhibiting activities.
alpha-amylase and α-glucosidase are two burst room enzymes that are responsible for the starch metabolism in the proximal small intestine. By blocking enzymes that reduce carbohydrates, the carbohydrates remain intact and are too great to be absorbed. This has an impact on predicative and diabetic population groups, since a lower absorption is a key factor for the reduction of blood sugar levels and can influence the HBA value in the long term 1c 1
Adding food with a high content of α-amylase inhibitors can be indicated for predicative patients in order to include them in their nutritional plans in order to reduce postprandial glucose levels. Alpha-Amylase inhibitors are contained in addition to white kidney beans in many garden beans, especially in red kidney beans and black kidney beans. 2 The consumption of food that restrict the digestion and absorption of strength can be a good means to modify the blood sugar level, and further research should give us better instructions Get to know the best food combinations to control the glucose mirror.
- Lee BH, Eskandari R., Jones K., et al. Modulation of the starch digestion for a slow glucose friction by "switching" the activities of mucosal α-glucosidases. jbiolchem . 2014; 287 (38): 31929-31938.
- Caballero B, Finglas PM, Tolddrá f, ed. encyclopedia of nutrition and health . Waltham, MA: Academic press; 2016.