The effect of John's wort on depression: facts and studies

The effect of John's wort on depression: facts and studies

St. John's wort, also known as Hypericum perforatum, is a plant that has been used for the treatment of depression for centuries. The biochemical effect of this plant in the treatment of depression and clinical studies on their effectiveness are the focus of this investigation. In addition, the possible side effects and interactions of St. John's wort as well as the corresponding recommendations and dosage recommendations for the use of this plant for the treatment of depression are also considered. The present analysis provides a scientific perspective on the use of St. John's wort as a potential treatment option for depression.

The biochemical effect of St. John's wort in the treatment of depression

St. John's wort, also known as Hypericum perforatum, has long been used to treat light to moderate depression. The biochemical effects of St. John's wort are diverse and play a crucial role in relieving depressive symptoms.

One of the main effects of St. John's wort is the inhibition of the resumption of neurotransmitters such as serotonin, dopamine and noradrenaline. This effect increases the concentration of these messenger substances in the brain, which can lead to a mood and reduction of depressive symptoms.

In addition, St. John's wort also acts as a monoaminoxidase inhibitor (Mao-inhibitor), which means that it reduces the activity of the enzyme monoaminoxidase. This leads to an increased concentration of neurotransmitters in the brain, which in turn can improve the mood.

Another biochemical effect of St. John's wort is its anti -inflammatory activity. Depression is often associated with an increased inflammatory reaction in the body, and St. John's wort can contribute to an improvement in depressive symptoms by reducing inflammation.

In addition, John's wort also has an antioxidant effect, which means that it can neutralize free radicals in the body. This can help support the brain function and improve the general mood.

The biochemical effect of St. John's wort in the treatment of depression is complex and diverse. By combining different mechanisms of action, St. John's wort can help relieve the symptoms of depression and improve general well -being. Further information on the biochemical effects of St. John's wort is available in clinical studies and research.

clinical studies on the effectiveness of St. John's wort in depression

In order to evaluate the effectiveness of St. John's wort in the treatment of depression, numerous clinical studies have been carried out in recent decades. The results of these studies provide important information on the actual effect of the herb and help to make well -founded treatment decisions.

One of the best -known studies on this topic is the so -called "Hypericum Depression Trial Study Group". This large -scale study was carried out in the USA and examined the effectiveness of St. John's wort compared to a placebo and a conventional antidepressant. The results showed that St. John's wort is as effective as conventional antidepressants in light to moderate depression, but is associated with fewer side effects.

A meta -analysis of 29 studies published in 2008 confirmed the effectiveness of St. John's wort in the treatment of depression. The analysis showed that people who took St. John's wort show a significant improvement in their depressed symptoms compared to placebo.

Another important result comes from a study by Cochrane Collaboration from 2015. This meta -analysis of 35 studies showed that St. John's wort is not effective in the treatment of moderate to severe depression. The study suggests that the herb should be used especially in light to moderate depression.

Side effects and interactions of St. John's wort

Although St. John's wort is considered effective treatment of depression, it also carries the risk of side effects and interactions with other medication. It is important to understand these potential risks to ensure the safe application of St. John's wort.

side effects

Some of the most common side effects of St. John's wort are:

• nausea
• constipation
• dry mouth
• insomnia
• fatigue
• light sensitivity

These side effects are usually mild and temporary, but can be disturbing in some people. It is important to consult a doctor if these side effects are serious or stop.

Interactions

St. John's wort can also cause interactions with other drugs, especially with:

• Control prevention pills
• blood thinner
• antidepressants
• antibiotics
• antidepressants

The intake of St. John's wort in combination with these medication can lead to reduced effects or increased side effects. It is therefore important to speak to a doctor before using St. John's wort, especially if other medications are already taken.

recommendations and dosage recommendations for the use of St. John's wort for the treatment of depression

When it comes to the use of John's wort to treat depression, it is important to consider the correct dosage. Here are some recommendations and dosage recommendations that must be observed when using St. John's wort:

• Before using St. John's wort to treat depression, always consult a doctor first. A doctor can best assess whether St. John's wort is suitable for your specific situation.
• Do not use St. John's wort in combination with other antidepressants, as this can lead to serious interactions.
• be sure to only take St. John's wort in the right dosage in order to achieve the best possible results and to avoid side effects.
• Note possible interactions with other medication, especially if you take other prescription medication.

dosage recommendations

When dosing of St. John's wort for the treatment of depression, the following recommendations must be taken into account:

• adults can usually take 900 to 1800 mg of St. John's wort per day, divided into two or three doses.
• Highly concentrated St. John's wort extracts should be taken in lower quantities because they are more concentrated and therefore require lower dosage.
• It can take a few weeks for the full effect of St. John's wort to be felt. Therefore, patience and consistency is important when taking it.

table: dosage recommendations

It is important to carefully follow these recommendations and dosage recommendations in order to achieve the best possible results when using St. John's wort to treat depression. Remember to consult a doctor before starting St. John's wort to minimize possible risks.

conclusion