Adding L-Citrullin increases the plasma-L arginine in men

Adding L-Citrullin increases the plasma-L arginine in men
reference
Suzuki t, Morita M, Hayashi T, Kamimura A. The effects of a combined oral L-Citrullin and L arginine supplementation in healthy men on the plasma-L arginine level. Biosci Biotechnol Biochem . 2017; 81 (2): 372-375.
draft
double-blind, randomized, placebo-controlled study
participant
42 Healthy, non-weighted Japanese men aged 20-49; Smokers and men who took medication or nutritional supplements were excluded. The men were randomized in 1 of 4 groups:
- placebo (corn starch) (n = 11)
- l-citrullin alone 2.0 g/day (n = 11)
- L-arginine alone 2.0 g/day (n = 10)
- l-citrullin with L-arginine, each 1.0 g/day (n = 10)
Primary result measurement
Plasma level from L-Arginine after supplementation
important knowledge
One hour after supplementation, all groups showed an increase in L-arginine plasmaspiegel compared to placebo; However, the values in the combination group L-Citrullin, L-arginine were significantly higher (placebo 5.4 ± 16.3; combination 121.9 ± 46.7; Citrullin alone 66.3 ± 33.6; arginine alone 72.3 ± 31.5). The values in the combination group were about 40 % higher than in the group with L-arginine alone. None of the participants had side effects one of the treatments during the study.
practice implications
While previous animal studies have shown that the combination of L-arginine with L-Citrullin increases the L-arginine plasma levels, this is the first clinical study on humans to show this effect. L-arginine supplementation shows in men. Clinical studies in humans have shown that L-arginine supplementation can contribute to improving the erectile dysfunction (ED). 3 Insulin resistance,
Specific for ED shows research that men with ED have low serum levels from L-Citrullin and L-arginine. 6 A reduced nitrogen oxide concentration is associated with an increased risk of erectile dysfunction. Arginine is a nitrogen oxide predecessor, so it makes sense that low concentrations of nitrogen oxide synthase substrates such as L-Arginine and L-Citrullin that could have a positive impact on ED.
This is clinically significant in view of research, which shows the diverse and important health benefits of L-arginine supplementation in men.
There is also indications that complementary L-arginine can contribute to the prevention and treatment of cardiovascular diseases, which is probably due to its influence on the endothelial nitrogen oxide production. From 2016, the clinical benefits of L-arginine supplementation showed especially in ischemic heart disease and once again cited the synthesis of nitrogen oxide production as a key mechanism of the effect.
Due to previous in-vitro and in-vivo research, which show that L-Citrullin suppresses arginase activity,
Since we know that L-arginine can have a positive impact on a man's health, it makes sense to examine this combination from a clinical point of view because it seems to improve the bioavailability of an oral L-arginine supplement. Since it was a small study, further investigations are required to further confirm this effect.
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