Study: Nutrating for the supportive treatment of depression

Sarris J., Murphy J., Mischoulon D., et al. Supplementary nutrials for depression: a systematic review and meta -analyzes. am J Psychiatry. 2016; 173 (6): 575-587.

This study was a systematic search in several databases, including Pubmed, Cinahl, Cochrane Library and Web of Science. Clinical studies were included in people who identified both specific nutrotquarters and the type of study. The NUTRAZTika sought included omega-3 fatty acids, folic acid, vitamin D and methyl folks. Due to their reputation, these nutrials were selected as supporting for the brain and neurological function.

In combination, the terms "depression", "major depression", "Major Depression", "Mood", "Antidepressant" and "SSRI" together with "Adjunct", "Adjunctive", "adjuvant", "Augmentation," and "Addition". The studies had to have a treatment period of at least 3 weeks. From an initial search of 5,287 articles, 40 studies met the complete inclusion criteria. Of the 40 studies reviewed for this study, 31 randomized, double -blind and placebo -controlled studies were.

The test subjects of these clinical studies currently took antidepressants and a serious depressive disorder or persistent depression was diagnosed. Depression has been defined as the current intake of antidepressants and a moderate or above the threshold of depressed symptoms according to a validated scale, such as: B. a value of more than 17 on the Hamilton Depression Rating Scale (Ham-D). The majority of the studies used the DSM-IV criteria for the diagnosis of major depression; 29 studies used the Ham-D; And the remaining studies used other well-known scales such as the Beck Depression Inventory or the Montgomery-Åsberg Depression Rating Scale. The average sample size for these studies was 63, with an average age of 44 years. Almost 70 % of the subjects were female. The study participants took a variety of antidepressants, most frequently SSRIS (e.g. fluoxetine), citalopram and escitalopram.

A total of 68 % of clinical studies found positive effects for the complementary intervention examined. In 6 of the 8 studies omega-3 fatty acids mostly contributed to the positive effect. Positive results have been found for repeated studies in which methyl folks, S-ADDENOSYLMETHITHITIN (seame), vitamin D and omega-3 fatty acids (mainly in eicosapentaenic acid (EPA) or ethyl-epa-shape) were tested. Individual studies showed advantages for creatine monohydrate, folic acid and general amino acid combinations. Studies showed positive trends for zinc, folic acid, vitamin C and tryptophan, but with mixed conclusions. None of the studies reported major side effects, apart from occasional versions of stomach or nausea.

In depressive diseases, modern psychiatry with treatment -resistant patients is challenged. About 70 % of the patients with mild to moderate depression - the population group that prescribes most antidepressants - do not respond to antidepressants. 1 In addition, it is increasingly recognized in the field that complete remission is or is either short -term. The National Institute of Mental Health reports that 25 % of the patients who respond to pharmacotherapy will eventually suffer tachyphylaxis (reduced response) during treatment.

Against this background, augmentation strategies in depression treatment must be considered for optimal antidepressant treatment. While the focus in conventional treatment is either on the alternation of medication or the prescription of additional medication, natural remedies can be another option. A number of research begin to rate natural drugs as helpful, and even modern psychiatry has created a consensus to look at nutrotquosives more seriously. ^{3 This paper checked numerous studies and selected studies that adhered to strict standards of conventional medical paradigms.}