Study: Can laughter therapy reduce radiation matis?
Study: Can laughter therapy reduce radiation matis?
Reference
Kong M, Shin Sh, Lee E, Yun Ek. The effect of laughing therapy on radiation matis in patients with breast cancer: a simply blinded prospective pilot study. onco targets Ther. 4. November 2014; 7: 2053-2059.
Design
prospective, randomized controlled clinical study
participant
37 patients were prospectively included in this study. The selection criteria included a pathologically confirmed one -sided breast cancer without tumor invasion of the skin, the conclusion of a breast -preserving operation with or without adjuvant chemotherapy and treatment with postoperative radiation therapy of at least 45 gray. Eighteen patients were assigned to the test group and the other 19 patients were assigned to the control group. The patients in the test group received laughter therapy during radiation therapy. The laughing therapy began at the beginning of the therapy and carried out twice a week until the end of the treatment. Patients in the control group only received radiation without laughing therapy. The women in the test group differ significantly from the control group because they were older, suffered from diabetes more often and had larger breasts. All 3 of these factors are predictive for worse dermatitis.
medication and dosage study
The laughter therapy applied in this study consisted of a lecture on the advantages of laughter and group sessions, which included active movement, "which aims to create laughter, especially happy laugh and self -disrupted stimulated laugh". Each session lasted 60 minutes. The patients were observed by employees, and those "who did not laugh more than 10 times in every laughter therapy session were excluded from this study." (Speaking of pressure!) Patients who had "no fun with laughing therapy" were excluded from the study.
target parameter
A radiation oncology that was alleged for the subject assignment evaluated the degree of radiation matis. The patient's pain assessment within the radiation field was also assessed. The patients were examined at the beginning of radiation therapy up to 8 weeks after their conclusion at the beginning of their studies and at weekly intervals. At the beginning of the therapy and 1 week after completion, the serum level of the epidermal growth factor, the transforming growth factor beta and the fibroblast growth factor were measured in all patients.
important knowledge
three of the patients in the test group were excluded. Therefore, 15 patients ended the study in the test group and 19 in the control group, and their results were analyzed (table).
| degrees |
laugh group (n = 15) |
control group (n = 19) |
| 3 | 5 (33.3 %) | 7 (36.8 %) |
| 2 | 5 (33.3 %) | 9 (47.4 %) |
| 1 | 5 (33.3 %) | 2 (10.5 %) |
| 0 | 0 | 1 (5.3 %) |
In the test group, radiation matis of grade 3, 2 and 1 at 5 (33.3 %), 5 (33.3 %) or 5 patients (33.3 %) developed. In comparison, radiation matis of grade 3, 2, 1 and 0 at 7 (36.8 %), 9 (47.4 %), 2 (10.5 %) or 1 patient (5.3 %) developed in the control group. The test group showed a lower incidence of radiation matitis grade 2 or worse than the control group (33.3 % compared to 47.4 %). While the test group had a lower incidence of radiation matitis 2. Grade or worse than the control group (66.7 % vs. 84.2 %), these differences did not achieve statistical significance ( p = 0.053). The average maximum pain values in the test and control group were 2.53 and 3.95. The test group complained less about severe pain than the control group during radiation therapy; However, these differences were not statistically significant. Both in the univariate and multivariate analysis, the total dose of radiation therapy was significantly associated with the severity of radiation matis.
practice implications
While the results of this small pilot study indicate that tested laugh therapy reduced the risk of high -grade radiation matitis, these results did not achieve statistical significance, so the question is raised: "Why do we check this work?" As the authors emphasize: "The laughing therapy does not require a lot of time or money expenditure and the side effects of laughing therapy are very limited, so we suggest that laughing therapy can be carried out easily and inexpensively as supplementary therapy for breast patients can be carried out without confirming our favorable results." This is one of these "It will not hurt; it could help" situations in which the potential advantages outweigh the potential disadvantages.
This is one of these “It will not hurt; it could help situations in which the potential advantages outweigh the potential disadvantages.
Kimata has reported that laughter has a significant influence on a number of skin diseases, especially on atopic dermatitis. 1.2 in Kimatas Earlier studies served funny videos by Charlie Chaplin and Mr. Bean as a trigger. In this current process, laughter itself was brought about; The authors believe that the brain reacts equally to self -induced and externally stimulated laughter. This idea that every laugh has the same effect is still only an assumption.
laugh regulates the genes high, which control natural killer cells. 4 This increase in the activity of natural killer cells, which is associated with this high regulation, seems more like how much the test subjects enjoyed the film than with the intensity of the laughter that the look - i.e. Aspects ”. 5 - The question arises as to why the authors of the current radiation study excluded subjects to be inappropriately happy.
A study of January 2015 reported that laughing therapy with improvements in “factors such as general health ( p = 0.001), somatic symptoms ( p = 0.001), insomnia and anxiety.” 6 This was a randomized controlled study in which 72 senior citizens had taken part in participated in an old -age center. Half was inscribed in an experimental laugh group and the other half served as a control group. The data was collected based on a general health questionnaire. The test group took part in laughing therapy programs twice a week for 6 weeks.
It has not been clearly proven that laughter reduces radiation matitis, but since it has a clear benefit for general health, it still seems advisable to promote this therapy.
Only a few patients have simple access to the type of "laughter therapy sessions" that are used in these studies, but most, if not all, have access to online videos and films these days. The latter can be just as effective, if not more effective. In our practice, we encourage patients to take a look at something online for 30 minutes. We also encourage you to regularly deal with the more old -fashioned practice, to tell jokes. Our experience is that laughing therapy actually has side effects - that patients who actively use this therapy are apparently happier.
- Kimata H. Reduction of allergic reactions in atopic infants by laughing the mother. EUR J Clin Invest. 2004; 34 (9): 645-646.
- Kimata H. Lachen counteracts the increase in plasma neurotrophic stages and allergic wheal reactions to the skin due to cell phone-mediated stress. behavior med. 2004; 29 (4): 149-152.
- Mora-Ripoll R. The therapeutic value of laughter in medicine. aging Ther Health med. 2010; 16 (6): 56-64.
- Hayashi t, Tsujii s, iburi t, et al. Laughing regulates the genes that are related to the activity of the NK cells in diabetes. biomed. Res. 2007; 281-285.
- Takahashi K., Iwase M., Yamashita K., et al. The increase in the activity of natural killer cells by laughter in a crossover study. int. J. Mol. Med. 2001; 8 (6): 645-650.
- ghodsbin f, Sharif Ahmadi Z, Jahanbin I, Sharif F. The effects of laughing therapy on the general health of older people in relation to the Jaharene Community Center in Shiraz, Iran, 2014: A randomized controlled study. 2015; 3 (1): 31-38.