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Study: Nigella sativa supports healing in Hashimoto's thyroiditis

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Reference Farhangi MA, Dehghan P, Tajmiri S, Abbasi MM. The effects of Nigella sativa on thyroid function, serum vascular endothelial growth factor (VEGF)-1, nesfatin-1 and anthropometric characteristics in patients with Hashimoto's thyroiditis: a randomized controlled trial. BMC Complement Altern Med. 2016;16:471. Design Double-blind, placebo-controlled study Participants Forty participants aged 22 to 50 years with Hashimoto's thyroiditis; 85% were women. All patients were treated with a stable dose of levothyroxine from 6 weeks before participation until the end of the study. Initially, 47 participants were included in the study; However, 4 in the control group refused to continue the experiment, and 3 in...

Bezug Farhangi MA, Dehghan P., Tajmiri S., Abbasi MM. Die Auswirkungen von Nigella sativa auf die Schilddrüsenfunktion, den vaskulären endothelialen Wachstumsfaktor im Serum (VEGF)-1, Nesfatin-1 und anthropometrische Merkmale bei Patienten mit Hashimoto-Thyreoiditis: eine randomisierte kontrollierte Studie. BMC Komplement Altern Med. 2016;16:471. Entwurf Doppelblinde, Placebo-kontrollierte Studie Teilnehmer Vierzig Teilnehmer im Alter von 22 bis 50 Jahren mit Hashimoto-Thyreoiditis; 85 % waren Frauen. Alle Patienten wurden 6 Wochen vor der Teilnahme bis zum Ende der Studie mit einer stabilen Levothyroxin-Dosis behandelt. Anfänglich wurden 47 Teilnehmer in die Studie eingeschlossen; 4 in der Kontrollgruppe weigerten sich jedoch, den Versuch fortzusetzen, und 3 in …
Reference Farhangi MA, Dehghan P, Tajmiri S, Abbasi MM. The effects of Nigella sativa on thyroid function, serum vascular endothelial growth factor (VEGF)-1, nesfatin-1 and anthropometric characteristics in patients with Hashimoto's thyroiditis: a randomized controlled trial. BMC Complement Altern Med. 2016;16:471. Design Double-blind, placebo-controlled study Participants Forty participants aged 22 to 50 years with Hashimoto's thyroiditis; 85% were women. All patients were treated with a stable dose of levothyroxine from 6 weeks before participation until the end of the study. Initially, 47 participants were included in the study; However, 4 in the control group refused to continue the experiment, and 3 in...

Relation

Farhangi MA, Dehghan P, Tajmiri S, Abbasi MM. The effects of Nigella sativa on thyroid function, serum vascular endothelial growth factor (VEGF)-1, nesfatin-1 and anthropometric characteristics in patients with Hashimoto's thyroiditis: a randomized controlled trial.BMC Complement Aging Med. 2016;16:471.

Draft

Double-blind, placebo-controlled study

Participant

Forty participants aged 22 to 50 years with Hashimoto's thyroiditis; 85% were women. All patients were treated with a stable dose of levothyroxine from 6 weeks before participation until the end of the study. Initially, 47 participants were included in the study; However, 4 in the control group refused to continue the experiment and 3 in theNigellaGroup dropped out due to itching and nausea.

Participants were excluded if they were pregnant or breastfeeding; had other thyroid abnormalities or a history of thyroid surgery; or have taken other nutritional supplements or a specific diet program for 3 months before or during the study.

Study parameters assessed

Participants were randomized into 2 groups; the test group received 1 gram of encapsulated massNigella sativaSeeds and the placebo group received similar pure starch capsules. capsules (possiblyNigellaor placebo) were taken twice daily for 8 weeks.

Primary outcome measures

Anthropometric measurements

Body weight, body mass index (BMI), waist circumference (WC), hip circumference (HC) and waist-to-hip ratio (WHR). Diet records were analyzed at the beginning and end of the study to determine whether calorie and nutrient intakes would change.

Biochemical measures

Serum concentrations of thyroid stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), antibodies to thyroid peroxidase (TPO), vascular endothelial growth factor (VEGF), nesfatin-1.

Key insights

After 8 weeks of treatment, participants in theNigellagroup saw a significant reduction in all anthropometric values, while no significant change was seen in the placebo group. Calorie or nutrient intake between the start and end of the study did not change significantly in any group.

After 8 weeks of treatment, participants in the Nigella group saw a significant reduction in all anthropometric values.

Participants in the Nigella group also saw an overall reduction in serum TSH (from 6.42 ± 3.86 to 4.13 ± 2.35,P= 0.03) and anti-TPO antibodies (from 294.55 ± 210.05 to 147.99 ± 158.33,P=0.019) and an increase in T3 levels. Concentrations of VEGF also decreased overall and were found to be dependent on changes in WHR. No significant change in nesfatin-1 levels was detected in either group.

Practice implications

As a holistic provider, I often see patients in the office seeking treatments to address the root cause of their autoimmune thyroid disease. As we all know, precipitating factors in autoimmune diseases can be variable and difficult to pinpoint, and the process of identifying and correcting them will be very individual. In addition to thyroid hormone replacement therapy, holistic treatment for autoimmune thyroid problems is often multifactorial and may address nutritional and lifestyle factors and utilize natural therapies to support the thyroid and reduce the inflammatory process. With this in mind, the present study presents a plant medicine that can help reduce the inflammatory process while helping to remove any other obstacles to healing.

Nigella sativais an annual flower in the buttercup family with a number of common names including black cumin, onion seed and black cumin. It has been used as a culinary spice and medicine in Asia and the Middle East for thousands of years. It is mentioned in the Bible, and there is an Islamic belief that it can prevent every disease except death. In the last 2 decades, many studies have been carried out that have shownNigella sativamay positively impact a variety of diseases, although the current study appears to be the first to be investigatedNigellaEffects on Hashimoto's thyroiditis.

The primary active ingredient isolates fromNigella sativais thymoquinone. Thymoquinone has been shown to act as a potent antioxidant and anti-inflammatory in many contexts and conditions, including cancer, diabetes, hyperlipidemia, allergies and other autoimmune diseases.1-9In rat studies, thymoquinone showed a protective effect against induced oxidative damage.10,11Given these effects in the body, it makes sense to consider the therapeutic potential of this plant in autoimmune thyroid diseases.

The antioxidant and anti-inflammatory effects ofNigella sativaappear to have contributed to the positive outcome of this study through some proposed mechanisms. One of these is increased lipolysis and decreased lipogenesis resulting from a decrease in VEGF: several studies have shown that thymoquinone reduces VEGF levels.12,13Elevated VEGF has been found in people with chronic thyroiditis and thyroid cancer, and increased TSH levels increase the production of VEGF.14.15Vascular endothelial growth factor is also associated with metabolic syndrome and obesity because it dilates the vasculature to fatty tissue. The authors of this study postulate that by reducing VEGF, blood supply to the thyroid and adipose tissue also decreases, leading to a reduction in inflammation in the thyroid and a reduction in fat stores.

Thymoquinone has also been shown to increase heme oxygenase, which reduces inflammation, particularly in the vascular endothelium.16,17Increased heme oxygenase is another proposed mechanism in this study for reduced inflammation in the thyroid, leading to reduced anti-TPO antibodies and increased T3 levels.

In general,Nigellahas low toxicity and has been described as well tolerated. However, there are case reports that some people do not digest it well. Also remember that 3 people dropped out of the treatment group (n = 23) because they developed a rash; 13% is a fairly large proportion of subjects showing signs of sensitivity, and there have been other reports of hypersensitivity reactions to topical applicationNigella sativaApplications.18.19When using this plant, it would be advisable to tell patients to watch for signs of hypersensitivity.

clinical,Nigella sativacould be a useful addition to the holistic treatment of Hashimoto's thyroiditis. It reduces inflammation, helps lower TSH and anti-TPO, and increases T3. It also helps reverse some of the weight gain associated with hypothyroidism. It can be used as a powerful element of a holistic approach to restoring the endocrine and immune systems to optimal health.

  1. Khader M, Eckl PM. Thymochinon: ein aufstrebendes natürliches Medikament mit einem breiten Spektrum an medizinischen Anwendungen. Iran J Basic Med Sci. 2014;17(12):950-957.
  2. Majdalawieh AF, Fayyad MW. Immunmodulatorische und entzündungshemmende Wirkung von Nigella sativa und Thymochinon: Eine umfassende Übersicht. Int. Immunopharmacol. 2015;28(1):295-304.
  3. Darakhshan S., Bidmeshki Pour A., ​​Hosseinzadeh Colagar A. et al. Thymochinon und seine therapeutischen Möglichkeiten. Pharmakol. Res. 2015;95–96:138–158.
  4. Gholamnezhad Z, Havakhah S, Boskabady MH. Präklinische und klinische Wirkungen von Nigella sativa und seinem Bestandteil Thymochinon: eine Übersicht. J Ethnopharmacol. 2016;190:372-386.
  5. Sabzghabaee AM, Dianatkhah M, Sarrafzadegan N, et al. Klinische Bewertung von Nigella sativa-Samen zur Behandlung von Hyperlipidämie: eine randomisierte, Placebo-kontrollierte klinische Studie. Med Arh. 2012;66(3):198-200.
  6. Gheita TA, Kenawy SA. Wirksamkeit von Nigella sativa-Öl bei der Behandlung von Patienten mit rheumatoider Arthritis: eine Placebo-kontrollierte Studie. Phytother-Res. 2012;26(8):1246-1248.
  7. Işik H, Cevikbaş A, Gürer US, et al. Mögliche adjuvante Wirkungen von Nigella sativa-Samen zur Verbesserung der spezifischen Immuntherapie bei Patienten mit allergischer Rhinitis. Med Princ Pract. 2010;19(3):206-211.
  8. Ahmed A., Husain A., Mujeeb M. et al. Eine Übersicht über das therapeutische Potenzial von Nigella sativa: ein Wunderkraut. Asian Pac J Trop Biomed. 2013;3(5):337-352.
  9. Salem, ML. Übersicht: Immunmodulatorische und therapeutische Eigenschaften des Nigella sativa L.-Samens. Int. Immunopharmacol. 2005; 5(13-14):1749-1770.
  10. Kanter, M., Coskun, O., Korkmaz, A., et al. Auswirkungen von Nigella sativa auf oxidativen Stress und Beta-Zell-Schäden bei Streptozotocin-induzierten diabetischen Ratten. Anat Rec A Discov Mol Cell Evol Biol. 2004; 279(1):685-691.
  11. Kanter, M., Demir, H., Karakaya, C., et al. Gastroprotektive Aktivität von Nigella sativa L-Öl und seinem Bestandteil Thymochinon gegen akute alkoholinduzierte Schädigung der Magenschleimhaut bei Ratten. Welt J Gastroenterol. 2005;11(42):6662-6666.
  12. Zhang L, Bai Y, Yang Y. Thymochinon chemosensibilisiert Dickdarmkrebszellen durch Hemmung von NF-κB. Oncol Lett. 2016;12(4):2840-2845.
  13. Al-Trad B, Al-Batayneh K, El-Mwally S, et al. Nigella sativa-Öl und Thymochinon verbessern die Albuminurie und die Akkumulation der extrazellulären Matrix in den experimentellen diabetischen Ratten. Eur. Rev. Med. Pharmacol. Sci. 2016;20(12):2680-2688.
  14. Klein M, Picard E, Vignaud JM, et al. Gen und Protein des vaskulären endothelialen Wachstumsfaktors: starke Expression bei Thyreoiditis und Schilddrüsenkarzinom. J Endocrinol. 1999;161(1):41-49.
  15. Soh EY, Sobhi SA, Wong MG, et al. Schilddrüsen-stimulierendes Hormon fördert die Sekretion des vaskulären endothelialen Wachstumsfaktors in Schilddrüsenkrebs-Zelllinien. Chirurgie. 1996;120(6):944-947.
  16. Calay D, Mason JC. Die multifunktionale Rolle und das therapeutische Potenzial von HO-1 im vaskulären Endothel. Antioxid-Redox-Signal. 2014;20(11):1789-1809.
  17. Kundu J, Kim DH, Kundu JK, et al. Thymochinon induziert Hämoxygenase-1-Expression in HaCaT-Zellen über Nrf2/ARE-Aktivierung: Akt und AMPKα als vorgeschaltete Ziele. Food Chem Toxicol. 2014;65:18-26.
  18. Gelot P, Bara-Passot C, Gimenez-Arnau E, et al. Bullöser Drogenausschlag mit Nigella sativa-Öl. Ann Dermatol Venereol. 2012;139(4):287-291.
  19. Zaoui A., Cherrah Y., Mahassini N., et al. Akute und chronische Toxizität von Nigella sativa-fettem Öl. Phytomedizin. 2002;9(1):69-74.

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