Adding L-Citrullin increases the plasma-L arginine in men

Bezug Suzuki T, Morita M, Hayashi T, Kamimura A. Die Auswirkungen einer kombinierten oralen L-Citrullin- und L-Arginin-Supplementierung bei gesunden Männern auf die Plasma-L-Arginin-Spiegel. Biosci Biotechnol Biochem. 2017;81(2):372-375. Entwurf Doppelblinde, randomisierte, Placebo-kontrollierte Studie Teilnehmer 42 gesunde, nicht übergewichtige japanische Männer im Alter von 20-49; Raucher und Männer, die Medikamente oder Nahrungsergänzungsmittel einnahmen, wurden ausgeschlossen. Die Männer wurden in 1 von 4 Gruppen randomisiert: Placebo (Maisstärke) (n = 11) L-Citrullin allein 2,0 g/Tag (n = 11) L-Arginin allein 2,0 g/Tag (n = 10) L-Citrullin mit L-Arginin, jeweils 1,0 g/Tag (n = 10) Primäre Ergebnismessung Plasmaspiegel von L-Arginin nach Supplementierung Wichtige Erkenntnisse Eine …
Relation Suzuki t, Morita M, Hayashi T, Kamimura A. The effects of a combined oral L-citrulline and L arginine supplementation in healthy men on the plasma-L arginine mirror. Biosci Biotechnol Biochem. 2017; 81 (2): 372-375. Design double-blind, randomized, placebo-controlled study participant 42 healthy, non-weighted Japanese men aged 20-49; Smokers and men who took medication or nutritional supplements were excluded. The men were randomized in 1 out of 4 groups: placebo (corn starch) (n = 11) L-citrullin 2.0 g/day alone (n = 11) L-arginine 2.0 g/day alone (n = 10) L-citrulline with L-arginine, each 1.0 g/day (n = 10) Primary results measurement of L-arginine after supplement important knowledge One … (Symbolbild/natur.wiki)

Adding L-Citrullin increases the plasma-L arginine in men

reference

Suzuki t, Morita M, Hayashi T, Kamimura A. The effects of a combined oral L-Citrullin and L arginine supplementation in healthy men on the plasma-L arginine level. Biosci Biotechnol Biochem . 2017; 81 (2): 372-375.

draft

double-blind, randomized, placebo-controlled study

participant

42 Healthy, non-weighted Japanese men aged 20-49; Smokers and men who took medication or nutritional supplements were excluded. The men were randomized in 1 of 4 groups:

  1. placebo (corn starch) (n = 11)
  2. l-citrullin alone 2.0 g/day (n = 11)
  3. L-arginine alone 2.0 g/day (n = 10)
  4. l-citrullin with L-arginine, each 1.0 g/day (n = 10)
  5. Primary result measurement

    Plasma level from L-Arginine after supplementation

    important knowledge

    One hour after supplementation, all groups showed an increase in L-arginine plasmaspiegel compared to placebo; However, the values ​​in the combination group L-Citrullin, L-arginine were significantly higher (placebo 5.4 ± 16.3; combination 121.9 ± 46.7; Citrullin alone 66.3 ± 33.6; arginine alone 72.3 ± 31.5). The values ​​in the combination group were about 40 % higher than in the group with L-arginine alone. None of the participants had side effects one of the treatments during the study.

    practice implications

    While previous animal studies have shown that the combination of L-arginine with L-Citrullin increases the L-arginine plasma levels, this is the first clinical study on humans to show this effect. L-arginine supplementation shows in men. Clinical studies in humans have shown that L-arginine supplementation can contribute to improving the erectile dysfunction (ED). 3 Insulin resistance, 4 and sporty performance. 5

    Specific for ED shows research that men with ED have low serum levels from L-Citrullin and L-arginine. 6 A reduced nitrogen oxide concentration is associated with an increased risk of erectile dysfunction. Arginine is a nitrogen oxide predecessor, so it makes sense that low concentrations of nitrogen oxide synthase substrates such as L-Arginine and L-Citrullin that could have a positive impact on ED.

    This is clinically significant in view of research, which shows the diverse and important health benefits of L-arginine supplementation in men.

    There is also indications that complementary L-arginine can contribute to the prevention and treatment of cardiovascular diseases, which is probably due to its influence on the endothelial nitrogen oxide production. From 2016, the clinical benefits of L-arginine supplementation showed especially in ischemic heart disease and once again cited the synthesis of nitrogen oxide production as a key mechanism of the effect.

    Due to previous in-vitro and in-vivo research, which show that L-Citrullin suppresses arginase activity, 10 The researchers of this present study speculate that this could be a possible mechanism that explains the significant increase with the combination of the 2 amino acids. Earlier investigations have shown that oral L-arginine has a reduced bioavailability, since arginase in the gastrointestinal tract (40 %) and in the liver (15 %) during the first round. By inhibiting arginase activity through the addition of L-citrulline, it is likely that more L-arginine can get through the intestine and the liver into the bloodstream. As was shown in this study and previous studies, L-Citrullin is a forerunner of L-arginine and can only increase the L-arginine level.

    Since we know that L-arginine can have a positive impact on a man's health, it makes sense to examine this combination from a clinical point of view because it seems to improve the bioavailability of an oral L-arginine supplement. Since it was a small study, further investigations are required to further confirm this effect.

  1. Hayashi t, Juliet Pa, Matsui-Hirai H, et al. An L-Citrullin and L-arginine supplementation delays the progression of the atherosclerosis caused by a cholesterol-rich diet in rabbits. Proc NATL ACAD SCI USA . 2005; 102 (38): 13681-13686.
  2. Morita M., Hayashi T., Ochiai M. et al. The oral supplementation with a combination of L-citrullin and L-arginine quickly increases the plasma-L arginine concentration and improves the bioavailability of NO. Biochem Biophys Res Commun . 2014; 454 (1): 53-57.
  3. Chen J, Wollman Y, Chernichovsky T, Iaina A, Sofer M, Matzkin H. Effect of oral administration of high-dose nitrogen oxide-Donator L-arginine in men with organic erectile dysfunction: Results of a double-blind, randomized placebo-controlled course. bju int . 1999; 83 (3): 269-273.
  4. Bogdanski P, Suliburska J, Grabanska K, Joblecka A. Effect of a 3-month L-arginine supplementation on insulin resistance and activity of the tumor necrosis factor in patients with visceral obesity. EUR. Rev. med. Pharmacol. Sci . 2012; 16: 816-823.
  5. Koppo K, Taes Ye, Pottier A, Boone J, Bouckaert T, Derave W. Dietary supplement with arginine accelerates the pulmonary VO2 kinetics during bicycle training. Med Sci Sport Exerc . 2009; 41 (8): 1626-1632.
  6. Barassi a, Corsi Romanelli mm, Pezzilli r, et al. Mirror of L-Arginine and L-Citrullin in patients with erectile dysfunction of different etiology. Andrology . 2017; 5 (2): 256-261.
  7. tousoulis D, Antoniades C, Tentolouris C, et al. L-arginine for cardiovascular diseases: dream or reality. vasc med . 2002; 7 (3): 203-211.
  8. Bahadoran Z, Mirmiran P, Tahmasebinejad Z, Azi F. Food intake of L-arginine and the occurrence of coronary heart disease: lipid and glucose study in Tehran. Nutr Metabol . 2016; 13: 23.
  9. alyavi al, Alyavi Ba, Sayfiyev Ny, et al. Clinical benefits of metabolic therapy of ischemic heart disease with L-arginine supplementation. Saudi J. Med. Pharm. Sci . 2016; 2 (9): 247-249.
  10. Romero MJ, Platt DH, Tawfik He, et al. Diabetes-induced coronary vascular dysfunction included arginase activity. Circ res . 2008; 102 (1): 95-102.
  11. Wu G. amino acid catabolism of the intestinal mucosa. j Nutr . 1998; 128 (8): 1249-1252.
  12. O’Sullivan D, Brosnan Jt, Brosnan Me. Hepatic zoning of Katabolism by arginine and ornithin in the perfunded rat liver. biochemistry j . 1998; 330 (part 2): 627-632.
  13. Schwedhelm e, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: effects on nitrogen oxide metabolism. br j clin pharmacol . 2008; 65 (1): 51-59.