Serotonin-modulating probiotics

Serotonin-modulating probiotics

serotonin-modulating probiotics

by Prof. Gene Bruno, MS, MHS, RH (AHG) Huntington College of Health Sciences

Research on probiotics has exploded in the past ten years. It has certainly been shown that probiotics have a positive impact on Vigura 1-3 and immune function4-6, but research has also shown that probiotics can also influence other aspects of our biochemistry and health. Such a range is serotonin modulation.

Psychobiotics
According to Wall et al.7, the term "psychobiotics" was shaped to describe a new class of probiotics with relevance for psychiatry. These probiotics can work through their ability to produce various biologically active connections, such as peptides and mediators, which are usually associated with the neurotransmission of mammals. It was reported that several molecules with neuroactive functions, including serotonin, come from bacteria in the human intestine and were isolated from bacteria. Secret neurotransmitters of bacteria in the intestinal lumen can cause epithelial cells to release molecules, which in turn modulate the neural signal transmission within the enteric nervous system and consequently signal brain function and behavior of the host. As a result, probiotic bacteria that contain/produce neurochemicals can be regarded as transport vehicles for neuroactive connections, and as such probiotic bacteria may have the potential as a therapeutic strategy in prevention and/or treatment of certain neurological and neurophysiological conditions.

Examples of serotonin-modulating probiotics
B. in animal experiments The oral intake of bifidobacteria infantis increased plasma levels from tryptophan, the forerunner of serotonin, which indicates that coming bacteria have the ability to influence the tryptophan metabolism and possibly act as antidepressants.8 Another example is a study in the Caco-2 cells and Darm tissue of mice after treatment were examined lactobacillus rhamnosus gg. The results showed that the mRNA of the serotonin transporter (Sert) and the serotonin transporter protein (Sert-P) were higher after treatment than in the control group. This investigation has clearly shown the lactobacillus rhamnosus gg can regulate the Sert-MRNA and SERT-P levels in intestinal epithelial cells and intestinal tissues.

potential for appetite control
In addition to their relevance for psychiatry, serotonin-modulating probiotics can also be valuable with regard to appetite control. It is believed that gastrointestinal hormone release and the regulation of appetite and body weight have come out of balance in the event of obesity. The researchers examined the expression of the serotonergic system in the stomach tissue and in the serum of obese and non -obese people. The results were that the serum serotonin in obese people was reduced compared to non -obese people (p <0.05). In view of the established role of serotonin in appetite control, the improvement of his expression can prove to be effective by supplementing with probiotics to promote healthy serotonin levels.

refer to
1 Gupta V, Garg R. Probiotics. Indian J med Microbiol . 2009 Jul-Sep; 27 (3): 202-9. 2 Goldin BR, Gorbach Sl. Clinical indications for probiotics: an overview. Clin Infect Dis . February 1, 2008; 46 Appendix 2: S96-100. 3 Hojsak I., Abdović S., Szajewska H., Milošević M., Krznarić Ž, Kolaček S. lactobacilli GG in the prevention of nosocomial infections of the gastrointestinal tract and respiratory tract. Pädiatrie 2010; 125: E1171 - E1177. 4 Elmadfa I, Klein P, Meyer Al. Session 7: Use of prebiotics and probiotics against pathologies: immunestimulating effects of lactic acid bacteria in vivo and in-vitro. Proc Nutr Soc. 2010; 69: 416–420. 5 Cosenza L., Nocererino R., Di Scala C., Di Costanzo M., Amoroso A., Leone L., Paparo L., Pezzella C., Aitoro R., Berni Canani R. Bugs for Atopy: The lactobacillus rhamnosus GG strategy for prevention and treatment of allergies Children. benefit microbes. 2015; 6 (2): 225-32. 6 Ashraf R., Shah NP. Stimulation of the immune system by probiotic microorganisms. Crit Rev Food Sci Nutr. 2014; 54 (7): 938-56. 7 Wall R, Cryan JF, Ross RP, Fitzgerald GF, Dinan TG, Stanton C. Bacterial neuroactive compounds that are produced by psychobiotics. ADV Exp Med Biol . 2014; 817: 221-39. 8 Patterson E, Cryan JF, Fitzgerald GF, Ross RP, Dinan TG, Stanton C. Darmikrobiota, the pharmaceuticals that they produce and accommodate health. Proc Nutr Soc. Nov. 2014; 73 (4): 477-89. 9 Y. Ritze, A. Schollenberger, M. Hamze Sinno, N. Bühler, M. Böhle, G. Bárdos, H. Sauer, I. Mack, P. Enck, S. Zipfel, T. Meile, A. Königsrainer, M. Kramer, SC Bischoff, and Leptinr-Expression and peripheral serotonin are mis-regulated in humans. Neurogastroenterol Motil. 2016 jun; 28 (6): 806-15.

Professor Gene Bruno, MS, MHS, The Provost for Huntington College for Health Sciences, is a nutritionist, herbalist, writer and educator. For more than 37 years, he has been forming and trained in natural product dealers and medical specialists, has researched and formulated natural products for dozens of food supplements and has written articles and integrative health issues for trade and consumers publications and peer reviewed publications. It can be reached at gbruno@hchs.edu.

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