Study: Maitake triggers ovulation in people with polycystic ovarian syndrome
Study: Maitake triggers ovulation in people with polycystic ovarian syndrome
The present study deals with examining the effect of a Maitake mushroom extract (Grifola Frondosa) on ovulation in patients with polycystic ovarian syndrome (PCOS). The study was carried out at 80 participants, 72 of whom completed the study. Two groups were formed in the study: the first group received the Maitake mushroom extract and the second group received clomifencitrate, which is usually used to trigger the ovulation. After three menstrual cycles, it was found that the ovulation rate in the Maitake Group was 76.9 % and in the clomifencitrate group at 93.5 %. A combination of the two therapies led to ovulation in all patients who had not asked about individual therapy. The authors suggest that the Maitake mushroom extract increases insulin sensitivity, which leads to regular ovulation cycles. The study shows a promising alternative treatment option for PCOS patients, but further studies are required to confirm the results.
Details of the study:
reference
Chen Jt, Tominaga K, Sato Y, Anzai H, Matsuoka R. Maitake-Mush ( Grifola Frondosa )-extract induces ovulation in patients with polycystic ovary syndrome: Possible monotherapy and a combination therapy after failure with clomifencitrate of the first choice. j an alternate med. 2010; 16 (12): 1295-1299.
study design
open label, no placebo control
participant
eighty subjects with the diagnosis PCOS. The admission was based on the following criteria:
- 18–35 years old
- PCOS diagnosis, displayed by the presence of oligomenorrhea and hyperandrogenism and/or increased basal luteinizing hormone (LH) and normal basal follicle stimulating hormone (FSH), polycystic ovaries, proven by ultrasound
- no diabetes mellitus; And
- no hypercholesterolemia.
After demolition or non -compliance, 72 women took part in the study. Group 1 (n = 36) received the SX faction from Maitake mushrooms (MSX), which contained 250 mg dried mayitake mushroom powder and 18 mg MSX per tablet, in a dose of 3 tablets between meals. Group 2 (n = 36) received 50 mg clomifencitrate (CC) daily on the days 5–9 of the menstrual cycle. The duration of studies included 3 menstrual cycles. Due to dropouts and deviations from the protocol, 12 participants were not included in the ovulation analysis.
most important findings
After 3 menstrual cycles, the MSX group (26 women) had an ovulation rate of 76.9 % and the CC group (31 women) an ovulation rate of 93.5 %. Fifteen subjects who did not respond to CC or MSX were then received a combination therapy from CC and MSX. With this combined therapy there was an ovulation in 100 % of the failed MSX group and in 75 % of the CC group.
Effects on the practice
As a naturopath, most of my PCOS patients come to me because they want alternatives to clomifencitrate and metformin. The basic measures for all PCOS patients include changing insulin regulation through movement and dietary measures that reduce serum glucose level. In addition, many patients may need certain nutrients and herbs to alleviate the effects of hyperandrogenism and hyperinulinemia. Depending on the symptoms, nutrients such as chrome, lipoat, b-vitamins and magnesium as well as herbs such as peony, licorice and saw palm can also be displayed.
The proposed mechanism of action of the SX faction from the Maitake mushroom is to modulate the blood sugar level and to increase insulin sensitivity.
This study by Chen et al. Another possible alternative to improve insulin sensitivity and to trigger the ovulation. The proposed mechanism of action of the SX faction from the Maitake mushroom is to modulate the blood sugar level and increase insulin sensitivity. Women with PCOS by increasing insulin sensitivity and the associated reduction in insulin levels have a lower androgen level and thus regular ovulation cycles. Although the study group was small, it is exciting to have another natural active ingredient that helps our PCOS patients. A clinical disadvantage of MSX may be the required dosage. In this study, women took 3 capsules three times a day for 3 months. No side effects were reported, with the exception of a slight epigastralgia, which was found in two women, the MSX income. However, the question arises of costs and compliance. Maitake is naturally an expensive nutritional supplement and was taken daily in this study. In contrast, Clomipen only had to be administered for four days during the follicular phase - much simpler treatment. In reality, the naturopathic treatment of a PCOS patient for the patient is already difficult because the nutritional restrictions to be observed can be a major challenge for many. One wonders whether the addition of 9 tablets a day is feasible in the long term. Nevertheless, Maitake extract is a new natural means that is promising for those patients who decide not to use medicines to trigger the ice. Further studies are required to underpin this small, open study.