New study confirms undeniable connection between intestinal bacteria and Alzheimer's
New study confirms undeniable connection between intestinal bacteria and Alzheimer's
Alzheimer's disease is a growing global health problem, although the number of those affected will probably increase significantly in the coming decades. It is estimated that around 14 million people will suffer from Alzheimer's in the United States by 2050, compared to 6.2 million in 2021. This increase in Alzheimer's cases underlines the urgent need for effective prevention strategies and treatments in order to alleviate the effects on individuals and families, and health systems.
A publication recently published in the Journal of Alzheimer's IMEASE shows a strong connection between Alzheimer's disease and substances that are produced by intestinal bacteria. The researchers argue that their results provide "undeniable" proof that intestinal microbes play a crucial role in the development of Alzheimer's.
The intestinal brain axis has recently been the subject of considerable scientific studies and discussions, since more and more evidence indicates that the microscopic residents of our gastrointestinal tract directly influence our central nervous system. This bidirectional communication channel enables the brain to transmit chemical signals for appetite and digestive settlement to the intestine, while the intestinal bacteria probably release different metabolites that impair the brain function.
This has led to theories that a person's microbiom composition could affect their risk of Alzheimer's, even though this connection remained unconfirmed. In order to solve the debate, the authors of the new study recruited 89 participants aged 65 to 85, some of whom were healthy and others experienced a different cognitive breakdown. The researchers used positron emission tomography (PET) to search for the brain of the participants for Alzheimer's-typical amyloid plaques, and collect blood samples to examine metabolites of intestinal bacteria.
The results showed that people with more amyloid plaques in their brains tend to show increased lipopolysaccharide levels in the blood. These molecules, which are available on the outer membrane of certain bacteria, are known to promote the formation of amyloid plaques and to increase inflammation in the brain. Alzheimer's patients also had higher blood levels of short-chain fatty acids such as acetate and Valerat, both of which are produced by certain intestinal bacteria and are connected to brain inflammation.
Higher concentrations of other compounds that interfere with endothelial cells and impair the integrity of the blood-brain barrier were also demonstrated in people with increased amyloid plaque levels, which indicates another possible path, could influence the development of Alzheimer's.
Conversely correlated lower amyloid plaque levels with increased concentrations of a short-chain fatty acid called Butyrat, from which it is known to protect neurons by reducing brain inflammation.
According to study author Moira Marizzoni, the "results are undeniable: Certain bacterial products of the intestinal flora correlate with the amount of amyloid plaques in the brain." Ezoic-AT-0 Large-Leaderboard-2 Large-Leaderboard-2690 ADTester container ATester-Container-690 "Data-Ez-Name =" Healthy_Holistic_Living_Com-Large-Leaderboard-2 ">
Nevertheless, co-author Giovanni Frisoni warns against celebrating too early, since this knowledge will probably not lead to a healing of neurodegenerative diseases. Instead, it can facilitate more effective identification of risk opera and enable previous interventions.
First, the bacterial strains in the "cocktail" would have to be identified, he says. "Then a neuroprotective effect could only be effective in a very early stage of illness, whereby the focus is more on prevention than on therapy."
alternative treatments and preventive measures
Alternative treatments and preventive measures have gained attention in connection with Alzheimer's disease. There are several changes to the lifestyle, nutritional supplements and herbs that contribute to the health of the brain and may be able to delay the start or progression of Alzheimer's disease. These approaches should be regarded as a supplement to the knowledge of the intestinal brain axis.
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Healthy eating:
A balanced diet that is rich in fruit, vegetables, whole grains, lean protein and healthy fats can support the general health of the brain. The Mediterranean and Dash diet (Dietary Approaches to Stop Hypertension) are often recommended because of their potential brain-protecting effects.
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Regular training:
It has been shown that regular physical activity improves cognitive function and reduces the risk of developing Alzheimer's. Aerobic exercises in particular were associated with an increased volume of the hippocampus and an improved memory function.
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mental stimulation:
The participation in activities that challenge the brain, such as puzzles, games and learning new skills, can help to maintain the cognitive function and to reduce the risk of Alzheimer's disease.
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omega-3 fatty acids:
These essential fatty acids occurring in fish, nuts and seeds were associated with improved cognitive function and reduced inflammation. Some studies indicate that an Omega-3 supplement in Alzheimer's prevention can be an advantage.
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turmeric:
This connection contained in turmeric has antioxidant and anti -inflammatory properties. Research shows that curcumin can help reduce amyloid plaques and improve cognitive function in Alzheimer's patients.
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ginkgo biloba:
This vegetable preparation has been used for centuries to improve memory and cognitive function. Some studies indicate that Ginkgo Biloba can help slow down the cognitive decline in people with Alzheimer's disease.
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resveratrol:
This antioxidant, which occurs in red wine, grapes and berries, was associated with an improved cognitive function and a reduced risk of Alzheimer's. However, further examinations are required to confirm its effectiveness.
The growing number of research results on the connection between intestinal bacteria and Alzheimer's disease offers new insights into possible preventive measures and treatments. Although healing remains difficult to understand for Alzheimer's, the acceptance of a healthy lifestyle, including nutrition, movement and mental stimulation, as well as the consideration of nutritional supplements and herbs can help to maintain the health of the brain and to reduce the risk of developing this weakening disease. By integrating these approaches, we can work out to alleviate the increasing effects of Alzheimer's disease on the individual and society.
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