Study: Temporally limited food for breast cancer survivors

reference

Kirkham aa, Ford Kl, Topolnynyski J, et al. Limited food for reducing cardiovascular risk in older breast cancer survivors: a one -arm feasibility study. JACC: Cardiooncology . 2022; 4 (2): 276-278.

study goal

The effectiveness of a temporary diet should be assessed in reducing cardiovascular risk in breast cancer survivors

Key to take away

Fasting during the week for 16 hours a day can reduce the cardiovascular risk of breast cancer patients.

design

one -armed feasibility study

participant

There were 22 breast cancer survivors (average age: 66 years ± 5 years) with an average body mass index (BMI) of 31.5 kg/m 2 , which had undergone an anthracycline chemotherapy within the last 1 to 6 years (mean: 3 years ± 1 year). Most participants (68 %; n = 15) either had a metabolic syndrome or were considered for a pharmacological intervention to reduce cardiovascular risk. Fifty percent of the participants had been irradiated on the left and 91 percent took tamoxifen with or without aromata seeds.

intervention

The participants fasted 16 hours a day from Monday to Friday and only ate between 12 and 8 p.m. for two months. This temporarily limited meal plan is abbreviated with Tre 16: 8.

study parameters

The researchers assessed the Framingham scores, the metabolic syndrome, age, smoking/non-smoking status and the status of high blood pressure treatment on risk factors for cardiovascular diseases.

They determined the following laboratory values ​​after fasting after fasting after one of the days of the week, on which the participant followed the time-limited eating protocol: glucose, total cholesterol and high-density-lipoprotein- (HDL) mirror.

In physical examinations, blood pressure and waist size were measured. The researchers analyzed visceral fat tissue using magnetic resonance imaging (MRI). They used the 8-point bioimpedance to assess the fat and fat-free mass of the participants.

primary result

Risk for cardiovascular diseases, metabolic syndrome, visceral adipose tissue, fat mass and fat-free mass

most important knowledge

After two months of time-limited food intake, the mean Framingham risk for cardiovascular diseases dropped significantly from 10.9 % to 8.6 % ( p = 0.037). There was significantly reduced amounts of visceral adipose tissue ( p = 0.009), total body fat mass ( p = 0.046) and medium body mass ( p = 0.025).

There was no significantly improved results in total cholesterol, HDL levels, in systolic blood pressure and in the middle BMI.

of the 15 breast cancer survivors who either suffered from a metabolic syndrome at the beginning of this study or for a pharmacological intervention to reduce cardiovascular risk remained after two months of time -limited diets in this category.

transparency

Study financing sources for this study are implied, but not explicitly stated, and the authors have given all disclosures.

effects and restrictions for practice

This preliminary study presented some potential clinical advantages of time-limited food (TEE) for breast cancer survivors, in which there is already an increased risk of cardiovascular diseases. Since breast cancer survivors are exposed to a higher risk of death due to cardiovascular diseases, improving the accessibility of integrative interventions for treatment is very important.

Time-limited food can not only reduce the risk of cardiovascular diseases in breast cancer survivors, but there are also a number of studies that indicate that those who practice TRE intentionally or unintentionally can also improve their breast cancer for the time. Fasting 13 hours a night (TR 13:11), a significantly reduced risk of a re-occurrence of breast cancer, although there were no significant differences in the mortality rate. ^{1 This study showed that the HBA value with any additional fasting time of 2 hours a day is significantly improved 1C Duration of sleep. 1 However, there is contradictory data on the connection between breast cancer forecast and HBA _{1c 7.8 It is clear that improved sleep is significantly reduced in the inflammatory biomarker in breast cancer patients.}}

For example, in a study with 97 people with advanced breast cancer, the overall mortality was significantly reduced through improved sleep.

Further studies should be carried out to distinguish whether the regular meal times or the fasting aspects of the temporary food are most advantageous, or whether it is the combination of both.

The study examined here dealt with possible undesirable symptoms such as headache and irritability.

Systemic inflammation are associated with cancer and its recurrence. The easily measurable inflammatory marker C-reactive protein (CRP) was associated with a poor forecast for breast cancer. ^{12 Results of the National Health and Nutritional Examination 2009–2010 indicate that longer fasting intervals were connected to breast cancer patients with significantly reduced CRP values. Breast cancer patients with high CRP values ​​can be a considerable intervention to improve their prognosis and reduce inflammation.}

Studies on TRE Breast Cancer patients indicate that we may be able to stray, who likes to benefit most if we collect more data. In a study with almost 2,000 Chinese women, the results showed that Tre may be more clinically relevant for reducing breast cancer risk for those who have previously eaten after 10 p.m. over a longer period of time (e.g. over 20 years), and for those who have eaten regularly in between 12 to 2 a.m. a BMI under 25. 4

Although TRE is a low -risk and inexpensive option, potential side effects must be taken into account. The study examined here dealt with possible undesirable symptoms such as headache and irritability. Other studies have also found similar symptoms. ^{13 Rare side effects of TR are vomiting, diarrhea, nausea, constipation, dizziness, increased thirst and tiredness. 13 Studies have shown that these side effects generally leave over time.}

As with any integrative nutritional protocol, it is of the utmost importance to assess each patient individually and to clarify it about the risks and advantages of a certain Tre protocol so that he can make a well-founded decision about whether he wants to continue with the time-limited diet.