Study: Is Amla the next weapon against heart diseases?

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Von: Natur.wiki Autoren-Team

Referenz Biswas TK, Chakrabarti S, Pandit S, Jana U, Dey SK. Pilotstudie zur Bewertung der Verwendung von Emblica officinalis standardisierter Fruchtextrakt zur kardiorespiratorischen Verbesserung und zum antioxidativen Status von Freiwilligen mit Rauchergeschichte. J Herb Med. 2014;4(4):188-194. Design Doppelblinde, randomisierte, Placebo-kontrollierte Studie Teilnehmer Am Ende der Studie (Tag 60) waren 20 Männer in der Interventionsgruppe und 10 in der Kontrollgruppe (im Alter von 20 bis 60 Jahren) auswertbar. Alle Teilnehmer waren seit mindestens 10 Jahren Raucher (>15 Zigaretten/Tag). Viele hatten Symptome einer kardiorespiratorischen Beeinträchtigung, einschließlich Husten, schlechter Immunstatus (wiederkehrende Infektionen), kardiovaskuläre Anomalien (beurteilt mit Elektrokardiogramm [ECG]) und/oder Unregelmäßigkeiten des Lipidprofils, verminderter …
Reference Biswas TK, Chakrabarti S, Pandit S, Jana U, Dey SK. Pilot study to evaluate the use of EMBLICA Officinalis Standardized Frucht Extract for Cardio -Piratory improvement and the antioxidant status of volunteers with smoking history. J Herb Med. 2014; 4 (4): 188-194. Design double-blind, randomized, placebo-controlled study participant at the end of the study (day 60) 20 men in the intervention group and 10 were evaluated in the control group (aged 20 to 60 years). All participants have been smokers (> 15 cigarettes/day) for at least 10 years. Many had symptoms of cardio -piratory impairment, including coughing, poor immune status (recurring infections), cardiovascular anomalies (assessed with electrocardiogram) and/or irregularities of the lipid profile, reduced ... (Symbolbild/natur.wiki)

Reference

Biswas TK, chakrabarti s, pandit s, jana u, dey sk. Pilot study to evaluate the use of emblica officinalis Standardized fruit extract for cardiorespiratory improvement and the antioxidant status of volunteers with smoking history. j Herb med. 2014; 4 (4): 188-194.

Design

double-blind, randomized, placebo-controlled study

participant

At the end of the study (day 60), 20 men in the intervention group and 10 were evaluated in the control group (aged 20 to 60 years). All participants have been smokers (> 15 cigarettes/day) for at least 10 years. Many had symptoms of cardio -piratory impairment, including coughing, poor immune status (recurring infections), cardiovascular anomalies (assessed with electrocardiogram [ECG]) and/or irregularities of the lipid profile, reduced appetite or digestive function or bad libido. The exclusion criteria included people under the age of 20 or over 60, less cigarette consumption during the study time (<15 cigarettes/day), jaundice, venereal diseases, diabetes mellitus, radiation exposure and serious lack of nutrients or chronic diseases of any kind (e.g. carcinoma, manifest heart diseases, hemoglobin below 6 g/dl).

Intervention

group I received 250 mg of it emblica officinalis ( phyllanthus emblica , Indian gooseberry, amla)-Fruchtextrakt (EOE) with at least 60 % (f/f) hydrolyzic tannoid (Emblicanin-A, Emblicanin-B, Pedunculagin, Punigluconin) twice a day or after meals. The study used a branded product, Capros® from Natreon Inc (New Brunswick, New Jersey). The control group received 250 mg placebo capsules with the same auxiliary substances as the intervention group (microcrystalline cellulose, lactose and magnesium stear).

target parameter

The duration of the studies was 60 days, with subjective parameters being measured at the beginning of the course, day 30 and day 60. Objective parameters were assessed at the beginning of the course and day 60.
The subjective parameters were provided by a symptom fragey questionnaire using an arbitrary scale (0 = never, 1 = occasionally, 2 = light/weak, 3 = moderate, 4 = strong). Comfortable parameters were oral hygiene, cough with expense, shortness of breath in the event of exertion, loss of appetite, impending doom feeling, racing heart, sleep deprivation, irritability, heartburn and fatigue.
Since there is no toxic risk in taking AMLA fruits, the relevant question is not "Why do you take it?". But why not? "
One of the objective parameters were blood pressure; Lipid profile (total cholesterol, triglyceride, high-density-lipoprotein [HDL] cholesterol, lipoprotein low density [LDL] cholesterol); Sober glucose; Lipoprotein a; Highly sensitive C-reactive protein (HSCRP); Blood tile aggregation; Spirometry; EKG;, mito index and chromosome grinder; antioxidant activity (ability to reduce iron (III) in the plasma and MalondiaHyde content); and oxidative stress (8-hydroxy-2-desoxyguanosin).

important knowledge

Using the mean values ​​for the application group analysis, none of the objective parameters achieved statistically significant differences in the placebo group from the Baseline to the end of the study (day 60). However, the EoE intervention group showed significant differences in the mean values ​​from the Baseline to the degree. The most important differences ( p <0.001) were found for HDL cholesterol (37.4 mg/dl compared to 47.0 mg/dl); Cholesterol/HDL ratio (5.16 compared to 3.85); LDL/HDL ratio (3.32 vs. 2.39); Lipoprotein A (31.20 mg/dl compared to 23.13 mg/dl); and platelet aggregation (54.75 % vs. 37.68 %). Clear differences ( p <0.05) were also found for hemoglobin (14.06 mg/dl compared to 14.42 mg/dl); Erythrocyte number (4.68 m/cm³ vs. 4.86 m/cm³); Total cholesterol (192.2 mg/dl compared to 180.5 mg/dl); LDL (124.3 mg/dl compared to 112.6 mg/dl); and HSCRP (3.4 mg/dl compared to 2.9 mg/dl). The middle mitosis index was only significantly improved ( p <0.01) in the intervention group (0.78 + 0.174 vs. 0.32 + 0.08). There were no significant changes in the lung function tests in both groups.

Comment

e Officinalis ( p Emblica ), popularly known as Indian gooseberry, amalika or amla, is a traditional Rasayana herb that is used in Ayurvedic medicine. Rasayana literally means "the path of the juice" or "juice", 1 but the best translation is included in the concept of rejuvenation. Rasayana pegal medicines restore the cell repair and renewal, inhibit stress through free radicals and act as antimutagenous. Rasayana is the maintenance of the vitality and power of body, mind and soul.
The current study complements the evidence that confirms the traditional use of AMLA to maintain health. In this small study there are measurable and significant changes in many cardiovascular risk parameters in just 2 months. While no clinician would approved the continued smoking, the improvement of the blood parameters is an impressive performance despite the continued inhalation of toxins in the study population. The protection of organ systems from toxic compounds is one of the many traditional advantages attributed to AMLA and validated in animal experiments.
This is not the first study to indicate that Amla lowers cholesterol levels. A publication from 2011 found favorable changes in the lipid profiles after 3 weeks of taking 2 or 3 g amla powder. In particular, total cholesterol and triglyceride dropped significantly, while HDL increased and LDL decreased ( p <. 05 for all parameters). An earlier study of uremic patients showed no changes in the lipid profiles. However, there was a reduction in oxidative stress due to the reduction of the circulating 8-ISO Prostaglandin.
There are traditional plants that stay in the dark and can only be found in ethnobotanic texts and distant countries. Then there are those who find their way to our shelves and "legitimize" their traditional use by scientific means. Amla is clearly the latter. A publication from 2012, in which the potential applications were checked based on preclinical evidence, came to the conclusion that " e officinalis has antipyretic, analgesic, antitusive, antatherogenic, adaptogens, cardocrotectives, gastro -protectives, antianemic, antihypercholesterolineemic, wound -healing, Anti-diarrhoic, ant utherosclerotic, hepatoprotective, nephroprotective and neuroprotective properties. ” 6 Several recent overviews describe the components, traditional uses and the current status of the evidence. 7-10 While the traditional and preclinical evidence clearly matches sparse clinical result Use of Amla.
Since the data from clinical studies get traditional knowledge, it seems that the use of this highly valued fruit in whole, dried or extract form can be helpful for anyone who wants to receive optimal health. This pilot study suggests that people with hypercholesterolemia or ongoing exposure to toxins could be particularly suitable for the health benefits. Since there is no toxic risk when taking AMLA fruits, the relevant question is not "Why do you take it?". But why not? "

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