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Resveratrol as an anti-inflammatory agent

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Resveratrol as an Anti-Inflammatory Agent By Prof. Gene Bruno, MS, MHS, RH(AHG) Huntington University of Health Sciences Resveratrol is a nutraceutical that originally became famous as a compound found in red wine that may contribute to the "French paradox" - the unexpectedly low mortality rate from cardiovascular disease in the Mediterranean population despite the relatively higher intake of saturated fats.1 Subsequently, excitement blossomed when studies showed that resveratrol helped activate the SIRT-1 gene, which is linked to longevity.2 While additional research since then has shown a number of potential health benefits associated with resveratrol supplementation, the subject of this blog is the effectiveness of resveratrol as...

Resveratrol als entzündungshemmendes Mittel Von Prof. Gene Bruno, MS, MHS, RH(AHG) Huntington University of Health Sciences Resveratrol ist ein Nutrazeutikum, das ursprünglich als eine Verbindung aus Rotwein berühmt wurde, die zum „französischen Paradoxon“ beitragen könnte – der unerwartet niedrigen Sterblichkeitsrate durch Herz-Kreislauf-Erkrankungen in der Mittelmeerbevölkerung trotz der relativ höheren Aufnahme gesättigter Fette .1 Anschließend blühte die Aufregung auf als Studien zeigten, dass Resveratrol dazu beitrug, das SIRT-1-Gen zu aktivieren, das mit Langlebigkeit verbunden ist.2 Während zusätzliche Forschung seitdem eine Reihe potenzieller gesundheitlicher Vorteile im Zusammenhang mit einer Resveratrol-Supplementierung gezeigt hat, ist das Thema dieses Blogs die Wirksamkeit von Resveratrol als …
Resveratrol as an Anti-Inflammatory Agent By Prof. Gene Bruno, MS, MHS, RH(AHG) Huntington University of Health Sciences Resveratrol is a nutraceutical that originally became famous as a compound found in red wine that may contribute to the "French paradox" - the unexpectedly low mortality rate from cardiovascular disease in the Mediterranean population despite the relatively higher intake of saturated fats.1 Subsequently, excitement blossomed when studies showed that resveratrol helped activate the SIRT-1 gene, which is linked to longevity.2 While additional research since then has shown a number of potential health benefits associated with resveratrol supplementation, the subject of this blog is the effectiveness of resveratrol as...

Resveratrol as an anti-inflammatory agent

By Prof. Gene Bruno, MS, MHS, RH(AHG)

Huntington University of Health Sciences

Resveratrol is a nutraceutical that originally became famous as a compound found in red wine that may contribute to the "French paradox" - the unexpectedly low mortality rate from cardiovascular disease in the Mediterranean population despite relatively higher saturated fat intake.1 Subsequently, excitement blossomed when studies showed that resveratrol contributed to the SIRT-1 gene which is associated with longevity.2 While additional research has since shown a number of potential health benefits associated with resveratrol supplementation, the topic of this blog is the effectiveness of resveratrol as an anti-inflammatory agent.

Whilein vitroand animal studies certainly demonstrated the anti-inflammatory effects of resveratrol, this nutraceutical was able to effectively suppress oxidative and inflammatory stress even in healthy people with just 40 mg/day.3 This was demonstrated by the reduction of inflammatory markers such as TNF-alpha, IL-6 and C-reactive protein, with no changes in the placebo group. Another study in postmenopausal women with osteoarthritis pain concluded that 75 mg of resveratrol twice daily significantly reduced pain and improved overall well-being.4

Ulcerative colitis has also responded to treatment with resveratrol. In one study5, 56 UC patients who received 500 mg of resveratrol per day showed significant improvement in symptoms, reduced malondialdehyde (a highly reactive compound for oxidative stress) and increased superoxide dismutase (SOD), as well as total antioxidant capacity. In other studies6 of 50 UC patients, 500 mg of resveratrol per day reduced the activity of inflammatory compounds, including TNF-α, hs-CRP, and NF-κB activity.

Additionally, in a study7 of firefighters who received 100 mg of resveratrol per day for 90 days, plasma biomarkers of inflammation following a physical fitness test were reduced, including IL-6 and TNF-α.

Resveratrol should clearly be considered as part of a protocol for patients requiring anti-inflammatory treatment.

References:

  • N. Labinskyy, A. Csiszar, G. Veress, G. Stef, P. Pacher, G. Oroszi, J. Wu, Z. Ungvari. Gefäßdysfunktion im Alter: Potenzielle Wirkungen von Resveratrol, einem entzündungshemmenden Phytoöstrogen. Aktuelle medizinische Chemie 2006; 13(9):989-96.
  • Borra MT, Smith BC, Denu JM. Mechanismus der humanen SIRT1-Aktivierung durch Resveratrol. J. Biol. Chem. J. Biol. 29. April 2005;280(17):17187-95.
  • Ghanim H, Sia CL, Abuaysheh S, Korzeniewski K, Patnaik P, Marumganti A, Chaudhuri A, Dandona P. Eine entzündungshemmende und reaktive Sauerstoffspezies unterdrückende Wirkung eines Resveratrol-haltigen Extrakts aus Polygonum cuspidatum. J Clin Endocrinol Metab. 2010 Sep;95(9):E1-8.
  • Wong RHX, Evans HM, Howe PRC. Die Supplementierung mit Resveratrol reduziert das Schmerzempfinden bei postmenopausalen Frauen. Menopause. 2017 Aug; 24(8): 916-922.
  • Samsamikor M, Daryani NE, Asl PR, Hekmatdoost A. Resveratrol Supplementation und oxidativer/antioxidativer Status bei Patienten mit Colitis ulcerosa: Eine randomisierte, doppelblinde, placebokontrollierte Pilotstudie. Arch Med Res. 2016 Mai;47(4):304-9.
  • Samsami-Kor M, Daryani NE, Asl PR, Hekmatdoost A. Entzündungshemmende Wirkungen von Resveratrol bei Patienten mit Colitis ulcerosa: Eine randomisierte, doppelblinde, placebokontrollierte Pilotstudie. Arch Med Res. 2015 Mai;46(4):280-5.
  • Macedo RC, Vieira A1, Marin DP2, Otton R3. Die Auswirkungen einer chronischen Resveratrol-Supplementierung bei militärischen Feuerwehrleuten werden einem körperlichen Fitnesstest unterzogen – einer placebokontrollierten Doppelblindstudie. Chem. Biol. Interaktion. 5. Februar 2015; 227: 89-95.

    • Professor Gene Bruno, MS, MHS, provost for Huntington College of Health Sciences, is a nutritionist, herbalist, author and educator. For more than 37 years, he has educated and trained natural products retailers and healthcare professionals, researched and formulated natural products for dozens of dietary supplement companies, and authored articles on nutrition, herbal medicine, nutraceuticals, and integrative health topics for trade and consumer magazines and peer-reviewed publications. He can be reached at gbruno@hchs.edu.

    • Herzkreislauferkrankung
    • Französisches Paradoxon
    • niedrige Sterberate
    • Mittelmeerbevölkerung
    • Prof. Gene Bruno Blog
    • Rotwein
    • Resveratrol

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