Study: Khorasan wheat and type 2 diabetes
![Bezug Whittaker A., Dinu M., Cesari F. et al. Eine auf Khorasan-Weizen basierende Ersatzdiät verbessert das Risikoprofil von Patienten mit Typ-2-Diabetes mellitus (T2DM): eine randomisierte Crossover-Studie [published online ahead of print February 8, 2016]. Eur J von Nutr. doi:10.1007/s00394-016-1168-2. Studienziel Um festzustellen, ob eine Ernährung mit Produkten aus altem Bio-Khorasan-Weizen (Triticum turgidum subsp Turanikum) könnte zusätzliche Schutzwirkungen bei der Reduzierung von Glukose-, Insulin-, Lipid- und Entzündungsrisikofaktoren und bei der Wiederherstellung des Blutredoxgleichgewichts bei Patienten mit Typ-2-Diabetes mellitus (T2DM) im Vergleich zu einer Ernährung mit Produkten aus modernem Bio-Weizen bieten. Design und Teilnehmer Eine randomisierte, doppelblinde Crossover-Studie mit 2 Interventionsphasen an …](https://natur.wiki/cache/images/SIBO-and-Anti-Inflammatories-Boswellia-Curcumin-jpg-webp-1100.webp)
Study: Khorasan wheat and type 2 diabetes
reference
Whittaker A., Dinu M., Cesari F. et al. A replacement diet based on Khorasan wheat improves the risk profile of patients with type 2 diabetes mellitus (T2DM): a randomized crossover study [published online AHead of print February 8, 2016]. EUR J from Nutr . DOI: 10.1007/S00394-016-1168-2.
Study goal
to determine whether a diet with products from old bio-khorasan wheat ( triticum turgidum subsp turanikum ) could additional protective effects in reducing glucose, insulin, lipid and inflammatory risk factors and in the restoration of the blood-rox equal weight in patients with Type-2-diabetes mellitus (T2DM) offer compared to a diet with products from modern organic wheat.
design and participant
A randomized, double-blind crossover study with 2 intervention phases on 21 patients (14 women, 7 men). The volunteers were divided into 2 groups on the random. Each group was asked to consume products (bread, noodles, crackers and cookies) in random order for 8 weeks, which were made from half-full grain flour from organic wheat, which came from either old Khorasan wheat or modern wheat (control). The participants did not know the type of wheat products given to them, but were instructed not to eat other wheat products during the intervention period. They were also told that they should not make significant changes in terms of nutrition, exercise or other habits (such as smoking) during the entire test period. An 8-week wash-up phase was carried out between the interventions. During this time, the volunteers could eat what they wanted. At the beginning and at the end of each intervention, all participants were examined between 7:00 a.m. and 9:30 a.m. after a nightly Lent and blood was taken for analysis. The participants were asked not to exercise strenuous physical activities the day before the examination.
important knowledge
First, the data was analyzed with paired t tests to significant differences between the changes observed at the beginning and after the intervention for each tested variable for every intervention period (test and control diet).
The metabolic risk profile only improved compared to the starting value after the Khorasan wheat intervention period, measured by reducing overall cholesterol (medium reduction -3.7 %; p = 0.047), LDL cholesterol (-3.4 %; p = 0.049), insulin (-16.3 %; p = 0.045) and blood sugar (-9.1 %; p = 0.049). Similarly, there was a significant reduction in the circulating mirror of reactive oxygen species (ROS), vascular endothelial growth factor (VEGF) and interleukin-1 receptor antagonist (IL-1RA) and a significant increase in the entire antioxidant capacity (+6.3 %). ; p = 0.049). After the intervention phase for modern control wheat, no significant differences compared to the initial value were found.
practice implications
The present study is the fourth in a number of published studies that show the health-promoting advantages of organic old Khorasan wheat, advantages that are not obvious in modern organic wheat (control). The studies in this series were designed in a similar way with human volunteers. The first study dealt with the effect of old and modern wheat on cardiovascular risk parameters in healthy subjects. 1 The second study focused on participants with moderate cases of irritable bowel syndrome (IBS). Cardiovascular diseases.
A simple change in the diet of modern to old wheat can improve the health of people suffering from chronic diseases.
Although these studies were small, the results were so consistent that they lend credibility that go beyond what is normally attributed to small studies. In each study, old wheat was associated with a significant decrease in inflammatory markers and a significant increase in antioxidant capacity. Patients with IBs experienced a significant global improvement in the extent and the severity of the symptoms, such as flatulence, bloated stomach, abdominal pain, frequency, tiredness and satisfaction with stool consistency, with a resulting improvement in the quality of life. The cholesterol, blood sugar and insulin levels fell in these patients, while the serumagnnesium increased. Since most chronic diseases are associated with inflammation and the substitution of old grain reduces inflammation, a simple conversion of the diet of modern to old wheat can improve the health of those suffering from chronic diseases.
restrictions
The size of the patient population was small and the study must be carried out on a larger population to verify the results. In addition, blood pressure fluctuations were not taken into account. However, since there were a number of reactions to traditional risk factors for vascular complications in this small T2DM population and, despite this variation, there were significant changes in various parameters, the changes could be attributed to substitution by Khorasan wheat. The body weight did not change significantly during the study, which indicates that the participants adhered to their normal carbohydrate intake and that the advantageous effects were not related to weight loss, but with the type of grain.
FAZIT
A diet with old Khorasan wheat compared to modern wheat offered additional protection in reducing the total and LDL cholesterol, insulin, blood sugar, ROS production and some inflammatory risk factors. All of these are key factors that can help to control or prevent secondary complications based on T2DM.
disclosure of conflicts of interest
The author is the founder of Kamut International and responsible for the introduction of the Khorasan wheat of the old GREIDEMARKE KAMUT® on a global market. The study on which this summary and this comment are based was carried out in Italy by the University of Florence in cooperation with the Careggi University Hospital of Florence and sponsored by the Kamut® project.
- Sofi f, Whittaker A, Cesari f, et al. Characterization of Khorasan wheat (Kamut) and the influence of a replacement diet on cardiovascular risk factors: cross-over nutrition intervention study. EUR J Clin Nutr . 2013; 67 (2): 190-195.
- Sofi F., Whittaker A., Gori Am, et al. Effect of triticum turgidum subsp. Turanicum wheat in irritable bowel syndrome: a double-blind, randomized dietary intervention study. br j Nutr . 2014; 111 (11): 1992-1999.
- Whittaker A., Sofi F., Luisi Ml, et al. An organic replacement diet on Khorasan wheat-based improves the risk profile of patients with acute coronary syndrome: a randomized crossover study. nutrients . 2015; 7 (5): 3401-3415.