Study: grape juice improves driving in stressed professional mothers

Veröffentlicht:

Von:

Reference Lamport DJ, Lawton Cl, Merat n, et al. Concord grape juice, cognitive function and mileage: a 12-week, placebo-controlled, randomized crossover study for mothers of children of teenage. Am jlin nutr. 2016; 103 (3): 775-783. Design This 12-week randomized crossover study with a 4-week Washout measure whether the consumption of Concord grape juice (CGJ) improved the cognitive function, measured by mileage in women that were exposed to moderate chronic stress. The participants were assigned 1 of 2 arrangements (CGJ then placebo or placebo then CGJ) according to a balanced randomization plan created by an independent statistician. Participants 25 healthy mothers (at the age of 40-50 years) of children of teenagers who ...
(Symbolbild/natur.wiki)

Reference

lamport DJ, Lawton Cl, Merat n, et al. Concord grape juice, cognitive function and mileage: a 12-week, placebo-controlled, randomized crossover study for mothers of children of teenage. am j clin nutr . 2016; 103 (3): 775-783.

Design

This 12-week randomized crossover study with a 4-week Washout measure whether the consumption of Concord grape juice (CGJ) improved the cognitive function, measured by mileage in women that were exposed to moderate chronic stress. The participants were assigned 1 of 2 arrangements (CGJ then placebo or placebo then CGJ) according to a balanced randomization plan created by an independent statistician.

participant

25 healthy mothers (at the age of 40-50 years) of children of teenage who were employed ≥ 30 hours a week.

medication and dosage study

The participants consumed 12 ounces (355 ml) Concord grape juice (CGJ) (with a total of 777 mg polyphenols) or a placebo.

target parameter

The verbal and spatial memory, executive function, attention, blood pressure and the mood were evaluated at the beginning of the course and after 6 and 12 weeks. Immediately after the cognitive battery, a partial sample of 17 women completed a driving performance assessment at the driving simulator of the University of Leeds. At the 25-minute driving task, the participants had to achieve the speed and direction of a guide vehicle.
The advantages also seemed to stop when the study participants no longer drank grape juice.

important knowledge

Significant improvements in the immediate spatial memory and mileage were observed in accordance with CGJ compared to placebo. There were indications of a persistent effect of CGJ, so that participants who first received CGJ followed by placebo maintain better performance in the placebo arm.

practice implications

While previous investigations indicated that long -term consumption of grape juice gave adults with cognitive impairments, this study suggests that a significant benefit can be measured in everyday tasks such as driving in healthy but stressed people.
The advantages also seemed to stop during the study The participants no longer drank grape juice.
The consumption of food that is rich in polyphenols, such as blueberries, chocolate and grape juice, is associated in clinical studies in humans with an improved cognitive function. Ephraim Bull developed the Concord grape in 1849 in Concord, Massachusetts. The grape and in particular their juice are excellent sources for polyphenols, especially pro-anthocyanidins and anthocyanes. These flavonoids are associated with an improved cognitive function, which is the result of both reduced neuro-inflammation as well as increased neurogenesis and synaptic plasticity. 2.3 three- and four-month studies with older adults who suffered from cognitive problems show that drinking CJC memory improved. 4.5
studies in which blueberries were fed on rats suggest that these advantages are the result of are increased activation of cyclical adenosine monophosphate (camp) binding protein, which leads to an increase in the neurotrophen factor in hippocampus. Blueberries improved the spatial memory in the rats. 6 The consumption of cocoa flavonoids was associated in humans with improved cerebral blood circulation, an effect that is probably the result of increased nitrogen oxide effect. Prefrontal and upper parietal cortical regions increased in both healthy and cognitively impaired adults. 7 Concord grapes is also associated with an improvement in cardiovascular diseases, since it improves the endothelium and nitrogen oxide function.
In 1993
mcewen and Stellar described the allostatic stress model to explain how environmental factors and "genetic predisposition lead to great individual differences in susceptibility to stress and in some cases for diseases".
cognitive impairment is often explained by the use of this allostatic stress model; Chronic stress, cardiovascular diseases and other risk factors trigger a cascade of physiological and psychological consequences, which also includes reduced cognitive performance.
Therefore, the authors of this current study put the hypothesis that people with a higher level of daily stress could benefit from the effects of high -dose polyphenols at CGJ. Such an advantage had already been proven in female rats.
The choice of working women with young children as study participants could either be perceived as amusing or maybe as insulting.
While the cognitive tests carried out on these women provided objective quantitative measurements, it is the test of driving ability that is most insightful and easiest to understand.
driving is a complex ability that requires many different cognitive functions to interact smoothly and quickly. No wonder that stressed people make more driving mistakes. 13 The finding that drinking grape juice significantly influences both the cognitive function and the mileage is logical but still impressive.
The drinking of CJC was associated with statistically significant improvements in verbal memory, spatial memory, psychomotor skills and executive function. These reviews also show that the participants were much more satisfied, more alert and less stressed during the CGJ phase of the study. The results of the mileage tests improved significantly during ARM 1 of the study, but interestingly were just as dramatic during ARM 2 when the participants received placebo instead of CGJ. Although a month had passed, the functional improvement associated with the drinking of grape juice. This effect was larger than expected, and in future studies with a crossover design, the washing-out period should be extended further.
patients often fall in love with exotic fruit juices that are imported from distant countries, and willingly pay considerable sums of money to acquire them, in the hope of improving their health. This present study and other studies on ordinary American Concord grape juice show its significant benefits. If it is our goal to promote the well -being of our patients, we should encourage them to choose ordinary grape juice instead of juices from more exotic areas, at least until ordinary grape juice turns out to be inferior.

  1. Lamport DJ, Dye L, Wightman JD, Lawton Cl. The effects of the consumption of flavonoids and other polyphenols on cognitive performance: a systematic research overview of experimental and epidemiological studies in humans. j nutr Health aging . 2012; 1: 5-25.
  2. Spencer JPE, Vafiadou K, Williams RJ, Vauzour D. Neuroinflammation: Modulation by flavonoids and mechanisms of action. mol aspects med . 2012; 33: 83-97.
  3. Spencer JPE. Beyond antioxidants: the cellular and molecular interactions of flavonoids and how they underpin their effect on the brain. Proc Nutr Soc . 2010; 69: 244-260.
  4. Krikorian R., Nash Ta, Shidler MD, Shukitt-Halle B., Joseph yes. The addition with Concord grape juice improves memory function in older adults with a slight cognitive impairment. br j Nutr . 2010; 103: 730-734.
  5. krikorian r, Boespflug el, Fleck de, et al. Concord grade juice supplement and neurocognitive function in human aging. j agricultural food chem . 2012; 60 (57): 36-42.
  6. Williams cm, el Mohsen Ma, Vauzour d, et al. Blueberer-induced changes in spatial work memory correlate with changes in CREB phosphorylation and the BDNF level in the hippocampus. Free radical Biol Med . 2008; 45: 295-305.
  7. Francis St, Head of K, Morris PG, MacDonald IA. The effect of flavanol-rich cocoa on the FMRI reaction on a cognitive task in healthy young people. j cardiovasc pharmacol . 2006; 47: S215-220.
  8. fisher nd, Hollenberg NK. Age and vascular reactions to flavanol -rich cocoa. j hypertens . 2006; 24: 1575-1580.
  9. Wightman JD, Heuberger Ra. Effect of grapes and other berries on cardiovascular health. J Sci Food Agric . 2015; 8: 1584-1597.
  10. mcewen BS, Stellar E. Stress and the individual. Mechanisms that lead to diseases. Arch Intern Med . 1993; 153 (18): 2093-2101.
  11. Juster RP, McEwen BS, Lupien SJ. Allostatic stress biomarkers for chronic stress and effects on health and cognition. neurosci biobehav rev . 2010; 35: 2-16.
  12. Patki G, Allam FH, Atroz f, et al. The intake of grape powder prevents female gistar rats caused by overiectomy caused fear behavior, memory disorders and high blood pressure. plus one . 2013; 8: E74522.
  13. Matthews G, Sparkes TJ, Bygrave Hm. Stress, attention overload and simulated mileage. carry out . 1996; 9: 77-101.