Study: marijuana in the treatment of diabetes
Study: marijuana in the treatment of diabetes
Reference
Penner EA, Buettner H, Mittleman Ma. The effects of marijuana consumption on glucose, insulin and insulin resistance in adults in the USA. am j med . 2013; 126 (7): 583-589.
Design
Data collected as part of the cross-sectional survey of the National Health and Nutrition Examination Survey (Nhanes) from 2005 to 2010 were examined in order to get the connection between regular marijuana consum and the measurement of sober glucose and insulin levels, insulin resistance, blood pressure, body mass index, waist and high-quality circumference Lipoprotein cholesterol. Blood samples were removed after a 9-hour fasting. The consumption of marijuana was reported in a private space.
participant
4,657 men and women aged 20 to 59 took part in the study; 578 were current marijuana consumers and 1,975 were former consumers.
primary result dimensions
Natural glucose and insulin levels, insulin resistance (Homa-IR), blood pressure, body mass index (BMI), waist size and high-density-lipoprotein cholesterol
study parameters
From 2005 to 2010, 11,335 subjects aged 20 to 59 took part in the Nhanes survey on illegal drug use. The data was reported in a private space itself. Of these, 4,657 also provided sober blood samples that were used to calculate these values.
most important knowledge
Early and current marijuana consumption was associated with lower sober insulin, glucose, homa-ir, BMI and waist scale values.
Comment
The medical use of marijuana disappeared almost completely at the beginning of the 20th century. by marijuana in the 1960s and 1970s quickly. 2.3 The Marihuana Tax was replaced by the Controlled Substance Act from 1970, which categorized marijuana as a substance that "currently has no recognized medical use", "has a high lack of abuse" and "a lack of data to be recognized" has the use of the drug ”. Substance under medical supervision. " Marijuana was classified in the strictest category for prescription drugs, Appendix I.
The active molecules of marijuana, the cannabinoids, were isolated in the early 1960s and the first cannabinoid receptor (CB1) was identified in 1988. 5 Soon another cannabinoid receptor (CB2) was discovered, and the discovery of endocannabinoids followed Affect these receptors. These discoveries made preclinical research into the activities of cannabinoids in the various diseases in which marijuana was used therapeutically. Clinical research was still disabled by federal laws and regulations. partly based on the connection between marijuana with the appetite stimulation began to examine the substance and their effects on calorie consumption and metabolism. Researchers discovered a paradox: marijuanara naucers have more calories than non-consumers, but are less likely to suffer from obesity. 6–8 Investigations with diabetes mouse models showed that the most common in marijuana, Delta-9-tetrahydrocannibinol (THC) and cannabidiol (CBD), the severity or outbreak of the disease. 9.10 In another study it was found that a cannabis extract significantly protected the insulin -producing pancreatic cells of rats from the harmful effects of grease loop.
Due to the special hurdles that exist in the research of the advantages of cannabis in humans, another data source must be used to confirm the trends observed in animals or animals in vitro models. Large epidemiological studies can provide clues that strengthen or weaken preclinical observations. Data from the National Health and Nutrition Examination Survey (Nhanes) of 4,657 participants showed that "marijuana consumer was associated with a reduced prevalence of diabetes mellitus". 12 The current study takes a closer look at the Nhanes data to take the paradox of increased calorie Weight and a lower diabetes incidence, better understand. The researchers used values for sober serum insulin and sober-plasmaglukose to calculate the homeostasis model assessment of insulin resistance (Homa-IR), an indicator of insulin resistance. They found that regular, monthly marijuana consumers showed significantly lower sober insulin, glucose, homa-ir values and waist circumference than never consumers. The frequent marijuanares also had higher values of high-density lipoprotein cholesterol (HDL-C), a marker for heart health. Nevertheless, it is unlikely that smoking marijuana will be widely promoted due to its health benefits, which is partly due to the harmful effects of the harmful by -products of combustion. However, cannabis was often used in the form of tinctures or pills before the Marihuana Tax Act was adopted. This type of Administration could also dispel concerns about undesirable consciousness -changing effects. The Cannabinoid CBD reduces the psychoactive effect of THC; Therefore, taking a combined cannabinoid medium could offer health benefits without cognitive effects. 13 The protection dose can also be much lower than psychoactive dose. Researchers in Israel found that an extremely low THC dose that is three to four orders of magnitude under a psychoactive dose offers significant protection for the heart, brain and liver against ischemic damage.
The potentially significant advantages of a low -risk but illegal cannabis consumption bring the committed doctor into an unpleasant situation, even in countries in which marijuana is medically operated. The freedom of a doctor to inform patients about the advantages of cannabis was determined by a case of the Supreme Court, but there is little clarification of the medical use of cannabis. Due to the lack of knowledge and a lack of published evidence base, many doctors hesitate to recommend cannabis to their patients as medicinal products or to discuss it with them at all. The difficulties in implementing clinical research to evaluate the potential medical benefit of cannabis have already been mentioned and cannot be emphasized enough. 16 The number of official hurdles that a researcher has to overcome in order to obtain all permits required for the examination of cannabis can be discouraging. What clinical implications then does this Nhanes data analysis have? Can cannabis consumption reduce diabetes, insulin resistance and obesity? Can diabetic cannabis add as an addition to your blood sugar -lowering means to achieve synergistic advantages? We are aware that the plural of "Anecdote" is not a proof, and therefore report on the effects of a cannabis extract on the diabetes treatment of a personal friend. This 50-year-old woman is an insulin-dependent diabetic who, despite a normal body mass index, had difficulties with blood sugar control. She added a daily dose of a cannabis extract to her insulinur. She reports that her blood sugar level is much better under control and has dropped 90 to 100 points after taking it. This individual anecdote in connection with the strength of the Nhanes results suggests that further research is necessary. We applaud Dr. Alpert, editor -in -chief of the American Journal of Medicine who demands the cooperation between the National Institutes of Health and the Drug Enforcement Administration to facilitate the development of scientific studies and provide doctors the data they need to "use and prescribe THC in its synthetic or herbal form" Support.