Researchers have found a way to grow teeth back

Researchers have found a way to grow teeth back

The need for artificial teeth could become superfluous in the future, since an antibody was discovered that triggers the back of lack of teeth. This antibody blocks the function of a gene called usag-1 and thus increases the presence of specific growth factors. Over time, this could offer people the opportunity to have brand new, radiant teeth growing back.

In a study published in Science Advances, a group of scientists explains their successful experiment to induce dental growth in genetically modified mice. In these mice, a tooth layer was developed, a state in which some teeth do not develop. However, the USAG 1 antibody was injected as pregnant mice on this line, their descendants showed normal tooth development. Remarkably, a single dose of the antibody even triggered the growth of a completely new tooth in normal mice.

The researchers decided to concentrate on the USAG 1 gene because it is known to suppress two signal molecules, BMP and Wnt, which are of crucial importance for the tooth development. However, these molecules also regulate the growth of numerous other organs, so that every disorder can lead to serious side effects.

During research, the team examined a number of monoclonal antibodies that change the interaction between the USAG-1, BMP and WNT. Some of them caused serious birth defects, but finally they identified a specific antibody that blocked the association's association with BMP without influencing Wnn.

This discovery enabled them to trigger tooth growth without adverse side effects. The researchers came to the conclusion that USAG-1 hindered tooth growth by binding to BMP and reducing its activity.

Study author Katsu Takahashi said in a statement: "We knew that the oppression of USAG-1 promotes tooth growth." However, we didn't know if it would be enough. " The results of the team suggest that the inhibition of genetic activity enables a sufficient increase in the BMP to stimulate the growth of new teeth.

While this method is far from being suitable for tests in humans, the scientists tested the antibody of ferrets, the tooth patterns of which are similar to those of humans. They are also diphyodontic, which means that they have milk teeth that are later replaced by adult teeth.

The results showed that the treatment in ferrets was equally effective, since a single injection of the antibody led to the development of a completely new tooth. This implies that the method could possibly work in humans, but safety concerns must be taken into account before such tests can be carried out. For the time being, the researchers want to repeat the experiment on other mammals such as pigs and dogs.

The research team is optimistic that their groundbreaking work with the USAG 1 antibody could lay the foundation for future dental treatments, especially for those who suffer from dental loss due to age or illness. However, they emphasize that the way to try people is not easy and will require a variety of additional steps.

The greatest concern is the complexity of the safe and effective use of this technique in humans. Although it is successful in mice and ferrets, it is crucial to determine whether the same method can be used in larger mammals as pigs and dogs without causing unwanted side effects. These larger mammals are physiologically closer to humans, which makes them more representative models for such studies.

The researchers must also further examine the possible long-term effects of the inhibition of the USAG 1 gene. Due to its role in regulating the growth of other organs, it could have unforeseen consequences that have not yet been visible in the short -term studies.

At the same time, the team will examine opportunities to refine and control the application of the USAG 1 antibody. The goal is to ensure that the growth of a single tooth can be specifically and permanently stimulated without impairing the neighboring teeth or tissue.

The researchers hope to work with dentists and geneticists in the future in order to deepen in the effects of this research on human health. In doing so, they want to bring us a step closer to a world in which tooth loss can be remedied by simply causing a new tooth to grow so that dentures belong to the past.

This study undoubtedly represents significant progress in dental regeneration research. However, it is clear that there is still a lot to do before we can fully understand the potential of this innovative approach.

Are you looking for more detailed information on natural remedies for oral health?
>> Take a look at my free e-book " The ultimate guide for natural solutions for dental health" <<