Aloe polysaccharide and propolis as a potential chemopeperminant in smokers

The increased excretion of carcinogenic can be chemofeating by limiting the interaction of electrophilic carcinogenic with biomolecules.

The blood levels of creatinine, glucose and overall bilder bilder were solely (15.24%, 40.22%or 48.82%), propolis (16.83%, 36.25%or 52.59%) and the mixture of reduces aloe polysaccharide and propolis (16.36%, 46.37% 39.20 %;

practice implications

tobacco products cause numerous types of cancer as well as cardiovascular, respiratory and various inflammatory diseases. According to the World Health Organization, around 8 million people worldwide die from the consequences of tobacco consumption every year; More than 7 million deaths are the result of direct tobacco consumption and 1.2 million are due to passive smoking. ^{1 In the United States, cigarette smoking is the main cause of avoidable diseases and deaths. Despite the declining smoking trend, more than 34 million American adults continue to smoke, more than 16 million live with a smoke -related illness and around 480,000 die every year from the consequences of tobacco consumption.}

A current concern of worrying is the rapid increase in the use of electronic cigarettes or e-cigarettes. Some people who used to have normal cigarettes now switch to e-cigarettes because they think they are a safer alternative. 3 Another worrying development is the use of e-cigarettes by young people; They are the most frequently used tobacco product among middle-class students. A CDC press release dated September 6, 2019, 6 stated that serious lung diseases were associated with e-cigarette products. While it is unclear which chemical components do the greatest damage, users are affected by both THC and nicotine-containing products.

Health service providers have the unique opportunity to educate patients about smoking cessation and offer them aids that help them quit smoking. A short and effective intervention can take less than 10 minutes. An easy way to do this is to use the 5 AS:

• ask about use
• Reading
• Evidence of experiments
• help you quit
• agree a aftercare

Even in patients who are not yet willing to quit smoking, it has been shown that the simple conversation with a doctor about smoking habits increases motivation and increases the likelihood of future smoking cessation.

In motivational advice, the 5-R strategy can be helpful:

• relevance (make it personally relevant for the patient)
• Risks (acute, chronic and environmental impact)
• rewards (e.g. improved health, improved appearance and saved money)
• roadblocks (withdrawal, cravings and resources)
• repetition (repeat every time in unmotivated patients; most people companies more than try to stop).

Given the current epidemic of tobacco consumption and its effects on global health, research, as described in this article, is contemporary to circumvent the harmful effects of tobacco products. In this study, aloe polysaccharide and propolis extracts limited, both individually and in combination, exposure to carcinogenic by increasing their excretion through the urine. Tobacco smoke contains at least 70 human carcinogenic. BAP, one of the first identified carcinogenic, was most effective about the urine of people who had received aloe polysaccharide either alone or in combination with propolis extract.

In this study, Cotinin's excretion was also measured, a main metabolite of nicotine and a marker of choice for monitoring the inhalation of tobacco smoke. Cotinin's excretion was also improved by aloe and propolis products. Aloe polysaccharide extract alone was more effective than propolis extract alone, and the combination of the two extracts had a similar effect to that of aloe polysaccharides alone. The authors of this study suggest that the increased excretion of carcinogenic chemofeats could be by limiting the interaction of electrophilic carcinogenic with biomolecules.

aloe vera has long been used as a folk remedy for the topical treatment of wounds and burns. It was also suspected that it has antimicrobial, anti -diabetic, antioxidant and analgesic effects. It was used in patients with skin diseases, arthritis and stomach ulcers. Anthrachinon glycosides (e.g. emodin) are obtained from latex and have a laxative effect. Aloe-polysaccharides are the main components of the inner leaf gel of the aloe and have been shown to have chemofeating and immune-modulating effects. ^{10 aloe polysaccharide extract was used in this study.}

propolis is a natural resin mixture made by honey bees made of substances that are collected by plant parts, buds and exudates. It is known that it has antibacterial, antifungal, antioxidative and anti -inflammatory activities, ^{11 as well as antiabetical and hepatoprotic activity. 12 In this study, the preparation from water -soluble powder was made by freezing ethanol extract.}

In addition to improving the excretion of the BAP and Cotinin, aloe polysaccharide and propolis also reduced the blood levels of creatinine, glucose and overall picture, which is associated with protective effects on the kidneys and the liver as well as with anti-diabetic activity.

Both aloe polysaccharides and propolis have excellent security balance and could be useful as potential chemofeating means in patients who are currently smokers or try to stop smoking.