Study: flax seeds reduce aggressiveness in prostate cancer

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Referenz Azrad M, Vollmer RT, Madden J, et al. Aus Leinsamen gewonnenes Enterolacton ist umgekehrt mit der Tumorzellproliferation bei Männern mit lokalisiertem Prostatakrebs verbunden. J Med Food. 2013;16(4):357-360. Design Datenextraktion aus einer früheren randomisierten kontrollierten Phase-II-Studie Teilnehmer Die Studie umfasste 161 Männer mit Prostatakrebs, die sich einer Prostatektomie unterzogen, von denen 147 über ausreichende Informationen für eine Analyse verfügten. Studieren Sie Medikamente und Dosierung Die Daten für diese Studie stammen aus einer früheren Studie, in der Männer nach Rasse (Schwarze vs. Nicht-Schwarze) und Gleason-Score (Gleason ≥7 vs ≤6) in 4 Gruppen randomisiert wurden: Kontrolle (n=41), Leinsamen (FS; n=40), fettarme Diät …
Reference Azrad M, Vollmer RT, Madden J, et al. Conversely, tumor cell proliferation in men with localized prostate cancer is associated with flaxseed enterolactone. J med food. 2013; 16 (4): 357-360. Design data extraction from an earlier randomized controlled phase II study participant. The study included 161 men with prostate cancer who underwent a prostate, 147 of which had sufficient information for an analysis. Study medication and dosage The data for this study comes from an earlier study in which men have been randomized to 4 groups to breed (black vs. non-black) and Gleason score (Gleason ≥7 vs ≤6): control (n = 41), linseed (FS; n = 40), low-fat diet ... (Symbolbild/natur.wiki)

Reference

Azrad M, Vollmer RT, Madden J, et al. Conversely, tumor cell proliferation in men with localized prostate cancer is associated with flaxseed enterolactone. j med food. 2013; 16 (4): 357-360.

Design

data extraction from an earlier randomized controlled phase II study

participant

The study included 161 men with prostate cancer who underwent a prostate, 147 of which had sufficient information for an analysis.

study medication and dosage

The data for this study comes from an earlier study in which men came to breed (black vs. non-black) and Gleason score (Gleason ≥7 vs ≤6) in 4 groups: control (n = 41), linseed (FS; n = 40), low-leash diet (Lf; n = 40) or linseed diet (fs & Lf; The flax seed groups consumed 30 g/day and the groups with "low -fat" diet took less than 20 % of the calories a day of fat. For the purposes of the present study, both linseed groups were summarized to the flaxsee group (n = 73) and the control and LF group to the group without flax seeds (n = 74). The nutritional and flaxpint intervention began about 30 days before the prostate.

target parameter

Enterolacton, Enterodiol and total ligner in urine (μg/day) at the start of the course and at the time of the operation. Correlations between urine-enthusiasts and prostate tumor expression of KI-67, vascular endothelial growth factor (VEGF) and core factor Kappa B (NF-κB) were assessed.

most important knowledge

There were significant correlations between the intake of vegetable lignan and the concentrations of the entire enterolignan in urine ( p <0.0001), Enterolactone ( p <0.0001) and Enterodiol ( p <0.0001). Conversely, the total amount of enterolignans and enterolactone in the urine correlated with the KI-67 mirrors in the tumor tissue ( p = 0.011 and p = 0.007). Although statistically not significant, an reverse connection with enterolactone and vegf was observed ( p = 0.141). There was no connection with the lign registration in urine and the NF-κB expression in tumor tissue.

Comment

lignane are a kind of phytoestrogen that occurs in a variety of food, including cabbage vegetables, legumes, seeds and whole grains. Flax seeds have an exceptionally high content, with the Lignan sececoisolariciresinol-diglucoside constitutes about 0.05 to 0.2 percent. Prostate cancer. 2-4 The current study shows that this "protection" can go one step further and reduce the aggressiveness of an existing tumor.
It is striking that a process of illness, the development of which takes many years, is affected by a change of diet only 30 days.
This publication is a continuation of the prior publication of the authors: "A nutritional supplement with flax seeds (no restriction of the food fat) reduces the proliferation rates of prostate cancer." 5 Using the same participant, the authors found that both groups that consumed linseed preparations, a lower proliferation index (Ki-67) showed the control group and the low-fat group. In the current summary, the authors analyzed the same prostate tissue to assess the molecular changes in VEGF and NF-κB. For the statistical analysis, the four groups were divided into only two groups: flax seeds and no flax seeds. In addition to KI-67, VEGF and NF-κB were rated. Here, too, Ki-67 was significantly lower in the flaxsee group. While VEGF expression in the linseed group tends to be lower, there were no changes associated with NF-κB. This indicates that the lower cell proliferation may be due to other factors than VEGF and NF-κB.
How exactly Enterolignanes such as Enterolactone can reduce development and growth of prostate cancer is not well known. An in-vitro study suggests that enterolactone can increase apoptosis in prostate cancer through mitochondrial effect. Growth receptors, an anti -proliferative effect that has been demonstrated in androgen sensitive and androgen -independent prostate nepper lines. be. 9
Of course, linseed in this study was administered as a full -fledged food (just under ¼ C daily), and reducing it to a mere source of enterolignanes is too strong simplification. Another component, alpha-linolenic acid (ALA), is also rich in flax seeds. Epidemiological data on the effects of linolenic acid on the risk and the aggressiveness of prostate cancer are contradictory, so it is not clear whether ALA offers a certain protection through food or whether the trend towards increased risk of prostate cancer is real.
The authors of the current study have brought some light into this inconsistency. Using the same study participant and the same linseed intervention as in the current summary, they assessed the concentrations of ALA, KI-67 and prostate-specific antigen (PSA) in prostate cancer tissue. 6 desaturase is used. They found two surprising results. First, the ala values ​​in the prostate tissue were not higher among those who consumed flax seeds, although they consumed seven times higher ALA values ​​compared to the group without flaxseed. Second: The higher the ala level in the prostate itself, the more aggressive the cancer, measured by KI-67 ( p = 0.058) and the higher the PSA ( p = 0.004). Variants of SNPS in the Delta6Saturasen gene correlated with higher or lower KI-67 mirrors, which indicates that there is a genetic influence on the role of ala in the prostate tissue. This variability could explain the different results of epidemiological studies on ala consumption and prostate cancer.
It takes years, even decades for prostate cancer. It is striking that a process of illness, the development of which lasts many years, is affected by a change of diet that lasts only 30 days. It is a memory that cancer growth is dynamic regardless of the stage and can be influenced by the choice of lifestyle.
Even if this study is small and further prospective studies are required to lead clinical decision -making, flax seeds are also a food and there is hardly or no negative risk if we encourage our patients with prostate cancer to take a generous amount of flax seeds in their diet.

  1. Setchell KD, Brown Nm, Zimmer-Nechemias L, Wolfe B, JHA P, Heubi Je. Metabolism of secoisolariciresinoldiglykoside, the food precursor of the Lignans Enterolacton from the intestine in humans. food function. January 16, 2014. Epub before printing.
  2. Hedelin M, Klint a, Chang et, et al. Food phytootrogen, serum enthuson and prostate cancer risk: the cancer-prostata-Sweden study (Sweden). cancer causes control. 2006; 17 (2): 169-180.
  3. Zamora-Ros R, not C, Guinó e, et al. Connection between the habitual absorption of flavonoids and lignans about food and colon cancer in a Spanish case control study (the Bellvitge-Colorectal Cancer study). cancer causes control. 2013; 24 (3): 549-557.
  4. Suzuki R, Rylander-Rudqvist T, Saji S, Bergkvist L, Adler Creutz H, Wolk A. Food Lignan and Postmenopausal Breast Cancer risk through estrogen receptor status: a prospective cohort study on Swedish women. br j Krebs. 2008; 98 (3): 636-640.
  5. Demark-Wahnefried W, Polascik TJ, George Sl, et al. A nutritional supplement with flax seeds (no restriction of the food fat) reduces the proliferation rate of prostate cancer in men from surgery. cancer epidemiol biomarker beforehand. 2008; 17 (12): 3577-3587.
  6. chen LH, Fang J, Li H, Demark-Wahnefried W, Lin X. Enterolacton induces apoptosis in human prostate carcinoma lncap cells through a mitochondrial, caspase-dependent path. mol cancer Ther. 2007; 6 (9): 2581-2590.
  7. Evans BA, Griffiths K, Morton MS. Inhibition of 5-alpha reductase in genital skin fibroblasts and prostate tissue by dietary lignanes and isoflavonoids. j endocrinol. 1995; 147 (2): 295-302.
  8. chen LH, Fang J, Sun Z, et al. Enterolactone inhibits the signal transmission of the insulin-like growth factor 1 receptor in PC 3 cells of human prostate cancer. j nutr. 2009; 139 (4): 653-659.
  9. McCann MJ, Gill Ci, Linton T, Berrar D, McGlynn H, Rowland IR. Enterolactone limits the proliferation of the human prostate cancer cell line LNCAP in vitro. mol nutr food res. 2008; 52 (5): 567-580.
  10. Brouwer Ia, Katan MB, Zock Pl. Food intake of alpha-linolenic acid is associated with a reduced risk of fatal coronary heart disease, but an increased risk of prostate cancer: a meta-analysis. j nutr. 2004; 134 (4): 919-922.
  11. Simon Ja, Chen Yh, Bent S. The connection between alpha-linolenic acid with the risk of prostate cancer: a systematic review and meta-analysis. Bin J clin nutr. 2009; 89 (5): 1558S-1564S.
  12. Carleton AJ, Sievenpiper JL, de Souza R, McKown-Eyssen G, Jenkins DJ. Case control and prospective studies on the absorption of α-linolenic acid on food and the risk of prostate cancer: a meta-analysis. bmj open. 2013; 3 (5).
  13. Azrad M, Zhang K, Vollmer RT, et al. Prostate alpha-linolenic acid (ALA) is positively associated with aggressive prostate cancer: a connection that may depend on genetic variations in ala metabolism. plus one. 2012; 7 (12): E53104.