Resveratrol prevents the loss of bone density in patients with type 2 diabetes

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Resveratrol verhindert den Verlust der Knochendichte bei Patienten mit Typ-2-Diabetes Von Prof. Gene Bruno, MS, MHS, RH(AHG), Huntington University of Health Sciences Patienten mit Typ-2-Diabetes (T2DM) haben ein erhöhtes Frakturrisiko, und die Forscher suchen ständig nach Strategien, um Knochenschwund zu verhindern und das Frakturrisiko zu reduzieren. Eine potenziell vielversprechende Strategie ist der Einsatz von Resveratrol. Präklinische Forschung zu Resveratrol für die Knochengesundheit Tierstudien haben gezeigt, dass Resveratrol Knochenschwund verhindert, die Mineraldichte aufgrund von Immobilisierung, höherem Alter und Ovariektomie reduziert1-4 und die Knochenheilung und -reparatur nach chirurgischen Eingriffen oder Traumata bewirkt.5-6 Es fördert die Osteoblastogenese, antagonisierte Osteoklasten in vitro,7-9 und verstärkte …
Resveratrol prevents the loss of bone density in patients with type 2 diabetes by Prof. Gene Bruno, MS, MHS, RH (AHG), Huntington University of Health Sciences Patients with type 2 diabetes (T2DM) have an increased risk of fracture, and the researchers are constantly looking for strategies to prevent bone loss and the fracture risk reduce. A potentially promising strategy is the use of resveratrol. Preclinical research on resveratrol for bone health Animal studies have shown that resveratrol prevents bone loss, reduced mineral density due to immobilization, older age and ovariectomy1-4 and the bone healing and repair after surgical interventions or trauma. 5-6 In vitro, 7-9 and reinforced ... (Symbolbild/natur.wiki)

resveratrol prevents the loss of bone density in patients with type 2 diabetes

by Prof. Gene Bruno, MS, MHS, RH (AHG), Huntington University of Health Sciences

Patients with type 2 diabetes (T2DM) have an increased risk of fracture, and the researchers are constantly looking for strategies to prevent bone loss and reduce the risk of fracture. A potentially promising strategy is the use of resveratrol.

preclinical research on resveratrol for bone health Animal studies have shown that resveratrol prevents bone loss, reducing mineral density due to immobilization, older age and ovariectomy1-4 and bone healing and repair after surgical interventions or trauma. Osteoblastogenesis, antagonized osteoclasts in vitro , 7-9 and reinforced vitamin D receptor activity.

A clinical study in humans with resveratrol for bone health In view of these positive preclinical results, a double-blind, randomized, placebo-controlled study11 was carried out in order to examine the effects of resveratrol on the bone mineral density (BMD) and the biomarkers of the calcium metabolism at T2DM patients. A total of 192 outpatient T2DM patients were randomized and received 500 mg/day (RESV500 arm), 40 mg resveratrol/day (RESV40 arm) or placebo for six months. BMD, bone mineral content (BMC), serum calcium, phosphorus, alkaline phosphatase and 25 hydroxy vitamin D were measured at the beginning of the course and after six months. The results were that during the follow-up examination, the calcium concentrations climbed in all patients, while the fluctuations in the alkaline phosphatase within the group were higher in both resveratrol arms and 25 hydroxy vitamin D only increased in the ResV500 arm, without differences between the groups. The full body BMD decreased significantly in the placebo group, while the full body BMC decreased both in the placebo and the RESV40 arm. No significant changes in the BMD and BMC values ​​occurred in the RESV500 arm. The adjusted medium differences of the change compared to the starting value were significantly different for the full body BMD (0.01 vs-0.03 g/cm2, p = 0.001), the full body BMC (4.04 vs-58.8 g, p <0.001.). ), Full body t-score (0.15 vs-0.26) and serum phosphorus (0.07 vs-0.01 µmol/l, p = 0.002). In subgroup analyzes, the BMD values ​​of the patients treated with RESV500 in patients with lower calcium and 25-hydroxy vitamin D values ​​rose to higher values ​​for alcohol drinkers. In summary, it can be said that the supplementation with 500 mg resveratrol prevented the loss of bone density in patients with T2DM, especially in patients with unfavorable starting conditions.

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    • Professor Gene Bruno, MS, MHS, The provost for Huntington College for Health Sciences, is a nutritionist, herbalist, author and educator. For more than 37 years, he has trained and trained natural product retailers and medical staff, researched and formulated natural products for dozens of food supplements and formulated articles on nutrition, herbal medicine, nutrotquional agents and integrative health issues for trade and consumers. It can be reached at gbruno@hchs.edu.

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