Can Berberin help diabetes?
Can Berberin help diabetes?
Berber is a natural alkaloid. It contains a large number of traditional medicinal herbs such as turmeric, yellow root, gold thread and Berberitz
It comes from India and China, where it was used for the first time in Ayurvedic and Chinese medical treatments.
An alkaloid is a class of organic connections of plant origin. The Berberinalkaloid mainly contains nitrogen atoms. These have pronounced physiological effects on humans, especially with regard to metabolic and cardiovascular health.
Two herbs, Coptidi's rhizoma and phellodendri Chinensis Cortex, in which Berber is the main active ingredient, have been used in traditional Chinese Medicine for the treatment of diabetes, bacterial gastroentitis, diarrhea and other digestive diseases for hundreds of years.
Many claims about Berber's effectiveness were set up as a remedy for a variety of diseases. But how many of them are evidence -based and how many are wishful thinking?
There is good indications that Berber has antibacterial, antimicrobial, anti -inflammatory and tumor -inhibiting properties and can reduce blood sugar and blood pressure.
Other claims are less well supported by evidence ... claims that the growth of cancer inhibits is advantageous in the treatment of osteoporosis, digestive problems, burns and bacterial infections relieve, etc.
Further research is urgently required.
proven health benefits of Berberin
Berberin offers health benefits for various diseases that are supported by good clinical research. The first will be of interest to people with diabetes and metabolic syndrome.
Berber helps diabetics
A study published in the US National Institute of Health in August 1981 showed that Berberin contributes to reducing blood sugar.
Another study published in February 2019 showed that Berberin has positive effects on glucose lipid metabolism, inflammatory factors and insulin resistance in patients with metabolic syndrome.
The wire strip was another study published by the Metabolism magazine in May 2008 and which compared Berberin with the taking of metformin over three months. The researchers found that Berberin was able to control the blood sugar and lipid metabolism in type 2 diabetics as effectively as Metformin.
Another study published in March 2012 in the magazine Evidence-Based Complementary and Alternative Medicine showed that Berberin can improve insulin sensitivity by storing fat in patients with metabolic syndrome. This implies that Berber may help prevent kidney damage.
Effects of Berber on cholesterol and blood pressure
There are good indications that Berber can help reduce high LDL, total cholesterol and blood pressure values.
The same study mentioned above about Berberin and Glucose Controls, which was published in May 2008 in the Metabolism magazine, showed that Berber will reduce cholesterol and triglyceride levels in serum for type 2 diabetics.
Another study that the administration of red yeast ice cream (which is known to reduce cholesterol) with Berber and published in 2015 in alternative therapy in Health and Medicine showed that Berberin offers a broader spectrum of cholesterol protection with a reduced risk of serious illnesses compared to statin (the prescription medication that is normally used to check the cholesterol).
An animal study published in August 2015 in the Journal of Translational Medicine with the title Effect of Berber on the promotion of cholesterol excretion when hyperlipidemic hamsters induced by fat -rich nutrition showed that Berber can reduce unusually high concentrations of fats and lipids in the blood by excreting cholesterol from the liver and inhibition of absorption from Cholesterol in the intestine.
Studies have also shown that Berber can improve blood pressure and blood circulation in people with metabolic syndrome if it is taken with a healthy diet with a high content of antioxidants or nutritional supplements such as folic acid, coenzyme Q10 and astaxanthin.
Berber supports heart health
Berber has a positive effect on heart health. This is probably due to its ability to keep blood sugar levels and obesity under control, which reduces the risk of coronary heart disease.
It also protects against arteriosclerosis because it stimulates the release of nitrogen oxide, a signal molecule that relaxes the arteries, lowers blood pressure and increases blood flow.
A study published in April 2010 in the World Journal of Cardiology reported that people who took Berber, had a better heart function and were able to exercise better than people who were given a placebo.
Berberin helps with losing weight
Berberin can have a moderate effect on weight loss.
ampk (adenosine monophosphate-activated protein kinase) is an enzyme in human cells that plays a crucial role in regulating the metabolism. Therefore, it is often referred to as the "metabolic main switch".
Berber is one of the few connections that AMPK can activate. Activation promotes fat burning in mitochondria ... This is the reason why several studies have shown that Berberin can prevent the accumulation of fat and protect against the metabolic syndrome.
In such a study published in Phytomedicine in July 2012, obese adults received 500 mg of Berber oral for 12 weeks. This study showed that Berberin is a strong lipid -lowering connection and has a moderate effect on weight loss.
Berberine can help with the administration of Sibo
People suffering from Sibo (overgrown by small intestine bacteria) have excessive bacteria in the small intestine. The disease is usually treated with oral antibiotics, but not always successful.
A study published in Global Advances in Health and Medicine in May 2014 showed that herbal treatment with Berber in the treatment of Sibo looks just as good as antibiotics and is equally safe.
Possible advantages of Berberin
The potential advantages of Berber refer to advantages, for which there are some clinical evidence, which, however, either not strong enough or in any other way in order to prove a certain benefit.
Here are some of these advantages:
cognitive decline ... Studies on people suggest that Berber has a potential therapeutic value against neurodegenerative diseases such as Alzheimer's and Parkinson's and against neurodegenerative diseases based on trauma. Animal studies suggest that it can also help combat depression.
Anti-cancer effects ... Berber can help induce apoptosis, the programmed death of cancer cells. Studies at China Medical University have shown that Berber can induce apoptosis in human tongue cancer cells. Research on how Berberinhydrochloride can regulate the metabolism of cancer cells and their growth and proliferation can continue.
Protection of the liver ... Early research suggests that Berber supports the liver by reducing blood sugar, insulin resistance and triglycerides that are markers for liver damage in people with diabetes and viruses such as hepatitis. It also offers support for people with fatty liver diseases. Research is underway.
lung health ... Studies suggest that Berber's anti -inflammatory effects promote lung function. Mice received Berber in an experiment and were then exposed to enough cigarette smoke to cause an acute lung injury. It was found that the mice to which the alkaloid was administered had fewer inflammation and fewer lung injuries than mice that were exposed to the same amount of smoke, but no Berber received.
How to use Berber
You should be able to find Berber as a dietary supplement in the form of Berberin-HCL in your local health food store. If not, you can order it online.
A natural naturopath can help you determine the most suitable dose for you. However, the usual dosage is 1,500 milligrams per day in three same doses of 500 mg.
The dining of the daily dose into three parts is required to keep the Berberinpiegel stable in your blood, as this alkaloid has a short half -life. Another reason for the division of the daily dose is that a large single dose can annoy your stomach with cramps and diarrhea.
take the preparation for your meal or shortly afterwards to use Berber's ability to reduce the increase in blood sugar and lipid levels that occurs immediately after a meal.
NOTE ... When buying Berberin-HCL, make sure that you do not confuse it with Berberol (a brand name for another product) or Berberrubin (a metabolite or a substance that is formed in your metabolism or is necessary for it).
Side effects and risks of taking Berber
Berberine has an excellent security balance. The side effects are low and are related to digestion ... stomach pain, cramps, flatulence, constipation and diarrhea.
diabetics and hypertensioners have to be careful if they control their condition with medication such as metformin or statins ... because Berber can naturally lower blood sugar and blood pressure and they may suffer from hypos.
If you remember to take the Berberin preparation in the long term, i.e. for more than three months, you should consult your doctor.
Stilling and pregnant women should also get advice from their family doctor before taking a Berberin provision.