Study: Nigella Sativa supports healing in Hashimoto thyroiditis

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Cover Farhangi Ma, Dehghan P., Tajmiri S., Abbasi mm. The effects of Nigella Sativa on the thyroid function, the vascular endothelial growth factor in serum (VEGF) -1, Nesfatin-1 and anthropometric features in patients with Hashimoto-thyroiditis: a randomized study. BMC complement aging med. 2016; 16: 471. Design double-blind, placebo-controlled study participants forty participants aged 22 to 50 years with Hashimoto thyroiditis; 85 % were women. All patients were treated 6 weeks before participating until the end of the study with a stable levothyroxine dose. Initially, 47 participants were included in the study; 4 In the control group, however, refused to continue the attempt, and 3 in ...
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reference

Farhangi Ma, Dehghan P., Tajmiri S., Abbasi mm. The effects of nigella sativa on the thyroid function, the vascular endothelial growth factor in serum (VEGF) -1, nesfatin-1 and anthropometric characteristics in patients with hashimoto thyroiditis: a randomized controlled Study. bmc complement aging med . 2016; 16: 471.

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double-blind, placebo-controlled study

participant

forty participants aged 22 to 50 years with Hashimoto thyroiditis; 85 % were women. All patients were treated 6 weeks before participating until the end of the study with a stable levothyroxine dose. Initially, 47 participants were included in the study; 4 In the control group, however, refused to continue the attempt, and 3 in the nigella group broke down due to itching and nausea.

participants were excluded if they were pregnant or breastfeeding; Had other thyroid anomalies or thyroid surgery in the history; Or have taken other nutritional supplements or a certain diet program 3 months before or during the study.

study parameters evaluated

The participants were randomized in 2 groups; The test group received 1 gram of encapsulated mass nigella sativa seeds and the placebo group received similar capsules with pure strength. Capsules (possibly nigella or placebo) were taken twice a day for 8 weeks.

Primary result measurements

anthropometric dimensions

body weight, body mass index (BMI), waist circumference (toilet), hip circumference (HC) and Waist-to-hip ratio (WHR). The nutritional records were analyzed at the beginning and end of the study to determine whether the calorie and nutrient supply would change.

Biochemical measures

Serum concentrations of thyroid stimulating hormone (TSH), triiodthyronine (T3), thyroxine (T4), antibodies against the thyroid peroxidase (TPO), vascular endothelial growth factor (VEGF), Nesfatin-1.

important knowledge

After 8 weeks of treatment, participants in the nigella group saw a significant reduction of all anthropometric values, while there was no significant change in the placebo group. The calorie or nutrient absorption between the beginning and end of the study did not change significantly in any group.

After 8 weeks of treatment, the participants of the Nigella Group saw a significant reduction in all anthropometric values.

The participants of the Nigella Group also saw a total reduction of the serum-TSH (from 6.42 ± 3.86 to 4.13 ± 2.35, p = 0.03) and anti-TPO antibodies (from 294.55 ± 210.99 ± 158.33, p = 0.019) The T3 mirror. The concentrations of VEGF also decreased overall and it was found that they were dependent on changes in the WHR. No significant change in the Nesfatin 1 level was found in both groups.

practice implications

As a holistic provider, I often see patients in practice who are looking for treatments to fix the basic cause of their autoimmune thyroid disease. As we all know, triggering factors in autoimmune diseases can be variable and difficult to locate, and the process of their identification and correction will be very individual. In addition to the thyroid hormone replacement therapy, the holistic treatment of autoimmune thyroid problems is often multifactorial and can address nutrition and lifestyle factors and use natural therapies to support the thyroid and reduce the inflammatory process. Against this background, the present study presents plant medicine that can help reduce the inflammatory process while helping to eliminate all other obstacles to healing.

nigella sativa is a one -year flower in the family of the cockfoot family with a number of used names, including black cumin, onion seeds and black cumin. It has been used as a culinary spice and medicine in Asia and the Middle East for thousands of years. It is mentioned in the Bible and there is an Islamic belief that it can prevent any illness apart from death. In the past 2 decades, many studies have been carried out that have shown nigella sativa can have a large number of diseases, although the current study seems to be the first to be examined nigellas Effects on Hashimoto-thyroiditis.

The primary active ingredient isolated from nigella sativa is thymochinon. It has been shown that thymochinone in many contexts and clinical pictures, including cancer, diabetes, hyperlipidemia, allergies and other autoimmune diseases, acts as strong antioxidants and anti-inflammatory. Damage. 10.11 In view of these effects in the body, it makes sense to consider the therapeutic potential of this plant in autoimmune diseases of the thyroid.

The antioxidant and anti -inflammatory effects of nigella sativa seem to have contributed to the positive result of this study via some proposed mechanisms. One of them is an increased lipolysis and a reduced lipogenesis due to a acceptance of the VEGF: Several studies have shown that thymochinon lowers the VEGF mirror. 12.13 Increased VEGF has been found in people with chronic thyroiditis and thyroid cancer, and increased TSH levels increase the production of Vegf. 14.15 The vascular endothelial growth factor is also associated with the metabolic syndrome and obesity, since it expands the vascular system to the adipose tissue. The authors of this study postulate that by reducing VEGF, blood supply to the thyroid gland and the adipose tissue also decreases, which leads to a reduction in inflammation in the thyroid gland and a reduction in fat storage.

It was also shown that thymochinone increases heme oxygenase, particularly in inflammation, especially in the vascular endothel. leads.

in the aluminum, nigella has a low toxicity and was described as well tolerated. However, there are case reports that some people don't digest it well. Also remember that 3 people from the treatment group (n = 23) leave because they developed a rash; 13 % is a fairly large proportion of test subjects that show signs of sensitivity, and there were other reports of hypersensitivity reactions to topical application nigella sativa Applications.

clinical, nigella sativa could be a sensible addition to the holistic treatment of Hashimoto thyroiditis. It reduces inflammation, helps to lower TSH and anti-TPO and increases T3. It also helps to reverse part of the weight gain associated with hypothyroidism. It can be used as a strong element of a holistic approach to restore an optimal state of health of the endocrine system and the immune system.

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